29 research outputs found

    Characteristics of study sample at baseline (n = 1034).

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    <p>Baseline variables were choosen as predictor variables for multiple linear regression analysis (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031088#pone-0031088-t003" target="_blank">Table 3</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031088#pone-0031088-t004" target="_blank">Table 4</a>).</p><p>*(includes self reported angina pectoris or myocardial infarction or physician recorded coronary heart disease).</p

    Baseline and 5-year-follow-up values of MCS and PCS.

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    <p>Component scores of 5-year follow up were chosen as outcome variables of multiple linear regression analyses (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031088#pone-0031088-t003" target="_blank">Table 3</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031088#pone-0031088-t004" target="_blank">Table 4</a>).</p

    Results of the multiple linear regression analysis with several independent baseline variables predicting PCS at five years later.

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    <p>Coding of categorical variables is mentioned in the footnote.</p><p>*unstandardized regression coefficient; † standard error; ‡ standardized regression coefficient; statistically significant associations are printed in bold</p><p>Sex: male and female (referent); Nationality: German nationality (referent), other nationalities. Marital status: “married” (referent), “divorced/widowed” and “unmarried”. Duration of school education: ≤8, 9–10 (referent), 11–12, and > 2 years. Smoking status: variable ranging from 0 to 2, classified into “never”, “former” or “current”. Treatment with insulin: “yes” and “no” (referent). Diabetes-related complications: variable ranging from 0 (no complications) to 4 (four complications). Comorbid diseases: composite variable ranging from 0 to 4. Depression: “no” (referent) and “yes” (depression episode has been diagnosed).</p

    List of participating studies and number of Caucasian subjects included in at least one GxE analysis.

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    <p>List of participating studies and number of Caucasian subjects included in at least one GxE analysis.</p

    Main effects for the epidemiologic variables included in the analyses, derived from population-based studies only<sup>1</sup>.

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    <p>Main effects for the epidemiologic variables included in the analyses, derived from population-based studies only<sup><a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003284#nt104" target="_blank">1</a></sup>.</p

    Per-allele SNP odds ratios and 95% confidence intervals stratified by environmental risk factors of breast cancer, and combined SNP main effect.

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    <p>(A) <i>LSP1</i>-rs3817198 x Number of full-term births (among parous), (B) 1p11-rs11249433 x Parous (yes/no), (C) <i>CASP8</i>-rs17468277 x mean lifetime intake of alcohol (<20 g/day versus > = 20 g/day).</p

    Odds ratios of gene-environment interaction for risk of breast cancer with p-value<10<sup>−3</sup> by study.

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    <p>(A) <i>LSP1</i>-rs3817198 x Number of full-term births (among parous), (B) <i>LSP1</i>-rs3817198 x Number of full-term births (among parous), restricted to subjects not included in previous BCAC report, (C) 1p11-rs11249433 x Parous (yes/no), (D) <i>CASP8</i>-rs17468277 x mean lifetime intake of alcohol (<20 g/day versus > = 20 g/day).</p
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