Association of maternal BMI with vitamin B12 and folate concentrations (tertiles).

<p>Bars represent geometric mean BMI for each group.</p

Multiple regression analysis to demonstrate the relationships between BMI and potential confounding variables on serum folate.

<p>* Denotes variable transformed using natural logs (allowing β coefficients to be interpreted in terms of percentage change)</p><p>Partial R is the adjusted Pearson correlation coefficient.</p

Univariate associations between B12, folate and BMI with potential confounders (lifestyle/demographic, pregnancy related and haemodilutional factors) in 995 pregnant women.

<p>* denotes log transformed data</p><p>Pearson correlation coefficients (r) presented for continuous variables</p

Multiple regression analysis to demonstrate the relationships between BMI and potential confounding variables on serum vitamin B12.

<p>*Denotes variable transformed using natural logs (allowing β coefficients to be interpreted in terms of percentage change)</p><p>Partial R is the adjusted correlation coefficient.</p

Baseline characteristics of study cohort (n = 995) at 28 weeks gestation.

<p>Data presented as mean +/- SD (or *geometric mean (SD range) for log transformed data). Discrete variables presented as (%) for characteristic.</p><p>AST = Aspartate Aminotransferase.</p><p>Baseline characteristics of study cohort (n = 995) at 28 weeks gestation.</p

Concentrations of markers of vitamin B12 and folate status and change compared to the placebo.

<p>¹ Interquartile range.</p><p>² Mean difference change in concentration from baseline.</p><p>³ 95% Confidence interval.</p><p>Concentrations of markers of vitamin B12 and folate status and change compared to the placebo.</p

Plasma concentrations of vitamin B-12, 1-C metabolites and amino acids by vitamin B-12 concentration. Observations were stratified based upon the plasma vitamin B-12 levels more or less than 150 pmol/L (both visit1 and visit2 together).

<p>Plasma concentrations of vitamin B-12, 1-C metabolites and amino acids by vitamin B-12 concentration. Observations were stratified based upon the plasma vitamin B-12 levels more or less than 150 pmol/L (both visit1 and visit2 together).</p

[C²H₃] enrichment (moles percent excess) of plasma methionine and estimates of remethylation (Rm) of homocysteine folling tracer labelled methionine load in relation to plasma B-12 levels.

<p>[C²H₃] enrichment (moles percent excess) of plasma methionine and estimates of remethylation (Rm) of homocysteine folling tracer labelled methionine load in relation to plasma B-12 levels.</p

ORs¹ (95% CIs)² for being in the lower quartile of ASQ-3 total in the intervention group compared with placebo in subgroups.³

<p>*p<0.05.</p><p>¹Odds Ratio.</p><p>²95% Confidence interval.</p><p>³Adjusted for sex, age, breastfeeding status, stunting and Mother`s encouragement of developmental advances (dichotomus).</p><p>ORs<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0129915#t005fn002" target="_blank">¹</a> (95% CIs)<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0129915#t005fn003" target="_blank">²</a> for being in the lower quartile of ASQ-3 total in the intervention group compared with placebo in subgroups.<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0129915#t005fn004" target="_blank">³</a></p

Baseline characteristics of the 422 children age 6–30 months.

<p>¹ Mean±SD all such values.</p><p>² Missing information from 1 child.</p><p>³ Indian Rupees in median (Interquartile range).</p><p>⁴Childcare centre.</p><p>Baseline characteristics of the 422 children age 6–30 months.</p