Homocysteine-induced peripheral microcirculation dysfunction in zebrafish and its attenuation by L-arginine

Elevated blood homocysteine (Hcy) level is frequently observed in aged individuals and those with age-related vascular diseases. However, its effect on peripheral microcirculation is still not fully understood. Using in vivo zebrafish model, the degree of Hcy-induced peripheral microcirculation dysfunction is assessed in this study with a proposed dimensionless velocity parameter (V) over bar (CV)/(V) over bar (PCV), where (V) over bar (CV) and (V) over bar (PCV) represent the peripheral microcirculation perfusion and the systemic perfusion levels, respectively. The ratio of the peripheral microcirculation perfusion to the systemic perfusion is largely decreased due to peripheral accumulation of neutrophils, while the systemic perfusion is relatively preserved by increased blood supply from subintestinal vein. Pretreatment with L-arginine attenuates the effects of Hcy on peripheral microcirculation and reduces the peripheral accumulation of neutrophils. Given its convenience, high reproducibility of the observation site, non-invasiveness, and the ease of drug treatment, the present zebrafish model with the proposed parameters will be used as a useful drug screening platform for investigating the pathophysiology of Hcy-induced microvascular diseases.111Ysciescopu

Microfluidic system for monitoring temporal variations of hemorheological properties and platelet adhesion in LPS-injected rats

Sepsis causes multiple organs failures and eventually death. Changes in blood constituents due to sepsis lead to alterations in hemorheological properties, and cell adhesiveness. In this study, a new microfluidic system is proposed to measure temporal variations in biophysical properties of blood after injecting lipopolysaccharide (LPS) into a rat extracorporeal model under ex vivo condition. To measure blood viscosity, the interfacial line between blood and a reference fluid is formed in a Y-shaped channel. Based on the relation between interfacial width and pressure ratio, the temporal variation in blood viscosity is estimated. Optical images of blood flows are analyzed by decreasing flow rate for examination of red blood cell (RBC) aggregation. Platelets initiated by shear acceleration around the stenosis adhere to the post-stenosed region. By applying a correlation map that visualizes the decorrelation of the streaming blood flow, the area of adhered platelets can be quantitatively attained without labeling of platelets. To assess sepsis inflammation, conventional biomarkers (PCT and IL-8) are also monitored. The increasing tendency for blood viscosity, RBC aggregation, platelet adhesion, and septic biomarkers are observed after LPS injection. This microfluidic system would be beneficial for monitoring the changes in hemorheological properties and platelet activation caused by sepsis.116Ysciescopu

WISDOM Project -- XV. Giant Molecular Clouds in the Central Region of the Barred Spiral Galaxy NGC 5806

We present high spatial resolution ($\approx24$ pc) Atacama Large Millimeter/sub-millimeter Array $^{12}$CO(2-1) observations of the central region of the nearby barred spiral galaxy NGC 5806. NGC 5806 has a highly structured molecular gas distribution with a clear nucleus, a nuclear ring and offset dust lanes. We identify $170$ spatially- and spectrally-resolved giant molecular clouds (GMCs). These clouds have comparable sizes ($R_{\mathrm{c}}$) and larger gas masses, observed linewidths ($\sigma_{\mathrm{obs,los}}$) and gas mass surface densities than those of clouds in the Milky Way disc. The size -- linewidth relation of the clouds is one of the steepest reported so far ($\sigma_{\mathrm{obs,los}}\propto R_{\mathrm{c}}^{1.20}$), the clouds are on average only marginally bound (with a mean virial parameter $\langle\alpha_{\mathrm{vir}}\rangle\approx2$), and high velocity dispersions are observed in the nuclear ring. These behaviours are likely due to bar-driven gas shocks and inflows along the offset dust lanes, and we infer an inflow velocity of $\approx120$ kms$^{-1}$ and a total molecular gas mass inflow rate of $\approx5$ M$_\odot$ yr$^{-1}$ into the nuclear ring. The observed internal velocity gradients of the clouds are consistent with internal turbulence. The number of clouds in the nuclear ring decreases with azimuthal angle downstream from the dust lanes without clear variation of cloud properties. This is likely due to the estimated short lifetime of the clouds ($\approx6$ Myr), which appears to be mainly regulated by cloud-cloud collision and/or shear processes. Overall, it thus seems that the presence of the large-scale bar and gas inflows to the centre of NGC 5806 affect cloud properties.Comment: Accepted for publication in MNRAS, 20 pages, 16 figure

WISDOM Project - X. The morphology of the molecular ISM in galaxy centres and its dependence on galaxy structure

We use high-resolution maps of the molecular interstellar medium (ISM) in the centres of 86 nearby galaxies from the millimetre-Wave Interferometric Survey of Dark Object Masses (WISDOM) and Physics at High Angular Resolution in Nearby GalaxieS (PHANGS) surveys to investigate the physical mechanisms setting the morphology of the ISM at molecular cloud scales. We show that early-type galaxies tend to have smooth, regular molecular gas morphologies, while the ISM in spiral galaxy bulges is much more asymmetric and clumpy when observed at the same spatial scales. We quantify these differences using non-parametric morphology measures (Asymmetry, Smoothness, and Gini), and compare these measurements with those extracted from idealized galaxy simulations. We show that the morphology of the molecular ISM changes systematically as a function of various large-scale galaxy parameters, including galaxy morphological type, stellar mass, stellar velocity dispersion, effective stellar mass surface density, molecular gas surface density, star formation efficiency, and the presence of a bar. We perform a statistical analysis to determine which of these correlated parameters best predicts the morphology of the ISM. We find the effective stellar mass surface (or volume) density to be the strongest predictor of the morphology of the molecular gas, while star formation and bars maybe be important secondary drivers. We find that gas self-gravity is not the dominant process shaping the morphology of the molecular gas in galaxy centres. Instead effects caused by the depth of the potential well, such as shear, suppression of stellar spiral density waves, and/or inflow, affect the ability of the gas to fragment

불안정성 협착증 주변의 유동 특성

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Enhancement of stability of superhydrophobic surface by controlling its structure and flexibility

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단일 캐비티에 함침된 윤활유의 유실에 대한 실험적 연구

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The geometrical effect on the shear-induced lubricant depletion for a 3D cavity

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Ridge 구조를 가진 초소수성 표면에서 나노 구조가 공기층과 항력감소에 미치는 효과 연구

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초소수성 표면의 구조 및 탄성도가 공기층 안정성에 미치는 효과

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