1,1,2,2-Tetra­kis(diisopropyl­amino)diphosphane

In the title compound, C24H56N4P2, the distance between the P atoms [2.2988 (8) and 2.3013 (13) Å in the major and minor occupancy components, respectively] is one of the longest reported for uncoordinated diphosphanes. The whole mol­ecule is disordered over two positions with site-occupation factors of 0.6447 (8) and 0.3553 (8). The structure adopts the synperiplanar conformation in the solid state [N—P—P—N torsion angle = 14.7 (5)°]

N-(4-Methyl­piperazin-4-ium-1-yl)dithio­carbamate sesquihydrate

In the crystal structure of the title compound, C6H13N3S2·1.5H2O, weak N—H⋯S inter­actions between the zwitterionic mol­ecules are observed, leading to an extensively folded layered arrangement parallel to (100). There are three crystallographically independent water mol­ecules in the asymmetric unit, which are disordered and only half occupied

Tetra-n-butyl­ammonium iodido(pyrrolidine-1-carbodithio­ato-κ2 S,S′)(tris-tert-butoxy­silanethiol­ato-κS)cadmate(II)

In the anion of the title compound, (C16H36N)[Cd(C5H8NS2)(C12H27O3SSi)I], the Cd atom is four-coordinated by S,S′-chelating dithio­carbamate, S–donating silanethiol­ate and iodide ligands in a distorted tetrahedral environment . Inter­molecular C—H⋯ S and C—H⋯I inter­actions between cations and anions are present. Two C atoms of a tert-butyl group are disordered over two positions; the site occupancies are ca 0.65 and 0.35

Redetermination of bis­(O,O′-diethyl dithio­phosphato-κ2 S,S′)nickel(II)

The centrosymmetric title complex, [Ni{S2P(OC2H5)2}2], has been redetermined using area-detector data. The central Ni(S2P)2 core is essentially planar and confirms the early results of McConnell & Kastalsky [Acta Cryst. (1967), 22, 853–859] based on multiple film technique data. In the title structure, the standard uncertainty values are approximately seven times lower and all H-atom positions are calculated. A pair of short symmetry-related H⋯H contacts with distances of 2.33 Å is observed in the crystal structure

Modeling of Dolichol Mass Spectra Isotopic Envelopes as a Tool to Monitor Isoprenoid Biosynthesis1

The cooperation of the mevalonate (MVA) and methylerythritol phosphate (MEP) pathways, operating in parallel in plants to generate isoprenoid precursors, has been studied extensively. Elucidation of the isoprenoid metabolic pathways is indispensable for the rational design of plant and microbial systems for the production of industrially valuable terpenoids. Here, we describe a new method, based on numerical modeling of mass spectra of metabolically labeled dolichols (Dols), designed to quantitatively follow the cooperation of MVA and MEP reprogrammed upon osmotic stress (sorbitol treatment) in Arabidopsis (Arabidopsis thaliana). The contribution of the MEP pathway increased significantly (reaching 100%) exclusively for the dominating Dols, while for long-chain Dols, the relative input of the MEP and MVA pathways remained unchanged, suggesting divergent sites of synthesis for dominating and long-chain Dols. The analysis of numerically modeled Dol mass spectra is a novel method to follow modulation of the concomitant activity of isoprenoid-generating pathways in plant cells; additionally, it suggests an exchange of isoprenoid intermediates between plastids and peroxisomes

Konsensus dotyczący zastosowania leków hamujących wydzielanie kwasu solnego w żołądku w najczęstszych chorobach górnego odcinka przewodu pokarmowego w praktyce lekarza podstawowej opieki zdrowotnej

Niniejszy artykuł ma charakter konsensusu i dotyczy zastosowania leków antysekrecyjnych w leczeniu najczęstszych chorób górnego odcinka przewodu pokarmowego w praktyce lekarza podstawowej opieki zdrowotnej. Dwadzieścia sześć stwierdzeń, które stanowią podsumowanie obecnego stanu wiedzy na ten temat, zostało poddanych głosowaniu przez członków Zarządu Głównego Polskiego Towarzystwa Gastroenterologii (ZG PTG-E). Celem głosowania była ocena stopnia akceptacji poszczególnych stwierdzeń i gotowości do ich zalecania w polskich warunkach. Dwadzieścia jeden z 26 stwierdzeń zostało zaakceptowanych w całości lub jedynie z pewnym zastrzeżeniem (stopień poparcia A lub B) przez co najmniej 85% głosujących, a kolejne 3 uzyskały poparcie wynoszące co najmniej 74%. Wysoki stopień poparcia większości stwierdzeń zawartych w konsensusie przez członków ZG PTG-E upoważnia do stwierdzenia, że przedstawione w nim zasady wykorzystania leków antysekrecyjnych mogą być rekomendowane w praktyce lekarzy podstawowej opieki zdrowotnej w Polsce. Gastroenterologia Kliniczna 2009, tom 1, nr 1, 1-

Integracja metodyki obiek­towej opartej na zastosowaniu języka UML ze środowiskiem programistycz­nym Borland C++ Builder

This article presents the description of the concepts, design and implementation of the component library created by the authors of the article for the Borland C++ IDE. The library enables programmer to separate the business functions from the database integration and the GUI functions.W artykule podjęto próbę rozwiązania problemu integracji modelu obiektowego systemu informatycznego z częścią realizującą funkcje interfejsu dla relacyjnej bazy danych, a także częścią odpowiedzialną za obsługę graficznego interfejsu użytkownika. Opisywane rozwiązanie dotyczy platformy Borland C++ Builder. Opracowane zostały projekt i implementacja biblioteki komponentów nazwanej skrótem BMU (od ang. Business Model Utility)

Novel Diazocrowns with Pyrrole Residue as Lead(II)Colorimetric Probes

Novel 18- and 23-membered diazomacrocycles were obtained with satisfactory yields by diazocoupling of aromatic diamines with pyrrole in reactions carried under high dilution conditions. X-ray structure of macrocycle bearing five carbon atoms linkage was determined and described. Compounds were characterized as chromogenic heavy metal ions receptors. Selective color and spectral response for lead(II) was found in acetonitrile and its mixture with water. Complexation properties of newly obtained macrocycles with a hydrocarbon chain were compared with the properties of their oligoether analogs. The influence of the introduction of hydrocarbon residue as a part of macrocycle on the lead(II) binding was discussed. Selective and sensitive colorimetric probe for lead(II) in aqueous acetonitrile with detection limit 56.1 μg/L was proposed

Application of nonmetallic frustrated cations in the activation of small molecules

The concept of nonmetallic frustrated cations has been used in the small molecule activation. The in situ generated ambiphilic phosphinoborinium cation activated phenyl isocyanate, diisopropylcarbodiimide, and acetonitrile under very mild conditions without any catalyst, yielding single-, double-, or mixed-activation products. Furthermore, the mechanisms of the reactions of the phosphinoborinium cation with small molecules were elucidated using density functional theory calculations