Cosmological constant from gauge fields on extra dimensions

We present a new model of dark energy which could explain the observed accelerated expansion of our Universe. We show that a five-dimensional Einstein-Yang-Mills theory defined in a flat Friedmann-Robertson-Walker universe compactified on a circle possesses degenerate vacua in four dimensions. The present Universe could be trapped in one of these degenerate vacua. With the natural requirement that the size of the extra dimension could be of the GUT scale or smaller, the energy density difference between the degenerate vacua and the true ground state can provide us with just the right amount of dark energy to account for the observed expansion rate of our Universe.Comment: 5 pages, minor change

Scalar field fluctuations in Schwarzschild-de Sitter space-time

We calculate quantum fluctuations of a free scalar field in the Schwarzschild-de Sitter space-time, adopting the planar coordinates that is pertinent to the presence of a black hole in an inflationary universe. In a perturbation approach, doing expansion in powers of a small black hole event horizon compared to the de Sitter cosmological horizon, we obtain time evolution of the quantum fluctuations and then derive the scalar power spectrum.Comment: 16 pages and 4 figures, accepted by Classical and Quantum Gravit

The Transformation of Trust in China’s Alternative Food Networks: Disruption, Reconstruction, and Development

Food safety issues in China have received much scholarly attention, yet few studies systematically examined this matter through the lens of trust. More importantly, little is known about the transformation of different types of trust in the dynamic process of food production, provision, and consumption. We consider trust as an evolving interdependent relationship between different actors. We used the Beijing County Fair, a prominent ecological farmers’ market in China, as an example to examine the transformation of trust in China’s alternative food networks. We argue that although there has been a disruption of institutional trust among the general public since 2008 when the melamine-tainted milk scandal broke out, reconstruction of individual trust and development of organizational trust have been observed, along with the emergence and increasing popularity of alternative food networks. Based on more than six months of fieldwork on the emerging ecological agriculture sector in 13 provinces across China as well as monitoring of online discussions and posts, we analyze how various social factors—including but not limited to direct and indirect reciprocity, information, endogenous institutions, and altruism—have simultaneously contributed to the transformation of trust in China’s alternative food networks. The findings not only complement current social theories of trust, but also highlight an important yet understudied phenomenon whereby informal social mechanisms have been partially substituting for formal institutions and gradually have been building trust against the backdrop of the food safety crisis in China

Transverse Bragg-reflector injection lasers

A GaAs-GaAlAs injection laser has been tested that confines light in the lateral dimension (normal to junction plane) by a multilayer Bragg reflector. In the past, light has been confined as a result of the higher-index guiding region and resulting evanescent fields

Supercurves

The TST-dual of the general 1/4-supersymmetric D2-brane supertube is identified as a 1/4-supersymmetric IIA `supercurve': a string with arbitrary transverse displacement travelling at the speed of light. A simple proof is given of the classical upper bound on the angular momentum, which is also recovered as the semi-classical limit of a quantum bound. The classical bound is saturated by a `superhelix', while the quantum bound is saturated by a bosonic oscillator state in a unique SO(8) representation.Comment: 1+14 pages, LaTe

Atypical breasts cancers

AbstractIntroductionWith increasing incidence of breast cancers there are now a larger number of cases diagnosed with rare malignancies. These can be diagnostic dilemmas and management strategy can be different by various breast multi-disciplinary teams (MDT).We aim to discuss the evidence-based approach for management of these atypical breast cancers which were identified in patients from a single breast screening unit.MethodPatient with unusual breast malignancies (all types except invasive ductal and lobular) treated under the care of a single surgeon were identified during the breast multi-disciplinary discussion from 2011 to 2015. The histology and management of these cases were reviewed and literature search of electronic databases via PubMed and the search engines Google/Google Scholar was performed. Emphasis on keywords based on the histology type was used to limit search. Search was focused on the diagnosis, management and prognosis of these unusual breast cancers.ConclusionThis series aims to focus on the evidence-based management of these rare breast malignancies; the diagnosis of which is crucial as it affects the overall treatment and prognosis

Predicting Out-of-Domain Generalization with Local Manifold Smoothness

Understanding how machine learning models generalize to new environments is a critical part of their safe deployment. Recent work has proposed a variety of complexity measures that directly predict or theoretically bound the generalization capacity of a model. However, these methods rely on a strong set of assumptions that in practice are not always satisfied. Motivated by the limited settings in which existing measures can be applied, we propose a novel complexity measure based on the local manifold smoothness of a classifier. We define local manifold smoothness as a classifier's output sensitivity to perturbations in the manifold neighborhood around a given test point. Intuitively, a classifier that is less sensitive to these perturbations should generalize better. To estimate smoothness we sample points using data augmentation and measure the fraction of these points classified into the majority class. Our method only requires selecting a data augmentation method and makes no other assumptions about the model or data distributions, meaning it can be applied even in out-of-domain (OOD) settings where existing methods cannot. In experiments on robustness benchmarks in image classification, sentiment analysis, and natural language inference, we demonstrate a strong and robust correlation between our manifold smoothness measure and actual OOD generalization on over 3,000 models evaluated on over 100 train/test domain pairs.Comment: 18 pages, 3 figure

Mixtures of Regression Models for Time-Course Gene Expression Data: Evaluation of Initialization and Random Effects

Finite mixture models are routinely applied to time course microarray data. Due to the complexity and size of this type of data the choice of good starting values plays an important role. So far initialization strategies have only been investigated for data from a mixture of multivariate normal distributions. In this work several initialization procedures are evaluated for mixtures of regression models with and without random effects in an extensive simulation study on different artificial datasets. Finally these procedures are also applied to a real dataset from E. coli

The Use of Medicinal Mushroom or Herb as Effective Immunomodulatory Agent

Background: Medicinal mushrooms are mushrooms used with the aim for health enhancement. They have been used in traditional Chinese medicine (TCM) for thousands of years. These mushrooms and some herbal medicines have gain in popularity in recent times, largely due to a growing number of scientific studies that suggest their potential medical benefits. They are found to exert immunomodulatory effects through changes in the quantity of some specific cytokines in blood; as well as numbers and activities of distinct immune cell subsets. This article summarizes the immunomodulatory effects of two commonly consumed medicinal mushrooms (Coriolus versicolor and Ganoderma lucidum) and also three herbal medicines that have been categorized as immunomodulatory in function (Cordyceps sinensis, Astragalus membranaceus and Eleutherococcus senticosus). Methods: A systematic search of published articles of clinical trial studies between 1985 and August 2015 was conducted in four electronic databases (EMBASE, PubMed, Scopus and Web of Science). The outcome measures included changes in the serum cytokines secretion and the number and functional activity of different immune cell populations. Results: After a thorough literature searching of 237 relevant articles, 15 were included. Coriolus versicolor and Ganoderma lucidum showed immunomodulatory effects in both innate and adaptive immunity arms. There are only very few studies in each mushroom or herb, and unequivocal conclusions cannot be drawn. Future larger trials of randomized and placebo controlled clinical studies with laboratory investigation of changes of multiple immune populations and their subsets are needed in consistent with an evidence-based medicine approach