2 research outputs found
Magnetic Levitation as a Tool for Separation: Separating Cocrystals from Crystalline Phases of Individual Compounds
In
this contribution, we extend the phase separation abilities
of magnetic levitation (MagLev), applying it to cocrystal systems.
Most of these systems show incongruent solubility in solution. Crystallization
from an equimolar mixture often leads to the crystallization of both
cocrystal and coformer (one of the individual cocrystal formers).
Using carbamazepine/salicylic acid and carbamazepine/camphoric acid
systems, we demonstrated that MagLev is an efficient and straightforward
tool for phase separation in these systems
Simultaneous Chiral Resolution of Two Racemic Compounds by Preferential Cocrystallization
We tap into an unexplored area of preferential crystallization, being the first to develop
simultaneous chiral resolution of two racemic compounds by preferential cocrystallization.We highlight how the two racemic compounds RS-mandelic acid (MAN) and RS-etiracetam
(ETI) can be combined together as enantiospecific R-MAN:R-ETI and S-Man:S-ETI cocrystals
forming a stable conglomerate system and subsequently develop a cyclic preferential
crystallization allowing to simultaneous resolve both compounds. The developed process
leads to excellent enantiopurity both for etiracetam (ee>98%) and mandelic acid (ee~95%)
enantiomers
</div