原子層物質における非平衡量子現象とトポロジカル超伝導

京都大学新制・課程博士博士(理学)甲第22988号理博第4665号新制||理||1669(附属図書館)京都大学大学院理学研究科物理学・宇宙物理学専攻(主査)教授 柳瀬 陽一, 教授 田中 耕一郎, 教授 石田 憲二学位規則第4条第1項該当Doctor of ScienceKyoto UniversityDFA

Two-qubit gate using conditional driving for highly detuned Kerr-nonlinear parametric oscillators

A Kerr-nonlinear parametric oscillator (KPO) is one of the promising devices to realize qubits for universal quantum computing. The KPO can stabilize two coherent states with opposite phases, yielding a quantum superposition called a Schr\"{o}dinger cat state. Universal quantum computing with KPOs requires three kinds of quantum gates: $R_z, R_x$, and $R_{zz}$ gates. We theoretically propose a two-qubit gate $R_{zz}$ for highly detuned KPOs. In the proposed scheme, we add another two-photon drive for the first KPO. This leads to the $R_{zz}$ gate based on the driving of the second KPO depending on the first-KPO state, which we call "conditional driving." First, we perform simulations using a conventional KPO Hamiltonian derived from a superconducting-circuit model under some approximations and evaluate the gate fidelity. Next, we also perform numerical simulations of the two-qubit gate using the superconducting-circuit model without the approximations. The simulation results indicate that two-qubit gates can be implemented with high fidelity ($>99.9\%$) for rotation angles required for universality.Comment: 9 pages, 7 figure

FACILE AND SENSITIVE HPLC-UV METHOD FOR DETERMINATION OF NINTEDANIB IN RAT PLASMA

Objective: In this study, a facile and sensitive high-performance liquid chromatographic method for determination of nintedanib in rat plasma was developed and validated.Methods: After plasma protein was precipitated by addition of acetonitrile, the supernatant underwent centrifugation. An aliquot was then injected into a high-performance liquid chromatographic system with a Mightysil RP-18 GP II ODS column (250 × 3.0 mm, length by inner diameter, 5-μm particle size) maintained at 50 °C. A mobile phase mixture of 20 mmol phosphate buffer (pH 3.0) and acetonitrile (7:3, v/v) was used at a flow rate of 0.6 mL/min, with UV detection at a wavelength of 390 nm for isocratic separation and detection of nintedanib, its main metabolite (BIBF1202), and p-nitrophenol as an internal standard.Results: The quantitative range of nintedanib concentration in this method was 12.5–400 ng/ml, and the calibration curves were linear. The intra-and inter-day accuracy values (relative errors) were in the range of −3.65%–4.00% and −3.65%–3.64%, respectively. The intra-and inter-day precision values (relative standard deviations) were<5.9% and 8.36%, respectively. The method was successfully applied to a pharmacokinetic analysis of nintedanib in rats after intravenous administration.Conclusion: In this study, a rapid, sensitive, and simple HPLC-UV method for the quantitation of nintedanib in rat plasma was developed and validated. The method was shown to be accurate and precise and was successfully applied to a pharmacokinetic study

Clinical and Parasitological Effects of Aspilia africana (Pers.) C.D. Adams in Fifteen Patients with Uncomplicated Malaria

This paper reports the findings of a clinical study of a herbal preparation of Aspilia africana (Pers.) C.D. Adams against malaria, corroborated by in vitro antiplasmodial and cytotoxicity tests. In a non-controlled prospective design, 15 patients with uncomplicated malaria were administered with the herbal preparation and assessed for clinical manifestations of malaria, parasitaemia and global quality of life using the Kanorfsky Performance Scale. Antiplasmodial activity of extracts against the chloroquine-resistant strain of Plasmodium falciparum Dd2 was determined using the [3H]-hypoxanthine radioactive method while cytotoxicity against human urinary bladder carcinoma (ECV-304) and human hepatocellular carcinoma (HepG2) cell lines was determined using the MTT assay. Remarkable clinical improvements occurred 3 to 21 days after initiation of treatment. Forty nine days after starting treatment, all 15 patients had complete resolution of malaria symptoms and were cleared of parasitaemia and attained a Karnofsky Performance score of 100. The petroleum ether/ethyl acetate extract possessed in vitro antiplasmodial activity (IC50 30μg/ml) but no remarkable cytotoxicity. The A. africana preparation shows potential as an alternative for the management of uncomplicated malaria.East and Central African Journal of Pharmaceutical Sciences Vol. 12 (2009) 37-4

Ab initio calculation for electronic structure and optical property of tungsten carbide in a TiCN-based cermet for solar thermal applications

We present an ab initio calculation to understand electronic structures and optical properties of a tungsten carbide WC being a major component of a TiCN-based cermet. We found that the WC has a fairly low-energy plasma excitation $\sim$0.6 eV (2 $\mu$m) and therefore can be a good constituent of a solar selective absorber. The evaluated figure of merit for photothermal conversion is prominently high compared to those of the other materials included in the TiCN-based cermet. The imaginary part of the dielectric function is considerably small around the zero point of the real part of the dielectric function, corresponding to the plasma excitation energy. Therefore, a clear plasma edge appeared, ensuring the high performance of the WC as the solar absorber.Comment: 13pages, 8 figures, 2table

エイゴ カツドウ ニオケル ジブン ノ チ オ ツクリダス コドモ

英語活動におけるコミュニケーションにおいて，子どもたちは自分の表現でも通じるといったある程度の自信をもっている。しかし，伝えたいことがあっても，表現することが困難であると，やりとりをやめてしまうことがある。どうすれば相手にうまく伝わるのか，どうすれば相手の伝えたいことをうまく受け取ることができるのか，伝え方や聞き方を試行錯誤しながら，コミュニケーションを図ろうとする。その際，教師の会話をモデルとしたり，友達の表現のよさを真似たり，コミュニケーションのおもしろさや楽しさに気付き，伝え合うよさを実感したり体得したりして，自分なりに取り込んでいくようになることが肝要である。こうして，創り出したものや，活動のよさを意味付けしてとらえたものを自分の「知」とする。この，自分の「知」を創り出す子どもを育てるための支援について実践報告する

Improvement in automated quantitation of myocardial perfusion abnormality by using iterative reconstruction image in combination with resolution recovery, attenuation and scatter corrections for the detection of coronary artery disease

13301甲第4801号博士（保健学）金沢大学博士論文本文Full 以下に掲載：Annals of Nuclear Medicine 31(2) pp.181-189 2017. Springer. 共著者：Taiki Chono, Masahisa Onoguchi, Takayuki Shibutani, Akiyoshi Hashimoto, Tomoaki Nakata, Naoya Yama, Kazufumi Tsuchihashi, Masamitsu Hatakenak