Language as Function or Fashion? Multilingual Identity Formation Through Korean Language Learning

This research examines identity in relation to the Korean language learning experiences of non-Korean and ethnic Korean learners. Based on participant observation and interviews done in Toronto and an international online survey, I use a language-ideological perspective to look at why and how people choose to learn (or not learn) a particular language. Specifically, I analyze how nationalist, functionalist and cosmopolitan language ideologies position learners in various ways and in turn, affect their sense of ethnic, cultural and other forms of identity. I show how these ideologies are interrelated and have different effects on how the identities of non-Koreans and ethnic Koreans are constructed based on their respective statuses as outgroup and ingroup members learning Korean. This research provides a better understanding of the motivations behind heritage and minority language learning, and suggests a less homogeneous conceptualization of heritage language learners

Anti-Tuberculosis Drugs and Adverse Events

Anti-tuberculosis (TB) drugs can cause adverse drug reactions, particularly the older second-line drugs. Early intervention and adequate management of adverse drug reactions are important to prevent complications. Laboratory testing at baseline and during treatment, in addition to clinical monitoring, is protocolized to improve patient and treatment management. This chapter provides an overview of the most frequent and severe adverse effects caused by the first-and second-line drugs used for the treatment of tuberculosis. An approach on how to manage the adverse drugs effects is briefly described.</p

Anti-Tuberculosis Drugs and Adverse Events

Anti-tuberculosis (TB) drugs can cause adverse drug reactions, particularly the older second-line drugs. Early intervention and adequate management of adverse drug reactions are important to prevent complications. Laboratory testing at baseline and during treatment, in addition to clinical monitoring, is protocolized to improve patient and treatment management. This chapter provides an overview of the most frequent and severe adverse effects caused by the first-and second-line drugs used for the treatment of tuberculosis. An approach on how to manage the adverse drugs effects is briefly described.</p

Anti-Tuberculosis Drugs and Adverse Events

Anti-tuberculosis (TB) drugs can cause adverse drug reactions, particularly the older second-line drugs. Early intervention and adequate management of adverse drug reactions are important to prevent complications. Laboratory testing at baseline and during treatment, in addition to clinical monitoring, is protocolized to improve patient and treatment management. This chapter provides an overview of the most frequent and severe adverse effects caused by the first-and second-line drugs used for the treatment of tuberculosis. An approach on how to manage the adverse drugs effects is briefly described.</p

Anti-Tuberculosis Drugs and Adverse Events

Anti-tuberculosis (TB) drugs can cause adverse drug reactions, particularly the older second-line drugs. Early intervention and adequate management of adverse drug reactions are important to prevent complications. Laboratory testing at baseline and during treatment, in addition to clinical monitoring, is protocolized to improve patient and treatment management. This chapter provides an overview of the most frequent and severe adverse effects caused by the first-and second-line drugs used for the treatment of tuberculosis. An approach on how to manage the adverse drugs effects is briefly described.</p

Anti-Tuberculosis Drugs and Adverse Events

Anti-tuberculosis (TB) drugs can cause adverse drug reactions, particularly the older second-line drugs. Early intervention and adequate management of adverse drug reactions are important to prevent complications. Laboratory testing at baseline and during treatment, in addition to clinical monitoring, is protocolized to improve patient and treatment management. This chapter provides an overview of the most frequent and severe adverse effects caused by the first-and second-line drugs used for the treatment of tuberculosis. An approach on how to manage the adverse drugs effects is briefly described.</p

Anti-Tuberculosis Drugs and Adverse Events

Anti-tuberculosis (TB) drugs can cause adverse drug reactions, particularly the older second-line drugs. Early intervention and adequate management of adverse drug reactions are important to prevent complications. Laboratory testing at baseline and during treatment, in addition to clinical monitoring, is protocolized to improve patient and treatment management. This chapter provides an overview of the most frequent and severe adverse effects caused by the first-and second-line drugs used for the treatment of tuberculosis. An approach on how to manage the adverse drugs effects is briefly described.</p

Isospin breaking corrections to low-energy pi-K scattering

We evaluate the matrix elements for the processes pi^0 K^0 -> pi^0 K^0 and pi^- K^+ -> pi^0 K^0 in the presence of isospin breaking terms at leading and next-to-leading order. As a direct application the releveant combination of the S-wave scattering lengths involved in the pion-kaon atom lifetime is determined. We discuss the sensitivity of the results with respect to the input parameters.Comment: 33 pages, plain latex, 2 figure

Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment

Gold nanohexapods represent a novel class of optically tunable nanostructures consisting of an octahedral core and six arms grown on its vertices. By controlling the length of the arms, their localized surface plasmon resonance peaks could be tuned from the visible to the near-infrared region for deep penetration of light into soft tissues. Herein we compare the in vitro and in vivo capabilities of Au nanohexapods as photothermal transducers for theranostic applications by benchmarking against those of Au nanorods and nanocages. While all these Au nanostructures could absorb and convert near-infrared light into heat, Au nanohexapods exhibited the highest cellular uptake and the lowest cytotoxicity in vitro for both the as-prepared and PEGylated nanostructures. In vivo pharmacokinetic studies showed that the PEGylated Au nanohexapods had significant blood circulation and tumor accumulation in a mouse breast cancer model. Following photothermal treatment, substantial heat was produced in situ and the tumor metabolism was greatly reduced for all these Au nanostructures, as determined with ^(18)F-flourodeoxyglucose positron emission tomography/computed tomography (^(18)F-FDG PET/CT). Combined together, we can conclude that Au nanohexapods are promising candidates for cancer theranostics in terms of both photothermal destruction and contrast-enhanced diagnosis

Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer

Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23). We report that these complexes also catalyze H3K23 propionylation in vitro and in vivo. Immunofluorescence microscopy and ATAC-See revealed the association of this modification with active chromatin. Brpf1 deletion obliterates the acylation in mouse embryos and fibroblasts. Moreover, we identify BRPF1 variants in 12 previously unidentified cases of syndromic intellectual disability and demonstrate that these cases and known BRPF1 variants impair H3K23 propionylation. Cardiac anomalies are present in a subset of the cases. H3K23 acylation is also impaired by cancer-derived somatic BRPF1 mutations. Valproate, vorinostat, propionate and butyrate promote H3K23 acylation. These results reveal the dual functionality of BRPF1-KAT6 complexes, shed light on mechanisms underlying related developmental disorders and various cancers, and suggest mutation-based therapy for medical conditions with deficient histone acylation