Synthesis, Characterization and Pharmacological evaluation of some newer Benzothiazole derivatives

The objective of the present work is to develop safer new chemical entities that show good anticonvulsant effects and antimicrobial actions. The current work describes the synthesis of Benzothiazole derivatives with encouraging anticonvulsant activity against MES and scPTZ tests with interesting pattern of antimicrobial effects. The synthesized Benzothiazole derivatives could be considered as lead molecule for the development of therapeutic agents. Many polycyclic and fused ring systems containing the thiazolenucleus(I) are well known. The most important is bicyclic system wherein the second ring benzene is fused to the 4,5 position of thiazole ring i.e. Benzothiazole.(II

Health management design considerations for an all electric aircraft

This paper explains the On-board IVHM system for a State-Of-the-Art “All electric aircraft” and explores implementing practices for analysis based design, illustrations and development of IVHM capabilities. On implementing the system as an on board system will carry out fault detection and isolation, recommend maintenance action, provides prognostic capabilities to highest possible problems before these became critical. The vehicle Condition Based Maintenance (CBM) and adaptive control algorithm development based on an open architecture system which allow “Plug in and Plug off” various systems in a more efficient and flexible way. The scope of the IVHM design included consideration of data collection and communication from the continuous monitoring of aircraft systems, observation of current system states, and processing of this data to support proper maintenance and repair actions. Legacy commercial platforms and HM applications for various subsystems of these aircraft were identified. The list of possible applications was down-selected to a reduced number that offer the highest value using a QFD matrix based on the cost benefit analysis. Requirements, designs and system architectures were developed for these applications. The application areas considered included engine, tires and brakes, pneumatics and air conditioning, generator, and structures. IVHM design program included identification of application sensors, functions and interfaces; IVHM system architecture, descriptions of certification requirements and approaches; the results of a cost/benefit analyses and recommended standards and technology gaps. The work concluded with observations on nature of HM, the technologies, and the approaches and challenges to its integration into the current avionics, support system and business infrastructure. The IVHM design for All Electric Hybrid Wing Body (HWB) Aircraft has a challenging task of addressing and resolving the shortfalls in the legacy IVHM framework. The challenges like sensor battery maintenance, handling big data from SHM, On-Ground Data transfer by light, Extraction of required features at sensor nodes/RDCUs, ECAM/EICAS Interfaces, issues of certification of wireless SHM network has been addressed in this paper. Automatic Deployable Flight Data recorders are used in the design of HWB aircraft in which critical flight parameters are recorded. The component selection of IVHM system including software and hardware have been based on the COTS technology. The design emphasis on high levels of reliability and maintainability. The above systems are employed using IMA and integrated on AFDX data bus. The design activities has to pass through design reviews on systematic basis and the overall approach has been to make system highly lighter, effective “All weather” compatible and modular. It is concluded from the study of advancement in IVHM capabilities and new service offerings that IVHM technology is emerging as well as challenging. With the inclusion of adaptive control, vehicle condition based maintenance and pilot fatigue monitoring, IVHM evolved as a more proactively involved on-board system

Bio-molecular applications of recent developments in optical tweezers

In the past three decades, the ability to optically manipulate biomolecules has spurred a new era of medical and biophysical research. Optical tweezers (OT) have enabled experimenters to trap, sort, and probe cells, as well as discern the structural dynamics of proteins and nucleic acids at single molecule level. The steady improvement in OT\u2019s resolving power has progressively pushed the envelope of their applications; there are, however, some inherent limitations that are prompting researchers to look for alternatives to the conventional techniques. To begin with, OT are restricted by their one-dimensional approach, which makes it difficult to conjure an exhaustive three-dimensional picture of biological systems. The high-intensity trapping laser can damage biological samples, a fact that restricts the feasibility of in vivo applications. Finally, direct manipulation of biological matter at nanometer scale remains a significant challenge for conventional OT. A significant amount of literature has been dedicated in the last 10 years to address the aforementioned shortcomings. Innovations in laser technology and advances in various other spheres of applied physics have been capitalized upon to evolve the next generation OT systems. In this review, we elucidate a few of these developments, with particular focus on their biological applications. The manipulation of nanoscopic objects has been achieved by means of plasmonic optical tweezers (POT), which utilize localized surface plasmons to generate optical traps with enhanced trapping potential, and photonic crystal optical tweezers (PhC OT), which attain the same goal by employing different photonic crystal geometries. Femtosecond optical tweezers (fs OT), constructed by replacing the continuous wave (cw) laser source with a femtosecond laser, promise to greatly reduce the damage to living samples. Finally, one way to transcend the one-dimensional nature of the data gained by OT is to couple them to the other large family of single molecule tools, i.e., fluorescence-based imaging techniques. We discuss the distinct advantages of the aforementioned techniques as well as the alternative experimental perspective they provide in comparison to conventional OT

Power consumption management system (PCMS) in wired networks using adaptive genetic algorithm

Power consumption in both wired and wireless networks is becoming an increasingly important concern across the world. Most scholars have concentrated on wireless, so we have taken wired networks as our focus. Wired network operators had an increased network concern to meet the decrease in traffic levels from which service quality (QoS) is achieved and maximize power consumption. To achieve the QOS and power consumption in a wired network, we provided comprehensive Power Consumption Management (PCMS) research modules that provide current and future access networks. The results of PCMS are being tested out with the genetic algorithm gives us the best-optimized module

Use of emergency contraceptive pill in India: boon or bane

It has been almost fifteen years since emergency contraceptive pills (ECPs) have been made available over the counter in India. There have been concerns about the overuse/misuse of ECPs and probability to replace regular contraceptive methods. This article presents various facets of the use of emergency contraceptive pills in India and highlights the importance of potential research to prevent its misuse

Evaluation and correlation for growth, yield and quality traits of ridge gourd (Luffa acutangula) under arid conditions

Landraces of ridge gourd [Luffa acutangula (Roxb.) L.] are spread over a wide range of environments in India and their fruits are consumed as vegetable. The dry fruits of six commonly grown genotypes were collected from different parts of Rajasthan. The collected materials were evaluated during summer season of 2011 and 2012 under hot arid conditions of western Rajasthan for growth traits, flowering, yield, yield components and quality traits. The evaluated genotypes showed significant variation for most of these traits, except pH of flesh. Average number of fruits per plant was the highest in AHRG 29 (21.75) and the lowest in AHRG 27 (17.30), which had the highest fruit length (27.26cm), fruit diameter (5.13cm), ovary length (8.06 cm) and fibre content (1.96 g/100g edible portion). The highest fruit hardness was also recorded in AHRG 27 (4.91 kg/cm2), whereas the lowest in AHRG 29 (3.54 kg/cm2). Significant correlation coefficients among growth, flowering, yield, yield traits and quality traits were found. The marketable yield/plant had positive and highly significant correlation with fruit weight (0.834) and number of marketable fruit/plant (0.624) at phenotypic level. The results of this study could be used in breeding programs for improving local landraces of ridge gourd grown in Rajasthan, India

Productivity, competition behaviour and weed dynamics of various row proportions of maize (Zea mays)-legumes intercropping in Arunachal Pradesh

Intercropping is the simultaneous cultivation of more than one crop species on the same piece of land and is regulated as the practical application of basic ecological principles such as diversity, competition and facilitation. Farmers of the region sow many crops in a piece of land, without following any row proportion geometrics and hence crop productivity is considerably low. A research was carried out to assess the feasibility of raising intercrops in association with maize (Zea mays L.) at ICAR Research Complex for NEH Region, Basar during 2010 and 2011. The results indicated that biomass accumulation was the highest with 1:1 than in the 1:5 row proportions. Leaf area index of maize with intercrop was the highest with 1:5 row proportions. The maize grain yield was obtained relatively higher with solitary maize followed by 1:2 of maize-soybean [Glycine max (L.) Merr.]. Maize equivalent yield was 55.5% higher with 1:5 of maize-groundnut (Arachis hypogaea L.) over the solitary maize, consequently, production efficiency was remarkably improved by 48.9% with 1:5 of maize-groundnut. Land equivalent ratio, area time equivalent ratio and monetory advantage index were favourable for the intercropping implying their intrinsic advantage over solitary planting. Weed density and dry biomass were lower with 1:5 row proportions which resulted in higher weed smothering efficiency

Doubled Haploid Technology in Maize (Zea mays): Status and Applications

Not AvailableMaize is the third most important staple crop after rice and wheat with enormous diversity and adaptation ability. Hybrid breeding is the most important approach for developing high yielding cultivars in maize. It relies upon the generation of pure inbred lines with desirable traits in quick span to achieve higher genetic gains. The rapidly rising global population and climate change necessitates the development of innovative technologies that can help to safeguard the food security in future. Doubled Haploid (DH) technology is the best approach for rapid development of new inbred lines. DH technology has contributed immensely in the rapid generation of inbred lines and hybrid development. In addition, the use of molecular markers with DH technology resulted into mapping of genomic regions for different traits. The recent development in identification of alternative markers for haploid selection and genome editing approaches will further strengthen the DH technology for commercial maize breeding. This review describes important landmarks of maize DH technology, its applications, and recent advances in utilization of emerging technologies, viz. CRIPSR-cas and genomics approaches for DH technology.Not Availabl