Interest of high shear wet granulation to produce drug loaded porous calcium phosphate pellets for bone filling

International audienceSpherical porous calcium phosphate pellets were fabricated by high shear wet granulation using native starch as a binder. After a heat treatment to eliminate the organic template, pellets were loaded with ibuprofen by solvent evaporation method. In vitro drug release kinetics was determined using an USP II apparatus (Prolabo Dissolution Tester, France). Results showed the interest of the calcination and of the increase in the binder-porogen content, to improve the drug loading (higher drug content) and prolong the release of the drug substance

Elaboration of a well-ordered porous bioceramic via a heterocoagulation colloidal process

International audienceThe purpose of this study was to develop bioceramics with a well-defined porous structure in order to control drug loading and release over time. Porous structures were obtained through colloidal processing, using polymethyl methacrylate (PMMA) microspheres as templates (core) and hydroxyapatite (HA) nanoparticles as inorganic building blocks (shell). Dispersed HA suspensions were prepared and their electrokinetic properties were studied to determine a dispersant giving a high positive zeta potential (opposite to the negative zeta potential of PMMA). Upon mixture of well-dispersed HA and PMMA suspensions of opposite charge, coreshell structures were formed via heterocoagulation. After consolidation, polymers were removed by calcination, resulting in a porous structure of controlled size and distribution

Nuclear magnetic resonance study of anion and cation dynamics in CsSiH3

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