PReS-FINAL-2041: Macrophage activation syndrome in the children with systemic juvenile idiopathic arthritis during the course of tocilizumab

Background Trauma exposure and posttraumatic stress disorder (PTSD) are common among individuals with a mental disorder, but symptoms often go undetected and untreated. Methods The aim of this study was to determine the prevalence of PTSD among a large sample of adults with psychiatric diagnoses and to establish factors associated with symptoms going undetected. Participants were 1,946 adults recruited by the National Centre for Mental Health. Structured interviews and validated self-report questionnaires were used to ascertain clinical and demographic information for analysis. Results The prevalence of participants screening positive for PTSD that had not been detected by clinical services was 13.9% [12.4–15.5%, 95% confidence interval]). Factors associated with undetected PTSD were female gender, younger age of first contact with psychiatric services, and lower household income. Especially, poor rates of detection were observed after traumatic events, such as child abuse and sexual assault. Conclusions Our findings demonstrate the need for routine assessment of trauma histories and symptoms of PTSD among individuals with anymental disorder

Influence of Tocolytic Therapy with Hexoprenaline on Heart Rate Variability, Lipid Spectrum and Glycemic Level in Obese Pregnant Women

Background. Obesity is associated with the risk of spontaneous preterm birth. Hexoprenaline is the effective and most widely used tocolytic agent, possessing however a significant number of side effects. The effect of hexoprenaline tocolysis on heart rate variability, lipid spectrum and glycaemia level in obese pregnant women remain unexplored.Aim of the research. To study the effect of tocolytic therapy with hexoprenaline on heart rate variability, lipid spectrum and glycemic level in obese pregnant women.Materials and methods. The study included two groups of pregnant women with threatened preterm labor who received tocolysis with hexoprenaline. One group consisted of 68 obese patients, the other – 72 non-obese pregnant women (control group). Patients underwent Holter monitoring. Fasting serum glucose and lipids spectrum were measured before starting tocolytic therapy and after 24 hours of tocolysis.Results. In obese pregnant women with hexoprenaline infusion, the heart rate, the 24-hours number of supraventricular extrasystoles and ventricular extrasystoles during the day are significantly higher. Frequency domain parameters, very low frequency during the day, low frequency at night and 24-hours high frequency were significantly decreased than in control group. After a day of tocolysis in obese pregnant women, the level of total cholesterol, low density lipoproteins, triglycerides, and glucose significantly increases when compared with the results before therapy. For patients in the control group treated with hexoprenaline, only the concentration of high-density lipoproteins is increased.Conclusion. Obesity in pregnant women receiving hexoprenaline tocolysis is associated with low heart rate variability and an increase in the number of cardiac arrhythmias, as well as lipid disorders and an increase in glucose level

Magnetic Phase Separation and Magnetic Moment Alignment in Ordered Alloys FE 65

The structure and the magnetic state of ordered Fe65Al35-xMx (Mx = Ga, B; x = 0; 5 at.%) alloys are investigated using X-ray diffraction, Mössbauer spectroscopy, and magnetic measurements. The behavior of the magnetic characteristics and Mössbauer spectra of the binary alloy Fe65Al35 and the ternary alloy with gallium addition Fe65Al30Ga5 is explained in terms of the phase separation into two magnetic phases: a ferromagnetic one and a spin density wave. It is shown that the addition of boron to the initial binary alloy Fe65Al35 results in the ferromagnetic behavior of the ternary alloy

The development of a new bread wheat genotype carrying two loci for endosperm softness

The technological purpose of grain and flour wheat is largely determined by the grains endosperm structure. Its variability among wheat varieties depends mainly on the multiple allelism for a single Ha locus on chromosome 5D leading to a continuous variation of the trait. The grain endosperm can vary from hard and vitreous suitable for yeast baking to soft and floury favorable for confectionery and technical purposes. Furthermore, these traits, especially vitreousness, are strongly influenced by the growth conditions. Earlier, the Ha-Sp locus was introgessed into chromosome 5A of the bread wheat line 84/98w from Aegilops speltoides Tausch., which reduces endosperm hardness and vitreousness, like the dominant allele of the Ha locus. This paper is the first to describe the obtaining and testing of the supersoft lines combining in their genotype the homoeoallelic loci Ha-Sp of the line 84/98w and Ha of the soft grain cultivar Chinese Spring. The lines were isolated from 6–8 generations of self-pollinated F2 hybrids. They consistently exhibit a greater grain softness than the parental forms under both greenhouse and field conditions. These lines can be used in the breeding of wheat cultivars, the flour of which will not require chemical baking powder in the confectionery industry. It is also possible to use them for technical purposes for the production of bioethanol. In addition, these lines may serve as a genetic model for the study of the functional activity of homoeoallelic genes in the complex polyploid genomes of plants

Experience of the successful treatment with canakinumab of a patient with NLPC4-associated autoinflammatory syndrome with enterocolitis

The article shows the observation of rare NLPC4-associated autoinflammatory syndrome with enterocolitis and familial cold urticaria. Diagnosis is confirmed molecularly-genetically: previously not described mutation c.928C>T in the heterozygous state in NLRC4 gene is discovered by a method of the new generation sequencing. The use of a monoclonal antibody to the interleukin 1 canakinumab provided complete relief of fever and skin and intestinal symptoms in just 1 week of treatment. Later the signs of inflammation have disappeared completely; the patient’s quality of life improved and life-threatening complications were prevented. The above example demonstrates the high clinical efficacy of canakinumab in the patient with NLRC4-associated autoinflammatory syndrome and suggests promising therapeutic use of interleukin 1 blockers in such patients. There were no adverse events during canakinumab therapy

High Efficiency of Kanakinumabum for a Patient with a Late Diagnosed Chronic Infantile Neurological Cutaneous Articular Syndrome (CINCA)

The article presents the monitoring of a severe course of CINCA/NOMID syndrome diagnosed at late stages. The use of monoclonal antibodies to IL 1 — kanakinumabum — in a patient with chronic neurological cutaneous and articular syndrome was successful: fever, cutaneous and pain syndromes were completely stopped, joint contractures decreased after one week of therapy. Laboratory parameters of the child’s disease activity (ESR and CRP) became normal after 8 weeks of treatment. Movements in the affected joints recovered completely after 24 weeks; the audiologist noted an improvement in hearing. The above clinical example demonstrates the high efficiency of kanakinumabum for a patient with chronic neurological cutaneous and articular syndrome, and shows the perspective of therapeutic application of IL 1 blocker for patients with CINCA syndrome including advanced stages of the disease. No adverse effects were noted during kanakinumabum therapy

РЕКОНСТРУКЦИЯ ПИТАЮЩИХ ПРОВИНЦИЙ МОСКОВСКОГО БАССЕЙНА В ПЕРМСКО-ТРИАСОВОЕ ВРЕМЯ ПО ДАННЫМ U-Pb LA-ICP-MS ДАТИРОВАНИЯ И РАМАНОВСКОЙ СПЕКТРОСКОПИИ ОБЛОМОЧНОГО ЦИРКОНА

We present the first systematic results of U-Pb LA-ICP-MS dating of detrital zircons from 12 samples representing different stratigraphic levels of 5 sections of the Permian-Triassic rocks, located within the eastern part of the Moscow basin (syneclise) – Zhukov ravine, Astashikha, Nedubrovo, Balebikha and Klykovo. It is shown that the accumulation of the Upper Permian and Lower Triassic terrigenous complexes occurred under the influence of competing sources with two contrasting provenance signals with Neoproterozoic (Vendian)-Paleozoic and Paleo-Mesoproterozoic ages. The identified provenance signal patterns were used to detail the correlation and stratigraphic subdivision of the Permian-Triassic terrigenous complex of the Moscow basin. Raman spectroscopy of detrital zircon, first applied to the Permian-Triassic rocks of the East European platform, made it possible to identify sedimentary complexes of a relatively older terrigenous basin as a separate source of zircons, which experienced superimposed thermal impact in the VendianCambrian time (~500–600 Ma).Приведены первые систематические результаты U-Pb LA-ICP-MS датирования зерен обломочного циркона из 12 проб, представляющих разные стратиграфические уровни пяти разрезов пород пограничного пермско-триасового возраста, расположенных в пределах восточного борта Московской синеклизы, – Жуков овраг, Асташиха, Недуброво, Балебиха и Клыково. Показано, что накопление терригенных комплексов верхней перми и нижнего триаса происходило под влиянием конкурирующих источников сноса с двумя контрастными провенанс-сигналами – с венд-палеозойскими и палеомезопротерозойскими возрастными характеристиками. Установленные закономерности использованы для уточнения схем корреляции и стратиграфического расчленения пермско-триасового терригенного комплекса Русской плиты. Метод рамановской спектроскопии обломочного циркона, впервые примененный для пермско-триасовых пород Русской плиты, позволил идентифицировать в качестве отдельного источника сноса осадочные комплексы относительно более древнего терригенного бассейна, испытавшего наложенное термальное воздействие в венд-кембрийское время около 500–600 млн лет назад