926 research outputs found
Receiver Architectures for MIMO-OFDM Based on a Combined VMP-SP Algorithm
Iterative information processing, either based on heuristics or analytical
frameworks, has been shown to be a very powerful tool for the design of
efficient, yet feasible, wireless receiver architectures. Within this context,
algorithms performing message-passing on a probabilistic graph, such as the
sum-product (SP) and variational message passing (VMP) algorithms, have become
increasingly popular.
In this contribution, we apply a combined VMP-SP message-passing technique to
the design of receivers for MIMO-ODFM systems. The message-passing equations of
the combined scheme can be obtained from the equations of the stationary points
of a constrained region-based free energy approximation. When applied to a
MIMO-OFDM probabilistic model, we obtain a generic receiver architecture
performing iterative channel weight and noise precision estimation,
equalization and data decoding. We show that this generic scheme can be
particularized to a variety of different receiver structures, ranging from
high-performance iterative structures to low complexity receivers. This allows
for a flexible design of the signal processing specially tailored for the
requirements of each specific application. The numerical assessment of our
solutions, based on Monte Carlo simulations, corroborates the high performance
of the proposed algorithms and their superiority to heuristic approaches
Apolipoprotein M mediates sphingosine-1-phosphate efflux from erythrocytes
Abstract Sphingosine-1-phosphate (S1P) is a bioactive lipid implicated in e.g. angiogenesis, lymphocyte trafficking, and endothelial barrier function. Erythrocytes are a main source of plasma S1P together with platelets and endothelial cells. Apolipoprotein M (apoM) in HDL carries 70% of plasma S1P, whereas 30% is carried by albumin. The current aim was to investigate the role of apoM in export of S1P from human erythrocytes. Erythrocytes exported S1P more efficiently to HDL than to albumin, particularly when apoM was present in HDL. In contrast, export of sphingosine to HDL was unaffected by the presence of apoM. The specific ability of apoM to promote export of S1P was independent of apoM being bound in HDL particles. Treatment with MK-571, an inhibitor of the ABCC1 transporter, effectively reduced export of S1P from human erythrocytes to apoM, whereas the export was unaffected by inhibitors of ABCB1 or ATPase. Thus, ABCC1 could be involved in export of S1P from erythrocytes to apoM
Dietary polyacetylenic oxylipins falcarinol and falcarindiol prevent inflammation and colorectal neoplastic transformation:A mechanistic and dose-response study in a rat model
Falcarinol (FaOH) and falcarindiol (FaDOH) are cytotoxic and anti-inflammatory polyacetylenic oxylipins, which are commonly found in the carrot family (Apiaceae). FaOH and FaDOH have previously demonstrated a chemopreventive effect on precursor lesions of colorectal cancer (CRC) in azoxymethane (AOM)-induced rats. The purpose of the present study was to elucidate possible mechanisms of action for the preventive effect of FaOH and FaDOH on colorectal precancerous lesions and to determine how this effect was dependent on dose. Gene expression studies performed by RT-qPCR of selected cancer biomarkers in tissue from biopsies of neoplastic tissue revealed that FaOH and FaDOH downregulated NF-κβ and its downstream inflammatory markers TNFα, IL-6, and COX-2. The dose-dependent anti-neoplastic effect of FaOH and FaDOH in AOM-induced rats was investigated in groups of 20 rats receiving a standard rat diet (SRD) supplemented with 0.16, 0.48, 1.4, 7 or 35 µg FaOH and FaDOH g−1 feed in the ratio 1:1 and 20 rats were controls receiving only SRD. Analysis of aberrant crypt foci (ACF) showed that the average number of small ACF (<7 crypts) and large ACF (>7 crypts) decreased with increasing dose of FaOH and FaDOH and that this inhibitory effect on early neoplastic formation of ACF was dose-dependent, which was also the case for the total number of macroscopic neoplasms. The CRC protective effects of apiaceous vegetables are mainly due to the inhibitory effect of FaOH and FaDOH on NF-κB and its downstream inflammatory markers, especially COX-2
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