Genetic analysis of muscle development in Drosophila melanogaster

The different thoracic muscles of Drosophila are affected specifically in the mutants: stripe (sr), erect wing (ewg), vertical wings (vtw), and nonjumper (nj). We have tested the extent of this specificity by means of a genetic analysis of these loci, multiple mutant combinations, and gene dosage experiments. A quantitative, rather than a qualitative, specificity is found in the mutant phenotypes. All muscles are altered by mutations in any given gene, but the severity of these alterations is muscle specific. The locus stripe seems to have a polar organization where different allelic combinations show quantitative specificity in the muscle affected. In addition to the muscle phenotypes, neural alterations are detected in these mutants. The synergism found between ewg, vtw and ewg, sr as well as the dosage effect of the distal end of the X chromosome upon the expression of ewg and sr suggests the existence of functional relationships among the loci analyzed.Peer Reviewe

Advanced CO2 Capture Process Using MEA Scrubbing: Configuration of a Split Flow and Phase Separation Heat Exchanger

AbstractCO2 capture process using aqueous Monoethanolamine (MEA) scrubbing is a well-proven and commercially-ready technology for reducing CO2 emission to the atmosphere. Although the MEA scrubbing is the one of the most suitable technologies for post-combustion CO2 capture, the MEA process has a critical problem which is high consumption of reboiler heat energy for solvent regeneration. In order to reduce the reboiler heat requirement, this paper suggests an advanced configuration of MEA process which consists of split flow and a phase separation heat exchanger. The split flow permits to reduce the reflux ratio in the stripper and the phase separation heat exchanger permits to alleviate preheating duty loss. As a result, the regeneration energy of the advanced process is reduced by 2.84GJ/ton CO2, which is lower than one of the reference process by 27%.CO2 capture; post combustion CO2 capture; advanced stripper configuration; cold solvent split; rich vapor compressio

Interactive plant simulation modeling for developing an operator training system in a natural gas pressure-regulating station

Abstract This study proposes a method of interactive plant simulation modeling which delivers the online simulated results to the field operators and induces them to take proper actions in the case of pre-identified accident scenarios in a chemical plant. The developed model integrates the real-time process dynamic simulation with 3D-CFD accident simulation in a designed interface using object linking and embedding technology so that it can convey to trainees the online information of the accident which is not available in existing operator training systems. The model encompasses the whole process of data transfer till the end of the training at which a trainee operates an emergency shutdown system in a programmed model. In this work, an overall scenario is simulated which is from an abnormal increase in the main valve discharge (second) pressure due to valve malfunction to accidental gas release through the crack of a pressure recorder, and the magnitude of the accident with respect to the lead time of each trainees emergency response is analyzed. The model can improve the effectiveness of the operator training system through interactively linking the trainee actions with the simulation model resulting in different accident scenarios with respect to each trainees competence when facing an accident.This research was supported by a Grant No. (14IFIP-B085984-03) from Smart Civil Infrastructure Research Program funded by the Korea Government Ministry of Land, Infrastructure and Transport (MOLIT) and The Korea Agency for Infrastructure Technology Advancement(KAIA), and by Korea Ministry of Environment (MOE) as the Chemical Accident Prevention Technology Development Project (No. 2015001950003)

Human-aided, computer-based design paradigm : the automation of conceptual process design

Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1994.Includes bibliographical references (leaves 183-189).by Chonghun Han.Sc.D