The evolution of public health genomics: Exploring its past, present, and future

Public health genomics has evolved to responsibly integrate advancements in genomics into the fields of personalized medicine and public health. Appropriate, effective and sustainable integration of genomics into healthcare requires an organized approach. This paper outlines the history that led to the emergence of public health genomics as a distinguishable field. In addition, a range of activities are described that illustrate how genomics can be incorporated into public health practice. Finally, it presents the evolution of public health genomics into the new era of “precision public health.

Solution and Asymptotic Behavior for a Nonlocal Coupled System of Reaction-Diffusion

This paper concerns with existence, uniqueness and asymptotic behavior of the solutions for a nonlocal coupled system of reaction-diffusion. We prove the existence and uniqueness of weak solutions by the Faedo-Galerkin method and exponential decay of solutions by the classic energy method. We improve the results obtained by Chipot-Lovato and Menezes for coupled systems. A numerical scheme is presented

Stability and Complexity of Minimising Probabilistic Automata

We consider the state-minimisation problem for weighted and probabilistic automata. We provide a numerically stable polynomial-time minimisation algorithm for weighted automata, with guaranteed bounds on the numerical error when run with floating-point arithmetic. Our algorithm can also be used for "lossy" minimisation with bounded error. We show an application in image compression. In the second part of the paper we study the complexity of the minimisation problem for probabilistic automata. We prove that the problem is NP-hard and in PSPACE, improving a recent EXPTIME-result.Comment: This is the full version of an ICALP'14 pape

Charge and mass effects on the evaporation of higher-dimensional rotating black holes

To study the dynamics of discharge of a brane black hole in TeV gravity scenarios, we obtain the approximate electromagnetic field due to the charged black hole, by solving Maxwell's equations perturbatively on the brane. In addition, arguments are given for brane metric corrections due to backreaction. We couple brane scalar and brane fermion fields with non-zero mass and charge to the background, and study the Hawking radiation process using well known low energy approximations as well as a WKB approximation in the high energy limit. We argue that contrary to common claims, the initial evaporation is not dominated by fast Schwinger discharge.Comment: Published version. Minor typos corrected. 29 pages, 5 figure

Polaronic Signatures in Mid-Infrared Spectra: Prediction for LaMnO3 and CaMnO3

Hole-doped LaMnO3 and electron-doped CaMnO3 form self-trapped electronic states. The spectra of these states have been calculated using a two orbital (Mn eg Jahn-Teller) model, from which the non-adiabatic optical conductivity spectra are obtained. In both cases the optical spectrum contains weight in the gap region, whose observation will indicate the self-trapped nature of the carrier states. The predicted spectra are proportional to the concentration of the doped carriers in the dilute regime, with coefficients calculated with no further model parameters.Comment: 6 pages with 3 figures imbedde

D∗DπD^*D\pi and B∗BπB^*B\pi couplings in QCD

We calculate the $D^*D\pi$ and $B^*B\pi$ couplings using QCD sum rules on the light-cone. In this approach, the large-distance dynamics is incorporated in a set of pion wave functions. We take into account two-particle and three-particle wave functions of twist 2, 3 and 4. The resulting values of the coupling constants are $g_{D^*D\pi}= 12.5\pm 1$ and $g_{B^*B\pi}= 29\pm 3$. From this we predict the partial width \Gamma (D^{*+} \ra D^0 \pi^+ )=32 \pm 5~ keV . We also discuss the soft-pion limit of the sum rules which is equivalent to the external axial field approach employed in earlier calculations. Furthermore, using $g_{B^*B\pi}$ and $g_{D^*D\pi}$ the pole dominance model for the B \ra \pi and D\ra \pi semileptonic form factors is compared with the direct calculation of these form factors in the same framework of light-cone sum rules.Comment: 27 pages (LATEX) +3 figures enclosed as .uu file MPI-PhT/94-62 , CEBAF-TH-94-22, LMU 15/9

Greybody Factors for Rotating Black Holes on Codimension-2 Branes

We study the absorption probability and Hawking radiation of the scalar field in the rotating black holes on codimension-2 branes. We find that finite brane tension modifies the standard results in Hawking radiation if compared with the case when brane tension is completely negligible. We observe that the rotation of the black hole brings richer physics. Nonzero angular momentum triggers the super-radiance which becomes stronger when the angular momentum increases. We also find that rotations along different angles influence the result in absorption probability and Hawking radiation. Compared with the black hole rotating orthogonal to the brane, in the background that black hole spins on the brane, its angular momentum brings less super-radiance effect and the brane tension increases the range of frequency to accommodate super-radiance. These information can help us know more about the rotating codimension-2 black holes.Comment: 16 pages, 7 figures, minor modification, accepted for publication in JHE

Photon polarization in radiative B decays

We study decay distributions in B -> K pi pi gamma, combining contributions from several overlapping resonances in a K pi pi mass range near 1400 MeV, (1^+) K_1(1400), (2^+) K^*_2(1430) and (1^-) K^*(1410). A method is proposed for using these distributions to determine a photon polarization parameter in the effective radiative weak Hamiltonian. This parameter is measured through an up-down asymmetry of the photon direction relative to the K pi pi decay plane. We calculate a dominant up-down asymmetry of 0.33 +- 0.05 from the K1(1400) resonance, which can be measured with about 10^8 B B-bar pairs, thus providing a new test for the Standard Model and a probe for some of its extensions.Comment: 22 pages, 3 figures, version to appear in Phys. Rev.

SPIDER: Probing the Early Universe with a Suborbital Polarimeter

We evaluate the ability of SPIDER, a balloon-borne polarimeter, to detect a divergence-free polarization pattern ("B-modes") in the Cosmic Microwave Background (CMB). In the inflationary scenario, the amplitude of this signal is proportional to that of the primordial scalar perturbations through the tensor-to-scalar ratio r. We show that the expected level of systematic error in the SPIDER instrument is significantly below the amplitude of an interesting cosmological signal with r=0.03. We present a scanning strategy that enables us to minimize uncertainty in the reconstruction of the Stokes parameters used to characterize the CMB, while accessing a relatively wide range of angular scales. Evaluating the amplitude of the polarized Galactic emission in the SPIDER field, we conclude that the polarized emission from interstellar dust is as bright or brighter than the cosmological signal at all SPIDER frequencies (90 GHz, 150 GHz, and 280 GHz), a situation similar to that found in the "Southern Hole." We show that two ~20-day flights of the SPIDER instrument can constrain the amplitude of the B-mode signal to r<0.03 (99% CL) even when foreground contamination is taken into account. In the absence of foregrounds, the same limit can be reached after one 20-day flight.Comment: 29 pages, 8 figures, 4 tables; v2: matches published version, flight schedule updated, two typos fixed in Table 2, references and minor clarifications added, results unchange