65 research outputs found
A case of extravascular hemolysis with Tkâactivation
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108281/1/ccr380.pd
ABOâassociated antibodyâmediated rejection following A2BâtoâB renal transplantation and successful treatment with therapeutic plasma exchange
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149287/1/trf15201_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149287/2/trf15201.pd
A case of cryocrystalglobulinemia
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/133638/1/trf13528_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133638/2/trf13528.pd
Performance and safety of femoral central venous catheters in pediatric autologous peripheral blood stem cell collection
IntroductionAutologous peripheral blood hematopoietic progenitor cell collection (AâHPCC) in children typically requires placement of a central venous catheter (CVC) for venous access. There is scant published data regarding the performance and safety of femoral CVCs in pediatric AâHPCC.MethodsSevenâyear, retrospective study of AâHPCC in pediatric patients collected between 2009 and January 2017. Inclusion criteria were an ageââ€â21 years and AâHPCC using a femoral CVC for venous access. Femoral CVC performance was examined by CD34 collection rate, inlet rate, collection efficiency (MNCâFE, CD34âFE), bleeding, flowârelated adverse events (AE), CVC removal, and product sterility testing. Statistical analysis and graphing were performed with commercial software.ResultsA total of 75/119 (63%) pediatric patients (median age 3 years) met study criteria. Only 16% of children required a CVC forââ„â3 days. The CD34 collect rate and CD34âFE was stable over time whereas MNCâFE decreased after day 4 in 80% of patients. CD34âFE and MNCâFE showed interâ and intraâpatient variability over time and appeared sensitive to plerixafor administration. Femoral CVC showed fewer flowârelated AE compared to thoracic CVC, especially in pediatric patients (6.7% vs. 37%, Pâ=â0.0005; ORâ=â0.12 (95%CI: 0.03â0.45). CVC removal was uneventful in 73/75 (97%) patients with hemostasis achieved after 20â30 min of pressure. In a 10âyear period, there were no instances of product contamination associated with femoral CVC colonization.ConclusionFemoral CVC are safe and effective for AâHPCC in young pediatric patients. Femoral CVC performance was maintained over several days with few flowârelated alarms when compared to thoracic CVCs.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139987/1/jca21548.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139987/2/jca21548_am.pd
Procedureârelated complications and adverse events associated with pediatric autologous peripheral blood stem cell collection
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135698/1/jca21465.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135698/2/jca21465_am.pd
Efficacy of therapeutic plasma exchange on angiotensin II typeâ1 receptor antibodies on two kidney transplant recipients
BackgroundAngiotensin II typeâ1 receptor antibody (AT1RAb) has been reported to cause antibody mediated rejection (AMR) in kidney transplant recipients possibly by contraction of renal arteries. We here report 2 kidney transplant recipients with elevated AT1RAbs and negative HLA donor specific antibodies (DSA) and antiâmajor histocompatibility complex class I chainârelated gene A (MICA) Abs who received therapeutic plasma exchange (TPE) treatment followed by IVIG.Case 1Thirtyâeightâyearâold patient received second kidney transplant for end stage renal disease (ESRD) with chronic rejection. Three years postâtransplant, she developed AMR with AT1RAb level >40âU/mL. She received 5 TPE and AT1RAb decreased by 20%, and biopsy showed improvement of AMR. She received another 3 TPE and AT1RAb decreased by 60%. Her creatinine (Cr) was stabilized at around 1.4 mg/dL.Case 2Twentyâfourâyearâold patient received kidney transplant for ESRD with unclear etiology. Two weeks postâtransplant, her Cr rose with AT1RAb level at 18âU/mL and biopsy showed possible AMR. She received 6 TPE treatments and AT1RAb decreased by 55% and biopsy showed improvement of AMR. She received weekly TPE for subsequently rising AT1RAb but TPE was discontinued because of unsuccessful decrease of AT1RAb. Her Cr was stabilized at around 1.7 mL/dL.ConclusionWe reported 2 patients who received TPE treatments to decrease AT1RAbs. A course of TPE treatment successfully decreased AT1RAb. Histological improvement was observed quickly and Cr was also stabilized following the TPE treatment. Further study is necessary to determine the optimal use of TPE in renal transplant recipients with AT1RAbs.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146572/1/jca21657.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146572/2/jca21657_am.pd
Efficacy of plasmapheresis on donorâspecific antibody reduction by HLA specificity in postâkidney transplant recipients
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111098/1/trf12923.pd
Effects of the search technique on the measurement of the change in quality of randomized controlled trials over time in the field of brain injury
BACKGROUND: To determine if the search technique that is used to sample randomized controlled trial (RCT) manuscripts from a field of medical science can influence the measurement of the change in quality over time in that field. METHODS: RCT manuscripts in the field of brain injury were identified using two readily-available search techniques: (1) a PubMed MEDLINE search, and (2) the Cochrane Injuries Group (CIG) trials registry. Seven criteria of quality were assessed in each manuscript and related to the year-of-publication of the RCT manuscripts by regression analysis. RESULTS: No change in the frequency of reporting of any individual quality criterion was found in the sample of RCT manuscripts identified by the PubMed MEDLINE search. In the RCT manuscripts of the CIG trials registry, three of the seven criteria showed significant or near-significant increases over time. CONCLUSIONS: We demonstrated that measuring the change in quality over time of a sample of RCT manuscripts from the field of brain injury can be greatly affected by the search technique. This poorly recognized factor may make measurements of the change in RCT quality over time within a given field of medical science unreliable
Associations among the plasma amino acid profile, obesity, and glucose metabolism in Japanese adults with normal glucose tolerance
- âŠ