Case Report - Darier's disease following radiotherapy for carcinoma of cervix

Darier-White disease is due to a defect in the ATP2A2 gene encoding the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA2b). We report a case of carcinoma cervix in whom Darier\u2032s disease manifested after the initiation of radiation therapy. Conventional cytogenetics on peripheral blood revealed non-clonal constitutional autosomal and X chromosome abnormalities suggesting radiation induced gene toxicity. Occurrence of Darier\u2032s disease in our case could be due to treatment induced sustained differentiation in the Darier\u2032s affected skin by an unknown mechanism. Late onset or sporadic Darier\u2032s disease is the other possibility