Standardization and qualification of computer programs for circuit design

Study presents methods and initial procedures which may be obtained for development of more efficient uniform network analysis input language and theoretical tools to prove equivalence of data representations

Low frequency creep in CoNiFe films

The results of an investigation of domain wall motion excited by slow rise-time, bipolar, hard-axis pulses in vacuum deposited CoNiFe films 1500A to 2000A thick are presented. The results are consistent with those of comparable NiFe films in spite of large differences in film properties. The present low frequency creep data together with previously published results in this and other laboratories can be accounted for by a model which requires that the wall structure change usually associated with low frequency creep be predominately a gyromagnetic process. The correctness of this model is reinforced by the observation that the wall coercive force, the planar wall mobility, and the occurrence of an abrupt wall structure change are the only properties closely correlated to the creep displacement characteristics of a planar wall in low dispersion films

Pharmacokinetic Modeling of Intranasal Scopolamine in Plasma Saliva and Urine

An intranasal gel formulation of scopolamine (INSCOP) was developed for the treatment of Space Motion Sickness. The bioavailability and pharmacokinetics (PK) were evaluated under the Food and Drug Administration guidelines for clinical trials for an Investigative New Drug (IND). The aim of this project was to develop a PK model that can predict the relationship between plasma, saliva and urinary scopolamine concentrations using data collected from the IND clinical trial with INSCOP. METHODS: Twelve healthy human subjects were administered three dose levels (0.1, 0.2 and 0.4 mg) of INSCOP. Serial blood, saliva and urine samples were collected between 5 min to 24 h after dosing and scopolamine concentrations measured by using a validated LC-MS-MS assay. Pharmacokinetic Compartmental models, using actual dosing and sampling times, were built using Phoenix (version 1.2). Model discrimination was performed, by minimizing the Akaike Information Criteria (AIC), maximizing the coefficient of determination (r) and by comparison of the quality of fit plots. RESULTS: The best structural model to describe scopolamine disposition after INSCOP administration (minimal AIC =907.2) consisted of one compartment for plasma, saliva and urine respectively that were inter-connected with different rate constants. The estimated values of PK parameters were compiled in Table 1. The model fitting exercises revealed a nonlinear PK for scopolamine between plasma and saliva compartments for K21, Vmax and Km. CONCLUSION: PK model for INSCOP was developed and for the first time it satisfactorily predicted the PK of scopolamine in plasma, saliva and urine after INSCOP administration. Using non-linear PK yielded the best structural model to describe scopolamine disposition between plasma and saliva compartments, and inclusion of non-linear PK resulted in a significant improved model fitting. The model can be utilized to predict scopolamine plasma concentration using saliva and/or urine data that allows non-invasive assessment of pharmacotherapeutics of scopolamine in space and other remote environments without requiring blood sampling

The derived category of surface algebras: the case of the torus with one boundary component

In this paper we refine the main result of a previous paper of the author with Grimeland on derived invariants of surface algebras. We restrict to the case where the surface is a torus with one boundary component and give an easily computable derived invariant for such surface algebras. This result permits to give answers to open questions on gentle algebras: it provides examples of gentle algebras with the same AG-invariant (in the sense of Avella-Alaminos and Geiss) that are not derived equivalent and gives a partial positive answer to a conjecture due to Bobi\'nski and Malicki on gentle $2$-cycles algebras.Comment: 22 pages, a mistake concerning the computation of the mapping class group has been fixed, version 3: 25 pages, to appear in Algebras and Representation Theor

Exploring a rheonomic system

A simple and illustrative rheonomic system is explored in the Lagrangian formalism. The difference between Jacobi's integral and energy is highlighted. A sharp contrast with remarks found in the literature is pointed out. The non-conservative system possess a Lagrangian not explicitly dependent on time and consequently there is a Jacobi's integral. The Lagrange undetermined multiplier method is used as a complement to obtain a few interesting conclusion

Pharmacokinetic Modeling of Intranasal Scopolamine in Plasma Saliva and Urine

An intranasal gel dosage formulation of scopolamine (INSCOP) was developed for the treatment of Space Motion Sickness (SMS). The bioavailability and pharmacokinetics (PK) were evaluated under IND (Investigational New Drug) guidelines. The aim of the project was to develop a PK model that can predict the relationships among plasma, saliva and urinary scopolamine concentrations using data collected from the IND clinical trial protocol with INSCOP. Twelve healthy human subjects were administered at three dose levels (0.1, 0.2 and 0.4 mg) of INSCOP. Serial blood, saliva and urine samples were collected between 5 min to 24 h after dosing and scopolamine concentrations were measured by using a validated LCMSMS assay. PK compartmental models, using actual dosing and sampling time, were established using Phoenix (version 1.2). Model selection was based on a likelihood ratio test on the difference of criteria (2LL (i.e. log-likelihood ratio test)) and comparison of the quality of fit plots. The results: Predictable correlations among scopolamine concentrations in compartments of plasma, saliva and urine were established, and for the first time the model satisfactorily predicted the population and individual PK of INSCOP in plasma, saliva and urine. The model can be utilized to predict the INSCOP plasma concentration by saliva and urine data, and it will be useful for monitoring the PK of scopolamine in space and other remote environments using noninvasive sampling of saliva and/or urine

Charge Orbits of Extremal Black Holes in Five Dimensional Supergravity

We derive the U-duality charge orbits, as well as the related moduli spaces, of "large" and "small" extremal black holes in non-maximal ungauged Maxwell-Einstein supergravities with symmetric scalar manifolds in d=5 space-time dimensions. The stabilizer groups of the various classes of orbits are obtained by determining and solving suitable U-invariant sets of constraints, both in "bare" and "dressed" charges bases, with various methods. After a general treatment of attractors in real special geometry (also considering non-symmetric cases), the N=2 "magic" theories, as well as the N=2 Jordan symmetric sequence, are analyzed in detail. Finally, the half-maximal (N=4) matter-coupled supergravity is also studied in this context.Comment: 1+63 pages, 6 Table

A New Liquid Phase and Metal-Insulator Transition in Si MOSFETs

We argue that there is a new liquid phase in the two-dimensional electron system in Si MOSFETs at low enough electron densities. The recently observed metal-insulator transition results as a crossover from the percolation transition of the liquid phase through the disorder landscape in the system below the liquid-gas critical temperature. The consequences of our theory are discussed for variety of physical properties relevant to the recent experiments.Comment: 12 pages of RevTeX with 3 postscript figure

Twisted and Nontwisted Bifurcations Induced by Diffusion

We discuss a diffusively perturbed predator-prey system. Freedman and Wolkowicz showed that the corresponding ODE can have a periodic solution that bifurcates from a homoclinic loop. When the diffusion coefficients are large, this solution represents a stable, spatially homogeneous time-periodic solution of the PDE. We show that when the diffusion coefficients become small, the spatially homogeneous periodic solution becomes unstable and bifurcates into spatially nonhomogeneous periodic solutions. The nature of the bifurcation is determined by the twistedness of an equilibrium/homoclinic bifurcation that occurs as the diffusion coefficients decrease. In the nontwisted case two spatially nonhomogeneous simple periodic solutions of equal period are generated, while in the twisted case a unique spatially nonhomogeneous double periodic solution is generated through period-doubling. Key Words: Reaction-diffusion equations; predator-prey systems; homoclinic bifurcations; periodic solutions.Comment: 42 pages in a tar.gz file. Use ``latex2e twisted.tex'' on the tex files. Hard copy of figures available on request from [email protected]