Hydrothermally treated coral scaffold promotes proliferation of mesenchymal stem cells and enhances segmental bone defect healing

Introduction: Synthetic hydroxyapatite (HAp) scaffolds have shown promising therapeutic outcomes in both animals and patients. In this study, we aim to evaluate the chemical and physical phenotype, biocompatibility, and bone repair effects of hydrothermally treated coral with natural coral and synthetic HAp.Methods: The phase composition, surface pattern, 3D structures, and porosity of the scaffolds were characterized, and cell viability, proliferation, and osteogenic differentiation of mesenchymal stem cells (MSCs) after seeding onto the scaffold were determined. The scaffolds were implanted into rats to assess their bone repair effects using micro-CT analysis, mechanical testing, and histological staining.Results: The results showed that the phase composition, porous structure, and porosity of hydrothermally treated coral were comparable to pure HAp scaffold. While only the natural coral happens to be dominantly calcium carbonate. Higher cell proliferation and osteogenic differentiation potential were observed in the hydrothermally treated coral scaffold compared to natural coral and pure HAp. Histological results also showed increased new bone formation in the hydrothermally treated coral group.Discussion: Overall, our study suggests that hydrothermal modification enhances the cytocompatibility and therapeutic capacity of coral without altering its physical properties, showing superior effectiveness in bone repair to synthetic HAp

The First Very Long Baseline Interferometry Image of 44 GHz Methanol Maser with the KVN and VERA Array (KaVA)

We have carried out the first very long baseline interferometry (VLBI) imaging of 44 GHz class I methanol maser (7_{0}-6_{1}A^{+}) associated with a millimeter core MM2 in a massive star-forming region IRAS 18151-1208 with KaVA (KVN and VERA Array), which is a newly combined array of KVN (Korean VLBI Network) and VERA (VLBI Exploration of Radio Astrometry). We have succeeded in imaging compact maser features with a synthesized beam size of 2.7 milliarcseconds x 1.5 milliarcseconds (mas). These features are detected at a limited number of baselines within the length of shorter than approximately 650 km corresponding to 100 Mlambda in the uv-coverage. The central velocity and the velocity width of the 44 GHz methanol maser are consistent with those of the quiescent gas rather than the outflow traced by the SiO thermal line. The minimum component size among the maser features is ~ 5 mas x 2 mas, which corresponds to the linear size of ~ 15 AU x 6 AU assuming a distance of 3 kpc. The brightness temperatures of these features range from ~ 3.5 x 10^{8} to 1.0 x 10^{10} K, which are higher than estimated lower limit from a previous Very Large Array observation with the highest spatial resolution of ~ 50 mas. The 44 GHz class I methanol maser in IRAS 18151-1208 is found to be associated with the MM2 core, which is thought to be less evolved than another millimeter core MM1 associated with the 6.7 GHz class II methanol maser.Comment: 19 pages, 3 figure

Optimal Scheduling for the Complementary Energy Storage System Operation Based on Smart Metering Data in the DC Distribution System

The increasing penetration of distributed generation (DG) sources in low-voltage grid feeders causes problems concerning voltage regulation. The penetration of DG sources such as photovoltaics (PVs) in the distribution system can significantly impact the power flow and voltage conditions on the customer side. As the DG sources are more commonly connected to low-voltage distribution systems, voltage fluctuations in the distribution system are experienced because of the DG fluctuation and uncertainty. Therefore, the penetration of DGs in distribution systems is often limited by the required operating voltage ranges. By using an energy storage system (ESS), voltage fluctuation can be compensated for, thus satisfying the voltage regulation requirements. This paper presents an ESS scheduling algorithm based on the power injection data obtained from a smart metering system. The proposed ESS scheduling algorithm is designed for use within a direct current (DC) distribution grid, which comprises customers, each with a PV and an ESS system. The purpose of this ESS scheduling algorithm is to optimize the ESS scheduling by considering the complementary operation among all the ESSs

Anisotropic Metamagnetic Spin Reorientation and Rotational Magnetocaloric Effect of Single Crystal NdAlGe

Magnetic anisotropy strongly influences the performance of the magnetocaloric effect. We investigated the magnetocaloric properties of the NdAlGe single crystal with I41md structure. The temperature-dependent magnetization revealed significant anisotropic properties; stable antiferromagnetic transition at TN = 6 K for H//a and meta-magnetic spin reorientation at low temperature (T ≤ 5 K) within an intermediate field (H = 2 T) for H//c. During the metamagnetic spin reorientation, the abrupt change of the magnetic entropy leads to a significant magnetocaloric effect with negative magnetic entropy change (∆SM) by −13.80 J kg−1 K−1 at TC = 5.5 K for H = 5 T along the H//c axis. In addition, the antiferromagnetic state for H//a shows the inverse magnetocaloric effect(I-MCE) by positive entropy change ∆SM = 2.64 J kg−1 K−1 at TN = 6 K for H = 5 T. This giant MCE accompanied by the metamagnetic transition resulted in a significantly large relative cooling power (158 J/kg at H = 5 T) for H//c. The giant MCE and I-MCE can be applied to the rotational magnetocaloric effect (R-MCE) depending on the crystal orientations. NdAlGe exhibits rotational entropy change ∆Sc−a = −12.85 J kg−1 K at Tpeak = 7.5 K, H = 5 T. With comparison to conventional MCE materials, NdAlGe is suggested as promising candidate of R-MCE, which is a novel type of magnetic refrigeration system

Spontaneous capillary breakup of suspended gradient polymer stripes into spatially ordered dot arrays

We describe the experimental study on the spontaneous capillary instability of gradient poly(methyl methacrylate) (PMMA) stripes beneath the continuous polystyrene (PS) film. Upon vapor annealing using a selective solvent only for PMMA, the PMMA stripes were transformed into well-ordered dot-arrays beneath the continuous PS film via capillary force driven rupture. Dimensional features of the PMMA dots strongly did not depend upon the initial width and height of the PMMA microscopic stripes. Repeatedly, such this gradient stripe geometry triggered a competition between the phase correlation of neighboring stripes and the kinetically favorable wavelength, thus leading to the formation of an intriguing, recursive surface sub-patterns