Cooperative nucleation leading to ripple formation in InGaAs/GaAs films

In0.25Ga0.75AsIn0.25Ga0.75As epilayers were grown on GaAs (001) substrates (1.8% misfit strain) by molecular beam epitaxy to investigate the two-dimensional to three-dimensional transition as a function of thickness (t ⩽ 30 MLs).(t⩽30MLs). Tapping-mode atomic force micrographs show the evolution of the morphology as a function of thickness. As the film is deposited, the nucleation of 3D islands followed by cooperative nucleation of pits is observed. As the thickness increases, both islands and pits continue to nucleate and grow until they coalesce, resulting in a fully formed ripple morphology running along the [10].[11̄0]. The ripples also exhibit a secondary alignment roughly along the 〈310〉 which is attributed to the nucleation of islands with {136} faces. © 2000 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/70708/2/APPLAB-76-17-2382-1.pd

Spins of the supermassive black hole in M87: new constraints from TeV observations

The rapid TeV $\gamma-$ray variability detected in the well-known nearby radio galaxy M87 implies an extremely compact emission region (5-10 Schwarzschild radii) near the horizon of the supermassive black hole in the galactic center. TeV photons are affected by dilution due to interaction with the radiation field of the advection-dominated accretion flow (ADAF) around the black hole, and can thus be used to probe the innermost regions around the black hole. We calculate the optical depth of the ADAF radiation field to the TeV photons and find it strongly depends on the spin of the black hole. We find that transparent radii of 10 TeV photons are of $5R_{\rm S}$ and $13R_{\rm S}$ for the maximally rotating and non-rotating black holes, respectively. With the observations, the calculated transparent radii strongly suggest the black hole is spinning fast in the galaxy. TeV photons could be used as a powerful diagnostic for estimating black hole spins in galaxies in the future.Comment: 4 pages, 4 figures. to appear in ApJ

Addressing the interplay between apoptosis and glucose metabolism in liver cirrhosis and hcc

Introduction: Pro-inflammatory signalling in the liver promotes the appearance of a metabolic phenotype that involves the transition from mitochondrial respiration to aerobic glycolysis. It was demonstrated that this metabolic shift occurs during the transition from healthy and early stage of liver injury (NAFLD/NASH, ALD to late stage of disease (i.e. cirrhosis), and further escalates during HCC development.1,2This metabolic signature enables dividing cells to satisfy anabolic and energetic needs for biomass production and to suppress apoptotic signalling, which is consistent with increased compensatory hepatic cell proliferation typical of cirrhotic and HCC livers. However other studies in contrast have suggested that hepatocytes are unable to sustain glycolysis during late stage of chronic liver disease.3 Method: We used unbiased gene expression analyses of microarray datasets to investigate the expression of glycolytic genes in cirrhotic and HCC livers and correlated their expression with patient outcome. Furthermore, by using a combination of in vitro and in vivo analyses we have characterised the abilities of a novel anti-apoptotic gene to regulate aerobic glycolysis in liver cirrhosis and HCC. Results: mRNA profiling showed significantly higher expression of glycolytic transcripts in cirrhotic and HCC livers compared to normal quiescent livers (P < 0.05). Up regulation of Glut1, Hk1, Hk2, G6PI, and PFKLwas seen in HCC livers compared to their adjacent non-tumour tissues (P < 0.001). Notably, expression of enzymes regulating mitochondrial activity (Pdha, Pdk) was unchanged between non-tumour tissues and late stage of HCC. Moreover, up regulation of a novel anti-apoptotic gene positively correlated with increased expression of glycolytic transcripts in a group of cirrhotic patients prospectively classified as poor prognosis based on HCC development, and promotes the aerobic glycolysis of hepatoma cells. Conclusion: In summary, our findings delineate a putative link between aerobic glycolysis and suppression of apoptosis that is an important part of the progression of cirrhosis to HCC. The identification of the mechanism regulating this link may lead to design new therapeutic strategies for human liver disease

A Student-Led Campaign to Help Tackle Neglected Tropical Diseases

The authors propose that innovative student-led campaigns to address neglected diseases can and do make a practical difference

Young stars and non-stellar emission in the aligned radio galaxy 3C 256

We present ground-based images of the z=1.824 radio galaxy 3C 256 in the standard BVRIJHK filters and an interference filter centered at 8800A, a Hubble Space Telescope image in a filter dominated by Ly-alpha emission (F336W), and spectra covering rest-frame wavelengths from Ly-alpha to [O III] 5007. Together with published polarimetry observations, we use these to decompose the overall spectral energy distribution into nebular continuum emission, scattered quasar light, and stellar emission. The nebular continuum and scattered light together comprise half (one third) of the V-band (K-band) light within a 4-arcsec aperture, and are responsible for the strong alignment between the optical/near-infrared light and the radio emission. The stellar emission is dominated by a population estimated to be 100-200 Myr old (assuming a Salpeter IMF), and formed in a short burst with a peak star formation rate of 1-4x10^3 Msun/yr. The total stellar mass is estimated to be no more than 2x10^{11} Msun, which is far less than other luminous radio galaxies at similar redshifts, and suggests that 3C 256 will undergo further star formation or mergers.Comment: 35 pages including 10 figures; to appear in Nov 10 Ap

The black hole mass distribution in early-type galaxies: cusps in HST photometry interpreted through adiabatic black hole growth

The surface brightness profiles of early-type galaxies have central cusps. Two characteristic profile types are observed with HST: `core' profiles have a break at a resolved radius and logarithmic cusp slope gamma < 0.3 inside that radius; `power-law' profiles have no clear break and gamma > 0.3. With few exceptions, galaxies with M_V -20.5 have power-law profiles. Both profile types occur in galaxies with -22 < M_V < -20.5. We show that these results are consistent with the hypothesis that: (i) all early-type galaxies have black holes (BHs) that grew adiabatically in homogeneous isothermal cores; and (ii) these `progenitor' cores followed scaling relations similar to those of the fundamental plane. The models studied here are the ones first proposed by Young. Models with BH masses and progenitor cores that obey established scaling relations predict (at Virgo) that galaxies with M_V < -21.2 have core profiles and galaxies with M_V > -21.2 have power-law profiles. This reproduces both the sense and the absolute magnitude of the observed transition. Intrinsic scatter in BH and galaxy properties can explain why both types of galaxies are observed around the transition magnitude. The observed bimodality in cusp slopes may be due to a bimodality in M_bh/L, with rapidly rotating disky galaxies having larger M_bh/L than slowly rotating boxy galaxies. Application to individual galaxies with HST photometry yields a roughly linear correlation between BH mass and V-band galaxy luminosity, log M_bh = -1.83 + log L (solar units). This agrees with the average relation for nearby galaxies with kinematically determined BH masses, and also with predictions from quasar statistics (shortened abstract).Comment: 41 pages, LaTeX, with 11 PostScript figures. Submitted to the Astronomical Journal. Postscript version also available from http://sol.stsci.edu/~marel/abstracts/abs_R23.htm

A Perfusion Bioreactor for Longitudinal Monitoring of Bioengineered Liver Constructs

In the field of in vitro liver disease models, decellularised organ scaffolds maintain the original biomechanical and biological properties of the extracellular matrix and are established supports for in vitro cell culture. However, tissue engineering approaches based on whole organ decellularized scaffolds are hampered by the scarcity of appropriate bioreactors that provide controlled 3D culture conditions. Novel specific bioreactors are needed to support long-term culture of bioengineered constructs allowing non-invasive longitudinal monitoring. Here, we designed and validated a specific bioreactor for long-term 3D culture of whole liver constructs. Whole liver scaffolds were generated by perfusion decellularisation of rat livers. Scaffolds were seeded with Luc+HepG2 and primary human hepatocytes and cultured in static or dynamic conditions using the custom-made bioreactor. The bioreactor included a syringe pump, for continuous unidirectional flow, and a circuit built to allow non-invasive monitoring of culture parameters and media sampling. The bioreactor allowed non-invasive analysis of cell viability, distribution, and function of Luc+HepG2-bioengineered livers cultured for up to 11 days. Constructs cultured in dynamic conditions in the bioreactor showed significantly higher cell viability, measured with bioluminescence, distribution, and functionality (determined by albumin production and expression of CYP enzymes) in comparison to static culture conditions. Finally, our bioreactor supports primary human hepatocyte viability and function for up to 30 days, when seeded in the whole liver scaffolds. Overall, our novel bioreactor is capable of supporting cell survival and metabolism and is suitable for liver tissue engineering for the development of 3D liver disease models

Self-medication amongst pregnant women in a tertiary care teaching hospital in India

Background: Self-medication is a popular practice in developing countries where there is no strict regulation of drugs sold in local pharmacies. General public is usually unaware of the adverse effects of drugs used for common illness and continue using them without prescription during pregnancy. This study was carried out to know the extent of self-medication practised by pregnant women and various factors associated with it.Methods: A questionnaire based, cross-sectional study of pregnant women visiting the OB GYN-OPD of a tertiary care teaching hospital was conducted. 303 eligible subjects were questioned and statistical analysis was carried out.Results: Total 16.5% women were found to be self-medicating during pregnancy for common conditions like headache (26%), fever (23%) and common cold (19%). Odds Ratio between the self-medicating and non-self-medicating groups for variables like age (<25 years; ≥25 years), education (illiterate; literate) and gestational age (<20 weeks; ≥20 weeks) are 1.6, 2 and 1.73 respectively. Women with a history of self-medicating before pregnancy were significantly more likely to continue doing so during pregnancy (p value <0.00001).Conclusions: A significant proportion of pregnant women have been found to self-medicate without knowing the adverse effects of the drug used. Thus, spreading awareness against this health-predicament is necessary

Massive Ellipticals at High Redshift: NICMOS Imaging of Z~1 Radio Galaxies

We present deep, continuum images of eleven high-redshift (0.811 < z < 1.875) 3CR radio galaxies observed with NICMOS. Our images probe the rest-frame optical light where stars are expected to dominate the galaxy luminosity. The rest-frame UV light of eight of these galaxies demonstrates the well-known ``alignment effect''. Most of the radio galaxies have rounder, more symmetric morphologies at rest-frame optical wavelengths. Here we show the most direct evidence that in most cases the stellar hosts are normal elliptical galaxies with de Vaucouleurs law light profiles. For a few galaxies very faint traces of the UV-bright aligned component are also visible in the infrared images. We derive both the effective radius and surface-brightness for nine of eleven sample galaxies by fitting surface-brightness models to them. We find their sizes are similar to those of local FRII radio source hosts and are in general larger than other local galaxies. The derived host galaxy luminosities are very high and lie at the bright end of luminosity functions constructed at similar redshifts. The galaxies in our sample are also brighter than the rest-frame size--surface-brightness locus defined by the low-redshift sources. Passive evolution roughly aligns the z ~ 1 galaxies with the low-redshift samples. The optical host is sometimes centered on a local minimum in the rest-frame UV emission, suggesting the presence of substantial dust obscuration. We also see good evidence of nuclear point sources in three galaxies. Overall, our results are consistent with the hypothesis that these galaxies have already formed the bulk of their stars at redshifts greater than z >~ 2, and that the AGN phenomenon takes place within otherwise normal, perhaps passively evolving, galaxies. (abridged)Comment: 28 pages, 14 figures, accepted to ApJ. Uses AASTEX and emulateapj