Medical Marijuana-Induced Tacrolimus Toxicity.

As both recreational and therapeutic marijuana use increases in the US, more attention is being paid to its direct medical and psychoactive effects. One crucial dimension is the potential for marijuana or marijuana-derived therapies to interact with other prescribed medications. Tacrolimus is an immunosuppressant medication prescribed to prevent rejection in patients receiving solid organ and bone marrow transplants. Clinically, it is characterized by a narrow therapeutic index and multiple drug-drug interactions. Constituents in marijuana are known to inhibit cytochrome P-450 3A, which is normally responsible for metabolizing tacrolimus, leading to the potential for a dangerous interaction. Though this phenomenon has been described previously in a stem cell transplant patient, we present the case of medical marijuana induced tacrolimus toxicity in a patient who recently received an orthotopic liver transplant

Predicting the Effects of Ex-Felon Enfranchisement on the 2020 Presidential Election in Florida

Jones, BryanGovernmen

The Vowelindrome

I have coined a new term in order to point out a phenomenon in the English language: the vowelindrome. A vowelindrome is a series of palindromes which result from the placement of a single letter immediately before and after each of the five vowels. After 26 trials and 24 errors, I have determined that there are only two vowelindromes, corresponding to the letters P and T

Optimizing and Benchmarking Returnable Container Processes within an Automotive Distribution System

An analysis of Reusable Packaging in automobile manufacturing facilities, as well as a comparison to other industries, shows that returnable container systems are not being fully utilized. In this study, methods to return and track packaging materials for reuse are examined. Issues identified through surveys and interviews are summarized, and a recommendation to more fully utilize systems currently in place is proposed. An evaluation based on utilizing the current system will enable us to assign a cost to current operations, and may support an investment in improved systems and technologies. Most of the companies surveyed gauge functionality based on whether or not there are shortages severe enough to stop production. This fact is determined through Gap Analysis, Benchmarking, and Case Studies. A process by which to track losses, costs, turnaround time, etc. of container return systems is currently not seen as a critical function of production, consequently no justification exists for investing in upgrading these systems. A Closed Loop Packaging System refers to a well-defined circuit of shipping and delivery points. This closed circuit is essential to ensure that containers flowing through the system do not get lost (www.returnables.com). Locating and rerouting stray or replacing lost containers can be a significant, unplanned cost related to packaging returns. The automotive industry estimates a minimum of seven percent (7.00%) of automotive company budgets are spent replacing non-disposable containers and racks (page 5 - AIAG 2008), therefore improvements to this part of the process could result in significant cost savings, and ultimately affect a company\u27s bottom line

THE INFLUENCE OF AN EARLY CHILDHOOD ENDORSEMENT PROGRAM ON EARLY CHILDHOOD LEADERSHIP COMPETENCIES

The call to improve high-quality educational opportunities for children ages birth – eight has received increased attention and federal and local funding opportunities have expanded to provide additional early childhood classrooms and to implement family engagement practices. Unfortunately, systems of support for principals aimed at increasing knowledge and skills necessary to lead an aligned Preschool – third-grade system within an elementary school remain relatively sparse. The purpose of this study is to examine the alignment between an early childhood endorsement program and early childhood leadership competencies. This study will examine the perceptions of school leaders participating in an early childhood endorsement program regarding endorsement program alignment with leadership competencies and practices. A document analysis will be completed to identify the levels of alignment between early childhood endorsement course content and early childhood leadership competencies. In addition, endorsement program participants will be asked to complete a self-reflection addressing specific strategies, related to the early childhood leadership competencies, to determine if the competencies were addressed directly, indirectly, or not addressed throughout the endorsement program. Finally, two groups of leaders in early childhood, PreK-3rd grade, settings will be asked to complete a self-assessment rating demonstrating how evident specific early childhood leadership practices are in the practices they perform as a school leader. The data collected will help determine if participation in early childhood endorsement programs can be used to develop early childhood leadership skills of administrators in early childhood settings

On Teaching Palindromes

Webster\u27s Third New International Dictionary defines palindrome as a word, verse, or sentence that reads the same backward as forward . As is often the case with limericks, sonnets, and other highly-structured but nowadays seldom-pursued literary creations, the few frequently-anthologized examples have come to be the only examples we know. This is certainly the case with the palindrome

Metamorphic Expressions in Metal

The actual essence of the creator’s objective was to able to visualize beauty of nature through the use of metal, may it be expressing something of infinity or for only a season, perhaps bold or minute. Growth and decay, both having beauty in their own right, and both having a time of visual existence, suggested ideas to the sculptor. The flexibility of welding rod best expresses the beauty of nature for the sculptor rather than sheet steel because he was able to obtain a growth-like quality of nature, not only of plant life, but of growth and decay of nature herself. The sculptor also found that accidents which occur in some mediums were not experienced in the use of metal; thus he believes that the experiences which he has had were pure experiences. Unlike water color, ceramic glazes, or some graphic processes which can produce effects contrary to the creator’s ideas, welding with steel produces only that which the creator intends. “Varied Passage”, the third sculpture which the sculptor developed seemed to create more difficulty than any other sculptural form. Perhaps the problem arose because of the sculptor’s attempt to express the same theme, that of recline, in another form. Not until “Varied Passage” was completed did it become evident that a previous piece, “Formation”, more clearly communicated the sculptor’s feelings concerning this theme. Through intense study of the materials used by the sculptor, he was better able to use ideas, thoughts, and personal emotions which were suggested to him by previous works he had done. Such suggestions as textures, line, and space helped provide ideas for the different pieces created for this study. The development of expressions of nature, may it be something concerning growth or decay, or both, is something which could be approached in many different ways. The sculptor believes that creating a sculpture using some interpretation of a facet of nature is best done through the use of a material such as steel which offers the variation of form and tensile strength associated with nature