Crop Updates 2000 Cereals - part 4

This session covers twelve papers from different authors: BREEDING 1.Response to subsoil acidity of wheat genotypes differing in Al-tolerance, C. Tang, Z. Rengel, E. Diatloff and B. McGann, Soil Science and Plant Nutrition/CLIMA, University of Western Australia 2. Application of molecular markers in Barley Improvement, Mehmet Cakir1, Nick Galwey1 and David Poulsen2, 1Plant Sciences, Faculty of Agriculture, University of Western Australia, 2Queensland Department of Primary Industries, Hermitage Research Station, Queensland 3. Implementation of molecular markers for wheat improvement in the Western Region, M. Carter1, A. Briney1, R. Wilson2, R.H. Potter1 and M.G.K. Jones1, 1Western Australian State Agricultural Biotechnology Centre, Murdoch University, 2Crop Industries, Agriculture Western Australia 4. Performance in 1999 of recently released wheat varieties in Western Australia, Robin Wilson, Iain Barclay, Robyn McLean, Dean Diepeveen and Robert Loughman, Agriculture Western Australia ECONOMICS 5. Outlook for prices and implications for rotations, Ross Kingwell1 2, Michael O’Connell1, Simone Blennerhasset1 1Agriculture Western Australia, 2University of Western Australia 6. Price Risk Management and the Western Australian Grain Producer, Benjamin Michael Tiller, Muresk Institute of Agriculture FORECASTING 7. Can we forecast wheat yields in Western Australia, Senthold Asseng1, Holger Meinke2, and Bill Bowden3, 1CSIRO Plant Industry, 2 APSRU/DPI, 3Agriculture Western Australia ON FARM TESTING 8. On-farm testing, the quiet revolution continues, Jeff Russell1, Ivan Lee2 1Agriculture Western Australia, 2 Farmer Kunjin TopCrop group, Corrigin GRAIN STORAGE 9. CD-ROM tool for growers and advisers: Managing on-farm grain storage – effective practices for the delivery of quality assured products, Clare Johnson1, Chris Newman2 1Quality Wheat CRC Ltd, 2Production Resource Protection Services, Agriculture Western Australia 10. The Internet as a tool for managing grain insects, Robert Emery, Romolo Tassone and Ernestos Kostas, Agriculture Western Australia SUMMER CROPS AND WINDBREAK EFFECT ON YIELD 11. Summer crop Update and agronomic considerations, Graeme Ralph, Pioneer Hi-Bred Australia Pty Ltd 12. The effect of tree windbreaks on grain yield in the medium and low rainfall areas in Western Australia, Robert Sudmeyer, David Hall and Harvey Jones, Agriculture Western Australi

Discovery of novel GPVI receptor antagonists by structure-based repurposing.

Inappropriate platelet aggregation creates a cardiovascular risk that is largely managed with thienopyridines and aspirin. Although effective, these drugs carry risks of increased bleeding and drug 'resistance', underpinning a drive for new antiplatelet agents. To discover such drugs, one strategy is to identify a suitable druggable target and then find small molecules that modulate it. A good and unexploited target is the platelet collagen receptor, GPVI, which promotes thrombus formation. To identify inhibitors of GPVI that are safe and bioavailable, we docked a FDA-approved drug library into the GPVI collagen-binding site in silico. We now report that losartan and cinanserin inhibit GPVI-mediated platelet activation in a selective, competitive and dose-dependent manner. This mechanism of action likely underpins the cardioprotective effects of losartan that could not be ascribed to its antihypertensive effects. We have, therefore, identified small molecule inhibitors of GPVI-mediated platelet activation, and also demonstrated the utility of structure-based repurposing

Re-visiting Meltsner: Policy Advice Systems and the Multi-Dimensional Nature of Professional Policy Analysis

10.2139/ssrn.15462511-2

Modelling soil heterogeneity and wave scattering in geotechnical site response analysis

This study describes an approach for modeling wave scattering in geotechnical site response analysis by accounting for 2D spatial variability through correlated random fields. The results of 2D analyses with spatial variability are compared to those from 1D analyses with a deterministic homogeneous velocity profile and randomised profiles extracted from the 2D velocity model. Many ground motion indicators (including mean and standard deviation of various intensity measures) are investigated to assess and differentiate the influence from 1D velocity heterogeneities and 2D wave scattering, refraction, and surface wave generation. A detailed parametric analysis is conducted to determine how the various random field input parameters (such as the length scale, and strength of the heterogeneities) influence the predicted site response

Methods for Incorporating Soil Nonlinearity in Ground Motion Simulation

This poster discusses several possible approaches by which the nonlinear response of surficial soils can be explicitly modelled in physics-based ground motion simulations, focusing on the relative advantages and limitations of the various methodologies. These methods include fully-coupled 3D simulation models that directly allow soil nonlinearity in surficial soils, the domain reduction method for decomposing the physical domain into multiple subdomains for separate simulation, conventional site response analysis uncoupled from the simulations, and finally, the use of simple empirically based site amplification factors We provide the methodology for an ongoing study to explicitly incorporate soil nonlinearity into hybrid broadband simulations of the 2010-2011 Canterbury, New Zealand earthquakes

3D Seismic Site Response with Soil Heterogeneity and Wave Scattering

This poster discusses the on-going development of a 3D site response analysis framework that considers three important non-1D aspects of seismic site response: soil heterogeneity (spatial variability), bidirectional input ground motion, and multi-directional soil constitutive response. The focus is on the development and implementation of spatial variability explicitly modelled through correlated random fields, leading to seismic wave scattering. Importantly, the required site-specific inputs to apply the proposed approach in a practical setting are the same as those associated with conventional 1D site response analysis. This approach requires addressing several numerical and computational hurdles in order to enable 3D FE simulations with spatial variability to be computed and processed in a tractable manner. We present our theoretical and computational developments to date for an initial sensitivity study involving 960 2D model realizations (as a stepping stone to 3D), requiring extensive parallelization and high-performance computing resources. Insights on the scalability and parallelization of large dynamic OpenSEES models from this study are shared