Surgery for intra-abdominal hydatid disease: a single centre experience

Background: Hydatid cyst is one of the commonly encountered parasitic disease in agricultural countries. Man is an accidental host. However the parasite can cause cystic lesions in various organ systems of the body. Intra-abdominal hydatid cyst continues to be a challenging problem.Methods: Case records of patients diagnosed and surgically treated for intra-abdominal hydatid disease were studied. Demographic details, diagnostic modalities and surgical approach to each patient was studied.Results: Ten cases of intra-abdominal hydatid disease diagnosed and managed in a single surgical centre were studied.  Eight patients had hepatic disease, one had splenic disease and one had disseminated disease which included both hepatic and peritoneal disease. All were treated surgically.Conclusions: Males involved in livestock industry are commonly affected. Liver is the commonest intra-abdominal site for hydatid disease. CT scan is diagnostic. Open surgery still continues to be the safest option for treating this condition

Kikuchi Fujimoto lymphadenitis- an uncommon entity in the surgical outpatients: a case report

Kikuchi Fujimoto lymphadenitis is a benign self-limiting disease with subacute necrotizing lymphadenopathy of unknown cause. The clinical, histopathological and immunohistochemical features point to viral etiology hence delaying diagnosis commonly. Clinicians and pathologists awareness of this disorder may prevent misdiagnosis and inappropriate treatment. We describe here a case of a young woman admitted under our care with fever and cervical lymphadenopathy. Cervical lymph node biopsy revealed the rare clinical disorder of Kikuchi Fujimoto lymphadenitis which is not thought of as a primary cause of lymphadenopathy in the Indian subcontinent where tuberculosis is widely prevalent

Neurofibroma presenting as clitoromegaly

Congenital clitoromegaly is common, but acquired clitoromegaly due to neurofibroma is rare. Here we present a case report of Neurofibroma presenting as clitoromegaly. A 7 year female had history of painless clitoromegaly since 3 years. Her hormonal assays and radiological examination of abdomen and pelvis did not reveal any abnormality. She was subjected to clitoroplasty for correction of clitoromegaly

Suture less 3D mesh repair of sliding inguinal hernia: a case report

Sliding hernias involving the urinary bladder are rare, almost exclusively seen in men. As a result of slipping of the posterior parietal peritoneum on the underlying retroperitoneal structures, the posterior wall of the sac is not formed of the peritoneum alone, but by a portion of the bladder on either side. This case report presents the case of a 54 year old male patient with  Right groin swelling since two years, gradually increasing in size with complaints of  pain at the site of the swelling prior to voiding and also, an increase in the size of the swelling on retaining urine for a long duration. Based on clinical and radiological findings patient was diagnosed with Sliding inguinal hernia with bladder component, and underwent Open suture less 3D Mesh repair, with replacement of the bladder in the retroperitoneal space. The aim of this case report is to highlight the successful surgical management of a rare sliding hernia involving the urinary bladder using suture less 3D mesh repair

Variation in cytokine genes can contribute to severity of acetabular osteolysis and risk for revision in patients with ABG 1 total hip arthroplasty: a genetic association study

<p>Abstract</p> <p>Background</p> <p>The differences in total hip arthroplasty (THA) survivorship may be influenced by individual susceptibility to periprosthetic osteolysis. This may be driven by functional polymorphisms in the genes for cytokines and cytokine receptors involved in the development of osteolysis in THA, thereby having an effect on the individual's phenotype.</p> <p>Methods</p> <p>We performed a study on 22 single-nucleotide polymorphisms (SNPs) for 11 cytokines and two cytokine receptor candidate genes for association with severity of acetabular osteolysis and risk to failure in THA. Samples from 205 unrelated Caucasian patients with cementless type THA (ABG 1) were investigated. Distribution of investigated SNP variants between the groups of mild and severe acetabular osteolysis was determined by univariate and multivariate analysis. Time-dependent output variables were analyzed by the Cox hazards model.</p> <p>Results</p> <p>Univariate analysis showed: 1) <it>TNF</it>-238*A allele was associated with severe osteolysis (odds ratio, OR = 6.59, <it>p </it>= 0.005, population attributable risk, PAR 5.2%); 2) carriers of the <it>IL6</it>-174*G allele were 2.5 times more prone to develop severe osteolysis than non-carriers (OR = 2.51, <it>p </it>= 0.007, PAR = 31.5%); 3) the carriage of <it>IL2</it>-330*G allele was associated with protection from severe osteolysis (OR = 0.55, <it>p </it>= 0.043). Based on logistic regression, the alleles <it>TNF</it>-238*A and <it>IL6</it>-174*G were independent predictors for the development of severe acetabular osteolysis. Carriers of <it>TNF</it>-238*A had increased cumulative hazard of THA failure according to Cox model (<it>p </it>= 0.024). In contrast, <it>IL2</it>-330*G allele predicted lower cumulative hazard of THA failure (<it>p </it>= 0.019).</p> <p>Conclusion</p> <p>Genetic variants of proinflammatory cytokines TNF-alpha and IL-6 confer susceptibility to severe OL. In this way, presence of the minor <it>TNF </it>allele could increase the cumulative risk of THA failure. Conversely, SNP in the <it>IL2 </it>gene may protect carriers from the above THA complications.</p