Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial

Pumpkin seed oil (PSO) has been shown to block the action of 5-alpha reductase and to have antiandrogenic effects on rats. This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of PSO for treatment of hair growth in male patients with mild to moderate androgenetic alopecia (AGA). 76 male patients with AGA received 400 mg of PSO per day or a placebo for 24 weeks. Change over time in scalp hair growth was evaluated by four outcomes: assessment of standardized clinical photographs by a blinded investigator; patient self-assessment scores; scalp hair thickness; and scalp hair counts. Reports of adverse events were collected throughout the study. After 24 weeks of treatment, self-rated improvement score and self-rated satisfaction scores in the PSO-treated group were higher than in the placebo group ( = 0.013, 0.003). The PSOtreated group had more hair after treatment than at baseline, compared to the placebo group ( < 0.001). Mean hair count increases of 40% were observed in PSO-treated men at 24 weeks, whereas increases of 10% were observed in placebo-treated men ( < 0.001). Adverse effects were not different in the two groups

A single-inductor switching DC-DC converter with five outputs and ordered power-distributive control

An integrated five-output single-inductor multiple-output dc-dc converter with ordered power-distributive control (OPDC) in a 0.5 mu m Bi-CMOS process is presented. The converter has four main positive boost outputs programmable from +5 V to +12 V and one dependent negative output ranged from -12 V to -5 V. A maximum efficiency of 80.8% is achieved at a total output power of 450 mW, with a switching frequency of 700 kHz. The performance of the converter as a commercial product is successfully verified with a new control method and proposed circuits, including a full-waveform inductor-current sensing circuit, a variation-free frequency generator, and an in-rush-current-free soft-start method. With simplicity, flexibility, and reliability, the design enables shorter time-to-market in future extensions with more outputs and different operation requirements