Metalloporphyrins as chemical mimics of cytochrome P-450 systems

Abstract: Certain synthetic metalloporphyrins have been shown to mimic the in vivo metabolism of some pharmaceuticals. Oxidation, hydroxylation and N-demethylation yielded synthetic metabolites. If found to be general, this lays the foundation of a predictive basis to optimize analog design of inhibitors with reduced oxidative reactivity, to determine the proclivity of drugs to form biologically active metabolites and provides a convenient methodology for their preparation

La Química médica en el desarrollo de las Sociedades. Biodiversidad y Productos naturales

This document has been prepared by the IUPAC Medicinal Chemistry section and is backed by a large number of scientists, many of whom have had direct involve-ment and whose names appear at the end of the article. This work discusses the role that the discovery of new medicinal agents has in the development of societies as well as in the conservation of biodiversity in terms of the work carried out on natural products. Also included are several recommendations for countries which are presently in search of their own scientific and technological development in medicinal agents. The IUPAC Medicinal Chemistry section would appreciate the collaboration of the scientific societies in every country to aid in the diffusion of this document.Se presenta un documento de opinión elaborado por la sección de Medicinal Chemistry de IUPAC, que cuenta además con el acuerdo de un buen número de científi-cos, algunos de los cuales figuran al final del trabajo. Se plantea el papel que puede tener el descubrimiento de medicamentos en el desarrollo de las sociedades y mantenimiento de la biodiversidad en base a los trabajos en productos naturales. Se plantean recomendaciones de aplicación en los países que están en la bús-queda de su desarrollo científico y tecnológico en el medicamento. Es intención de la sección de Medicinal Chemistry de IUPAC su difusión inter-nacional, por lo que agradecen la colaboración de las sociedades científicas de los dife-rentes países