eLearning

The e-Learning website will be on technology course concepts and will help the users learn the technical information to improve their knowledge. With that knowledge and information, they can implement the concepts in real-time to develop the applications and websites by using different technologies. This e-Learning website on technology will reduce users’ study time concerning finding different technological concepts in one platform. Nowadays, reading a complete book on one technology is taking more time than reading the same book concepts from the e-learning platform. This application will be a new application and provide the technical information concept-wise. This application will be released on December 1st, 2021, and no other future releases are planned

NANOSCALE FUNCTIONALIZATION AND CHARACTERIZATION OF SURFACES WITH HYDROGEL PATTERNS AND BIOMOLECULES

The advent of numerous tools, ease of techniques, and concepts related to nanotechnology, in combination with functionalization via simple chemistry has made gold important for various biomedical applications. In this dissertation, the development and characterization of planar gold surfaces with responsive hydrogel patterns for rapid point of care sensing and the functionalization of gold nanoparticles for drug delivery are highlighted. Biomedical micro- and nanoscale devices that are spatially functionalized with intelligent hydrogels are typically fabricated using conventional UV-lithography. Herein, precise 3-D hydrogel patterns made up of temperature responsive crosslinked poly(N-isopropylacrylamide) over gold were synthesized. The XY control of the hydrogel was achieved using microcontact printing, while thickness control was achieved using atom transfer radical polymerization (ATRP). Atomic force microscopy analysis showed that to the ATRP reaction time governed the pattern growth. The temperature dependent swelling ratio was tailored by tuning the mesh size of the hydrogel. While nanopatterns exhibited a broad lower critical solution temperature (LCST) transition, surface roughness showed a sharp LCST transition. Quartz crystal microbalance with dissipation showed rapid response behavior of the thin films, which makes them applicable as functional components in biomedical devices. The easy synthesis, relative biocompatibility, inertness, and easy functionalization of gold nanoparticles (GNPs) have made them useful for various biomedical applications. Although ATRP can be successfully carried out over GNPs, the yield of stable solution based GNPs for biomedical applications prove to be low. As an alternative approach, a novel method of ISOlating, FUnctionalizing, and REleasing nanoparticles (ISOFURE) was proposed. Biodegradable poly(β-amino ester) hydrogels were used to synthesize ISOFURE-GNP composites. ATRP was performed inside the composite, and the final hydrogel coated GNPs were released via matrix degradation. Response analysis confirmed that the ISOFURE method led to the increased stability and yield of the hydrogel coated ISOFURE-GNPs. The ISOFURE protocol was also utilized in functionalizing GNPs with enzyme catalase in the absence of a stabilizing reagent. Biotin-streptavidin affinity was used as the bioconjugation method. Activity analysis of the conjugated enzyme showed that the ISOFURE-GNPs showed enhanced biomolecular loading relative to solution based stabilizing reagent passivated GNPs

Telemedicine and its Utilization in the Management of Chronic Heart Failure Patients

Introduction: Telemedicine is well developed and very useful for heart failure patients in emergencies. Many cases of heart failures are due to inability of reaching the physicians on time and failure of assessing the patient disease condition at earlier stage. Methodology: The methodology for this study was a literature review. Electronic databases used included EBSCO Host, Google Scholar, Academic Search Premier, PubMed, ProQuest, and Marshall Digital Scholar. A total of 32 sources were referenced. Results: This literature review examined several studies and research articles on the significance of Telemedicine in the treatment of chronic heart failure patients with what forms of telemedicine technology was utilized in the treatment processes. In addition, to the benefits, potential outcomes and utilization rate of telemedicine technologies in the care coordination process. Discussion: Significance, utilization and effectiveness of Telemedicine in the treatment of chronic heart failure patients is discussed as an effective technology in the care delivery process with benefits of decreased re-hospitalization and mortality rates, increased patient satisfaction, effective care monitoring, decreased errors and better care coordination are further discussed. Conclusion: Evidence suggests that the utilization of Telemedicine in the care process has potential benefits, yet care providers still want the emergence of new technologies and strategies to better improve the care delivery processes for the patients

STUDY OF ANTIMICROBIAL, ANALGESIC AND ANTICONVULSANT ACTIVITY OF NOVEL ISATIN DERIVATIVES

Isatin is an endogenous compound and possess a wide variety of biological activities. In the present investigation, a different isatin derivatives suchas novel isatin 3-[N-(4-substituted)-hydrazinyl-3-oxo prop 1-en-2yl) benzamides and their antimicrobial, analgesic and anticonvulsant activity wasevaluated in different animal models. Antimicrobial activity by cup plate agar diffusion method. The analgesic activity was measured by Eddy's hotplate method, and reaction time was recorded when the animals licked their for and hind paws and jumped at before 0 hr, 0.5 hr, 1 hr and 2 hrsafter administration of test drugs. 4-aminopyridine chemical induction method was employed for anticonvulsant activity. All the compounds werescreened, among the screened compounds some compounds showed antimicrobial, analgesic and anticonvulsant activity with dose-dependent effectwhen compared with the control group.Keywords: Isatin, Antibacterial, Antifungal, Analgesic, Anticonvulsant activity

A Recovery Scheme for Cluster Federations Using Sender-based Message Logging

A cluster federation is a union of clusters and is heterogeneous. Each cluster contains a certain number of processes. An application running in such a computing environment is divided into communicating modules so that these modules can run on different clusters. To achieve fault-tolerance different clusters may employ different check pointing schemes. For example, some may use coordinated schemes, while some other may use communication-induced schemes. It may complicate the recovery process. In this paper, we have addressed the complex problem of recovery for cluster computing environment. The proposed approach handles both inter cluster orphan and lost messages unlike the existing works in this area. We first propose an algorithm to determine a recovery line so that there does not exist any inter cluster orphan message between any pair of the cluster level check points belonging to the recovery line. The main feature of the proposed algorithm is that it can be executed simultaneously by all clusters in the cluster federation. Next we apply the sender-based message logging idea to effectively handle all inter cluster lost messages to ensure correctness of computation

A Survey on Software Cost Estimation Techniques

The ability to accurately estimate the cost needed to complete a specific project has been a challenge over the past decades. For a successful software project, accurate prediction of the cost, time and effort is a very much essential task. This paper presents a systematic review of different models used for software cost estimation which includes algorithmic methods, non-algorithmic methods and learning-oriented methods. The models considered in this review include both the traditional and the recent approaches for software cost estimation. The main objective of this paper is to provide an overview of software cost estimation models and summarize their strengths, weakness, accuracy, amount of data needed, and validation techniques used. Our findings show, in general, neural network based models outperforms other cost estimation techniques. However, no one technique fits every problem and we recommend practitioners to search for the model that best fit their needs

Giovanni II d'Aragona e la partecipazione del Regno di Sardegna e Corsica nella guerra civile catalana

This dissertation partially makes up for the lack of Sardinian, Italian and Iberian historiography, with particular reference to the role of John II of Aragon in the Kingdom of Sardinia and Corsica (1458-79). Given the considerable amount of documents available on the topic, mostly unpublished and stored in archives, both in Italy and abroad, it has been necessary to perform a scientific analysis of unpublished data; these data have then been integrated with those retrieved from published documents, along with data gathered from other literary sources and chronicles. As a result, our work has been subdivided into four sections, featuring a huge collection of documents. After an introduction on the scientific methodology applied to the research process, we have moved on to examine the kingdom of John II after his accession to the throne of Aragon and the reasons for the break out of the ten-year Catalan Civil War, as well as its repercussions on the crisis on the kingdom of Sardinia and Corsica. The period after the Civil War has been taken into consideration and, and particular attention has been paid to the end of the marquisate of Oristano, which has marked the history of the Kingdom of Sardinia and Corsica in the 1470’s. Finally, in the appendix, 111 documents are to be found, with the summaries and the transcription of the most important texts used during the research, borrowed from both the Archive of the Crown of Aragon in Barcelona and the State Archive of Cagliari

Using nanoscale bioreactors to characterize sub-populations of CHO clones and screen transfected pools

Traditional means to quantify growth and production rates for antibody-expressing CHO lines involve sampling aliquots and supernatants from well plates that have been seeded with single cells. The number of clones studied is often limited by cloning efficiencies (typically 5-50%) and the inability to handle large numbers of well plates. The speed at which each clone can be measured is limited by the growth rates of cells and the number of cells required to perform each assay. Both of these factors lead to a practical throughput of 100s of clones screened over the course of 2-4 weeks. Furthermore, each readout of a clone offers little to no insight into the behavior of sub-populations within each clone since the aliquot or supernatant is just a small sample representing the entire population. Please click Additional Files below to see the full abstract

Studio sperimentale sulla degradazione della lettiera

It has been tested abaut litter's decomposition of oak, lentisc, pine in environment with vegetable covering and without it by some isopodes and diplopodes and on the whole microcenosys present on litters. We have also determinated the alimentary praeferendum of the about taxa