Myotonic Dystrophy Mimicking Postpolio Syndrome in a Polio Survivor

We describe a 38-yr-old polio survivor with newly developed weakness from myotonic dystrophy. He suffered muscle atrophy and weakness in his legs as a result of poliomyelitis at the age of 3 yrs. After a stable interval of about 30 yrs, he felt new weakness and fatigue in his legs. Electromyography revealed generalized myotonic discharges, early recruitment, and findings of chronic denervation in his left leg. Genetic testing was consistent with myotonic dystrophy type 1. A biopsy from the right gastrocnemius revealed findings of both myotonic dystrophy and chronic denervation. This case report shows the importance of considering other uncommon conditions in the differential diagnoses of postpolio syndrome

More Than Accuracy: Towards Trustworthy Machine Learning Interfaces for Object Recognition

This paper investigates the user experience of visualizations of a machine learning (ML) system that recognizes objects in images. This is important since even good systems can fail in unexpected ways as misclassifications on photo-sharing websites showed. In our study, we exposed users with a background in ML to three visualizations of three systems with different levels of accuracy. In interviews, we explored how the visualization helped users assess the accuracy of systems in use and how the visualization and the accuracy of the system affected trust and reliance. We found that participants do not only focus on accuracy when assessing ML systems. They also take the perceived plausibility and severity of misclassification into account and prefer seeing the probability of predictions. Semantically plausible errors are judged as less severe than errors that are implausible, which means that system accuracy could be communicated through the types of errors.Comment: UMAP '20: Proceedings of the 28th ACM Conference on User Modeling, Adaptation and Personalizatio

Living in a glass house: a survey of private moments in the home

ABSTRACT As advances in technology accelerate, sensors and recording devices are increasingly being integrated into homes. Although the added benefit of sensing is often clear (e.g., entertainment, security, encouraging sustainable behaviors, etc.), the home is a private and intimate place, with multiple stakeholders who may have competing priorities and tolerances for what is acceptable and useful. In an effort to develop systems that account for the needs and concerns of householders, we conducted an anonymous survey (N = 475) focusing on the activities and habits that people do at home that they would not want to be recorded. In this paper, we discuss those activities and where in the home they are performed, and offer suggestions for the design of UbiComp systems that rely on sensing and recording

Econundrum:Visualizing the Climate Impact of Dietary Choice through a Shared Data Sculpture

While there is a strong relationship between climate change and human food consumption, it is challenging to understand the implications and impact from an individual perspective. The lack of a shared frame of reference, that allows people to compare their impact to others, limits awareness on this complex topic. To support group reflections and social comparison of the impact of people’s food consumption on climate change, we designed Econundrum, a shared physical data sculpture that visualizes carbon emissions resulting from dietary choices of a small community. Our three-week field study demonstrates how Econundrum helped people (i) understand the climate impact of various food types, (ii) reflect on the environmental impact of their food choices; and (iii) discuss the relation between climate impact and food consumption with others. Our study shows how a shared physical data sculpture mediates a complex topic to a community by facilitating the social dynamics in context

Programming effects of maternal stress on the circadian system of adult offspring

Maternal stress has long-lasting influences on the brain functions of offspring, and several brain regions have been proposed to mediate such programming. Although perinatal programming of crosstalk between the circadian and stress systems has been proposed, the functional consequences of prenatal stress on the circadian system and the underlying mechanisms remain largely unknown. Therefore, we investigated whether exposing pregnant mice to chronic restraint stress had prolonged effects on the suprachiasmatic nucleus (SCN), which bears the central pacemaker for mammalian circadian rhythms, of offspring. SCN explants from maternally stressed mice exhibited altered cyclic expression patterns of a luciferase reporter under control of the mouse Per1 promoter (mPer1::LUC), which manifested as a decreased amplitude and impaired stability of the rhythm. Bioluminescence imaging at the single-cell level subsequently revealed that impaired synchrony among individual cells was responsible for the impaired rhythmicity. These intrinsic defects appeared to persist during adulthood. Adult male offspring from stressed mothers showed advanced-phase behavioral rhythms with impaired stability as well as altered clock gene expression in the SCN. In addition to affecting the central rhythm, maternal stress also had prolonged influences on the circadian characteristics of the adrenal gland and liver, as determined by circulating corticosterone levels and hepatic glycogen content, and on canonical clock gene mRNA expression in those tissues. Taken together, our findings suggest that the SCN is a key target of the programming effects of maternal stress. The widespread effects of circadian disruptions caused by a misprogrammed clock may have further impacts on metabolic and mental health in later life. © 2020, The Author(s).1

MYC quantitation in cell-free plasma DNA by real-time PCR for gastric cancer diagnosis

Background: Detection of tumor-associated genetic alterations in plasma of cancer patients has recently been suggested to be an accurate method for detecting early or recurrent cancer. Methods: We performed quantitative real-time PCR for MYC and GAPDH in tissue and plasma samples of 57 patients with gastric cancer and in plasma of 79 cancer-free individuals. We also performed two-color MYC fluorescence in situ hybridization (FISH) in tissue from the 57 patients with gastric cancer. Results: The tissue MYC/GAPDH ratio by real-time PCR was significantly correlated with MYC status by FISH (p<0.001). The mean ratio of plasma MYC/GAPDH was 5.226+/-3.578 (range: 1.25-18.35) in gastric cancer patients, and 2.436+/-0.881 (range: 1.00-5.00) in the healthy volunteers (p<0.001). We used receiver-operating characteristics (ROC) curve analysis to select two optimal plasma MYC/GAPDH cut-offs of 2.725 and 5.225. The sensitivity and specificity were 75.4% and 76.9% at 2.725, 38.6% and 100% at 5.225, respectively. The plasma MYC/GAPDH ratio from cancer patients was significantly correlated with the tissue MYC/GAPDH ratio (p=0.009), and tissue MYC status by FISH (p=0.024). Conclusions: These findings suggest that the plasma MYC/GAPDH ratio, as determined by real-time PCR, may be an alternative non-invasive approach for detecting gastric cancer. Clin Chem Lab Med 2009; 47:530-6.Kim MA, 2007, HUM PATHOL, V38, P1386, DOI 10.1016/j.humpath.2007.02.005Sai S, 2007, ANTICANCER RES, V27, P2747Mitsui F, 2007, MODERN PATHOL, V20, P622, DOI 10.1038/modpathol.3800777Vita M, 2006, SEMIN CANCER BIOL, V16, P318, DOI 10.1016/j.semcancer.2006.07.015Corzo C, 2006, CANCER GENET CYTOGEN, V165, P151, DOI 10.1016/j.cancergencyto.2005.08.013Crew KD, 2006, WORLD J GASTROENTERO, V12, P354Calcagno DQ, 2005, ANTICANCER RES, V25, P4069Gotoh T, 2005, J CLIN ONCOL, V23, P5205, DOI 10.1200/JCO.2005.02.014Tse C, 2005, CLIN CHEM, V51, P1093, DOI 10.1373/clinchem.2004.044305Kindich R, 2005, CLIN CHEM, V51, P649, DOI 10.1373/clinchem.2004.045013Lee TL, 2002, CLIN CANCER RES, V8, P1761Usadel H, 2002, CANCER RES, V62, P371*AM JOINT COMM CAN, 2002, AJCC CANC STAG MAN, P99Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262Lee HS, 2001, CANCER, V92, P1427Lo YMD, 2001, CLIN CANCER RES, V7, P1856Koo SH, 2000, CANCER GENET CYTOGEN, V117, P97AALTONEN LA, 2000, INT AGENCY RES CANC, P37Castells A, 1999, J CLIN ONCOL, V17, P578Hara T, 1998, LAB INVEST, V78, P1143Landis SH, 1998, CA-CANCER J CLIN, V48, P6Suzuki S, 1997, J SURG ONCOL, V66, P173Nawroz H, 1996, NAT MED, V2, P1035Henriksson M, 1996, ADV CANCER RES, V68, P109PARK JG, 1990, CANCER RES, V50, P2773STROUN M, 1989, ONCOLOGY, V46, P318LAUREN P, 1965, ACTA PATHOL MIC SC, V64, P31

Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study

Background: Regulation of tumor microenvironment is closely involved in the prognosis of Hodgkin lymphoma (HL). Indoleamine 2,3-dioxygenase (IDO) is an enzyme acting as immune modulator through suppression of T-cell immunity. This study aims to investigate role of IDO in the microenvironment of HL. Methods: A total of 121 cases of HL were enrolled to do immunohistochemistry for IDO, CD163, CD68, CD4, CD8, and FoxP3. Positivity was evaluated from area fractions or numbers of positive cells using automated image analyzer. Correlations between IDO expression and various cellular infiltrates and clinicopathologic parameters were examined and survival analyses were performed. Results: IDO was expressed in histiocytes, dendritic cells and some endothelial cells with variable degrees, but not in tumor cells. IDO positive cells were more frequently found in mixed cellularity type than other histologic types, and in cases with EBV+, high Ann Arbor stages, B symptoms, and high IPS (all p < 0.05). High IDO expression was associated with inferior survival (p < 0.001) and reflects an independent prognostic factor in nodular sclerosis HL. Conclusions: This is the first study suggesting that IDO is the principle immunomodulator and is involved to adverse clinical outcomes of HL.Peer Reviewe

A Huge Mediastinal Organizing Hematoma Causing Reversal of Atrial Septal Defect Shunt Flow

We report a case of a 46-year-old woman who presented with subacute exertional dyspnea and severe hypoxia. A large cystic mass compressing the right side of the heart along with right-to-left atrial shunt flow through an alleged atrial septal defect (ASD) were detected on echocardiography. CT scan of the chest and MRI of the heart revealed a loculated cystic mediastinal mass with hemorrhage measuring 5.5×8 cm compressing the right atrium and ventricle. The patient underwent cyst resection and primary closure of the ASD. This report illustrates a case of an unusual symptomatic pericardial mass compressing the right atrium and ventricle in a patient with an secundum ASD