Magnetic Levitation as a Tool for Separation: Separating Cocrystals from Crystalline Phases of Individual Compounds

In this contribution, we extend the phase separation abilities of magnetic levitation (MagLev), applying it to cocrystal systems. Most of these systems show incongruent solubility in solution. Crystallization from an equimolar mixture often leads to the crystallization of both cocrystal and coformer (one of the individual cocrystal formers). Using carbamazepine/salicylic acid and carbamazepine/camphoric acid systems, we demonstrated that MagLev is an efficient and straightforward tool for phase separation in these systems

Simultaneous Chiral Resolution of Two Racemic Compounds by Preferential Cocrystallization

We tap into an unexplored area of preferential crystallization, being the first to develop simultaneous chiral resolution of two racemic compounds by preferential cocrystallization.We highlight how the two racemic compounds RS-mandelic acid (MAN) and RS-etiracetam (ETI) can be combined together as enantiospecific R-MAN:R-ETI and S-Man:S-ETI cocrystals forming a stable conglomerate system and subsequently develop a cyclic preferential crystallization allowing to simultaneous resolve both compounds. The developed process leads to excellent enantiopurity both for etiracetam (ee>98%) and mandelic acid (ee~95%) enantiomers </div