Increased prevalence of metabolic syndrome in patients with bipolar disorder compared to a selected control group-a Northern Netherlands LifeLines population cohort study

OBJECTIVES: Metabolic syndrome (MetS) is highly prevalent among patients with bipolar disorder (BD). The aims of this cross-sectional study were to determine the prevalence of MetS in Dutch BD subjects and compare it with a control group, to examine the association of demographic and clinical characteristics with MetS in BD, and to determine the extent to which metabolic dysregulation is treated in those patients. METHODS: 493 Dutch adult patients (≥ 18 years) with BD receiving psychotropic drugs and 493 matched control subjects were compared using data from the biobank Lifelines. We determined MetS according to the National Cholesterol Education Program Adult Treatment Panel III-Adapted (NCEP ATP III-A) criteria. The difference in the prevalence of MetS and the associations with characteristics were analyzed with logistic regression. RESULTS: BD subjects (30.6%) showed a significantly higher prevalence of MetS compared to the control group (14.2%) (p < .001, OR:2.67, 95% CI:1.94-3.66). Univariate analysis showed that smoking, body mass index (BMI) and antidepressant drug use were associated with MetS. Multivariate analysis showed that smoking (OR:2.01) was independently associated with MetS in BD. For hypertension, hyperglycemia and lipid disorder pharmacological treatment was provided to respectively 69.5%, 24% and 18.4% of the BD subjects in our sample. LIMITATIONS: Duration of illness of BD subjects was unknown. CONCLUSIONS: This study demonstrated a higher prevalence of MetS in Dutch BD subjects compared to persons without BD. In addition, a remarkable undertreatment of some of the components of MetS was found

Medication

De veelal ongezonde leefstijl van mensen met een psychiatrische aandoening is onlosmakelijk verbonden met de medicatie die wordt voorgeschreven in de psychiatrie. In dit hoofdstuk gaan we dan ook uitgebreid in op het psychofarmacagebruik en beschrijven we de lichamelijke gevolgen van deze medicijnen. Daarnaast gaan we in op de achtergrond en de werkingsmechanismen van medicatie. Per medicatie- groep wordt uitgelegd hoe bijwerkingen kunnen ontstaan vanuit receptorniveau naar klinisch beeld. Lichamelijke screening wordt ingezet om verschillende lichamelijke klachten en risicofactoren systematischin kaart te brengen. Indien deze aanwezig zijn is het van belang dit te bespreken met de patiënt en samen een beleid vast te stellen. Pas alshet duidelijk is welke lichamelijke belemmeringen er zijn, kan een goed beleid worden gemaakt. De eerste stap is om te kijken welke medicijnen afgebouwd of omgezet kunnen worden om de bijwerkingen te vermin- deren. Daarna zou in samenspraak moeten worden bepaald welke niet- medicamenteuze opties er zijn om de bijwerkingen te doen afnemen. Indien dat ontoereikend is en/of de persoon voelt niets voor leefstijl- interventies, kan medicatie nodig zijn om de afwijkende waarden te behandelen, waarbij rekening moet worden gehouden met de bijwerkingen van die medicamenten. Leefstijladviezen vormen een rode draad dooralle fasen van de behandeling, en er kunnen ook specifieke leefstijl- psychiatrische interventies worden ingezet om de psychische klachten te verminderen. Dit kan weer leiden tot minder medicatiegebruik.Tot slot is het van belang dat de zorg dusdanig wordt georganiseerd dat er voldoende oog is voor zowel psychische als lichamelijke gezondheid

Everolimus and long acting octreotide as a volume reducing treatment of polycystic livers (ELATE): study protocol for a randomized controlled trial

Contains fulltext : 97893.pdf (publisher's version ) (Open Access)ABSTRACT: BACKGROUND: Polycystic liver disease (PLD) is defined as having more than 20 liver cysts and can present as a severe and disabling condition. Most symptoms are caused by the mass effect of the liver size and include abdominal pain and distension. The somatostatin analogues octreotide and lanreotide have proven to reduce polycystic liver volume. mTOR inhibitors such as everolimus inhibit cell proliferation and might thereby reduce growth of liver cysts. This trial aims to assess the benefit of combination therapy of everolimus and octreotide compared to octreotide monotherapy. In this study we present the structure of the trial and the characteristics of the included patients. METHODS/DESIGN: This is a randomized open-label clinical trial comparing the effect of 12 months of everolimus and octreotide to octreotide monotherapy in PLD patients. Primary outcome is change in liver volume determined by CT-volumetry. Secondary outcomes are changes in abdominal symptoms and quality of life. Moreover, safety and tolerability of the drugs will be assessed. DISCUSSION: This trial will compare the relative efficacy of combination therapy with octreotide and everolimus to octreotide monotherapy. Since they apply to different pathways of cystogenesis we expect that combining octreotide and everolimus will result in a cumulative reduction of polycystic liver volume. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov: NCT01157858

Rationale and design of the RESOLVE trial: lanreotide as a volume reducing treatment for polycystic livers in patients with autosomal dominant polycystic kidney disease

Contains fulltext : 109282.pdf (publisher's version ) (Open Access)BACKGROUND: A large proportion of patients with autosomal dominant polycystic kidney disease (ADPKD) suffers from polycystic liver disease. Symptoms arise when liver volume increases. The somatostatin analogue lanreotide has proven to reduce liver volume in patients with polycystic liver disease. However, this study also included patients with isolated polycystic liver disease (PCLD). The RESOLVE trial aims to assess the efficacy of lanreotide treatment in ADPKD patients with symptomatic polycystic livers. In this study we present the design of the RESOLVE trial. METHODS/DESIGN: This open-label clinical trial evaluates the effect of 6 months of lanreotide in ADPKD patients with symptomatic polycystic livers. Primary outcome is change in liver volume determined by computerised tomography-volumetry. Secondary outcomes are changes in total kidney volume, kidney intermediate volume and renal function. Furthermore, urinary (NGAL, alpha1-microglobulin, KIM-1, H-FABP, MCP-1) and serum (fibroblast growth factor 23) biomarkers associated with ADPKD disease severity are assessed to investigate whether these biomarkers predict treatment responses to lanreotide. Moreover, safety and tolerability of the drug in ADPKD patients will be assessed. DISCUSSION: We anticipate that lanreotide is an effective therapeutic option for ADPKD patients with symptomatic polycystic livers and that this trial aids in the identification of patient related factors that predict treatment response. TRIAL REGISTRATION NUMBER: Clinical trials.gov NCT01354405

Phenotype and treatment of polycystic liver disease. Where hepatology meets radiology

Contains fulltext : 117421.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 18 oktober 2013Promotor : Drenth, J.P.H

Fishing for new insights in epigenetics. The role of Polycomb group proteins during zebrafish development

Contains fulltext : 199771.pdf (publisher's version ) (Open Access)Radboud University, 9 januari 2019Promotor : Stunnenberg, H.G. Co-promotor : Kamminga, L.M.177 p