High-spin structure and Band Termination in 103^{103}Cd

Excited states of the neutron deficient $^{103}$Cd nucleus have been investigated via the $^{72}$Ge($^{35}$Cl, p3n) reaction at beam energy of 135 MeV by use of in-beam spectroscopic methods. Gamma rays depopulating the excited states were detected using the Gammasphere spectrometer with high-fold $\gamma$-ray coincidences. A quadrupole $\gamma$-ray coincidence analysis ($\gamma^{4}$) has been used to extend the known level scheme. The positive parity levels have been established up to $J = 35/2\hbar$ and $E_{x} = 7.071$ MeV. In addition to the observation of highly-fragmented level scheme belonging to the positive-parity sequences at E$_{x}\sim$ 5 MeV, the termination of a negative-parity sequence connected by $E2$ transitions has been established at $J = 47/2 \hbar$ and $E_{x} = 11.877$ MeV. The experimental results corresponding to both the positive- and negative-parity sequences have been theoretically interpreted in the framework of the core particle coupling model. Evidence is presented for a shape change from collective prolate to non-collective oblate above the $J^{\pi} = 39/2^{-}$ (8011 keV) level and for a smooth termination of the negative-parity band.Comment: 19 pages, 8 figures. Submitted to Phys. Rev.

Synthesis of β-amino alcohols by ring opening of epoxides with amines catalyzed by sulfated tin oxide under mild and solvent-free conditions

One significant and elegant method for creating β-amino alcohols, which are useful intermediates for the synthesis of many different natural and synthetic pharmaceutical compounds, is to open the rings of epoxides with amines. When sulfated tin oxide catalyst (2 mol%) is present, epoxides can open their rings and react with amines to produce corresponding β-amino alcohols in good to high yields under mild circumstances. Under clean circumstances and in a short amount of time, the reaction demonstrated high regioselectivity and functioned well with both aromatic and aliphatic amines at room temperature

Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

Glaucoma is a multi-factorial blinding disease in which genetic factors play an important role. Elevated intraocular pressure is a highly heritable risk factor for primary open angle glaucoma and currently the only target for glaucoma therapy. Our study helps to better understand underlying genetic and molecular mechanisms that regulate intraocular pressure, and identifies a new candidate gene, Cacna2d1, that modulates intraocular pressure and a promising therapeutic, pregabalin, which binds to CACNA2D1 protein and lowers intraocular pressure significantly. Because our study utilizes a genetically diverse population of mice with kno

Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

Glaucoma is a multi-factorial blinding disease in which genetic factors play an important role. Elevated intraocular pressure is a highly heritable risk factor for primary open angle glaucoma and currently the only target for glaucoma therapy. Our study helps to better understand underlying genetic and molecular mechanisms that regulate intraocular pressure, and identifies a new candidate gene, Cacna2d1, that modulates intraocular pressure and a promising therapeutic, pregabalin, which binds to CACNA2D1 protein and lowers intraocular pressure significantly. Because our study utilizes a genetically diverse population of mice with known sequence variants, we are able to determine that the intraocular pressure-lowering effect of pregabalin is dependent on the Cacna2d1 haplotype. Using human genome-wide association study (GWAS) data, evidence for association of a CACNA2D1 single-nucleotide polymorphism and primary open angle glaucoma is found. Importantly, these results demonstrate that our systems genetics approach represents an efficient method to identify genetic variation that can guide the selection of therapeutic targets

Analysis and effect of multi-fuel and practical constraints on economic load dispatch in the presence of Unified Power Flow Controller using UDTPSO

This paper presents an attempt to analyze the effect of multi-fuel and practical constraints on economic load dispatch problem using a novel uniform distributed two-stage particle swarm optimization (UDTPSO) algorithm without and with unified power flow controller (UPFC) while satisfying equality, inequality, practical constraints such as ramp-rate and prohibited operating zone (POZ) limits and device operating limits. A Novel severity function is formulated based on the transmission line overloads and bus voltage violations to identify an optimal location to install UPFC. A multi-objective optimization problem is solved for multi-fuel non-convex cost and transmission power loss objectives. Obtained results for considered standard test functions and electrical systems indicate the effectiveness of the proposed algorithm and can obtain efficient solution when compared to existing methods. Hence, the proposed method is a promising method and can be easily applied to optimize the power system objectives

Multi-objective optimization in the presence of practical constraints using non-dominated sorting hybrid cuckoo search algorithm

A novel optimization algorithm is proposed to solve single and multi-objective optimization problems with generation fuel cost, emission, and total power losses as objectives. The proposed method is a hybridization of the conventional cuckoo search algorithm and arithmetic crossover operations. Thus, the non-linear, non-convex objective function can be solved under practical constraints. The effectiveness of the proposed algorithm is analyzed for various cases to illustrate the effect of practical constraints on the objectives' optimization. Two and three objective multi-objective optimization problems are formulated and solved using the proposed non-dominated sorting-based hybrid cuckoo search algorithm. The effectiveness of the proposed method in confining the Pareto front solutions in the solution region is analyzed. The results for single and multi-objective optimization problems are physically interpreted on standard test functions as well as the IEEE-30 bus test system with supporting numerical and graphical results and also validated against existing methods

Security constrained economic load dispatch in the presence of interline power flow controller using modified BAT algorithm

The utilization of electrical energy due to urbanization and industrialization is increasing day by day, and due to this, there is chance of increasing the uncertainties in a given power system and that affects the economy of the country. The conventional power system in the presence of flexible AC transmission system (FACTS) controllers is an alternative to solve this problem and can increase the power system capability to handle rapid changes in operating conditions of the system. In general, multi-line FACTS controllers are effective than single line FACTS controllers. In this paper, a detailed mathematical modeling of IPFC is presented and the effect of an optimal location is also analyzed. A novel optimization algorithm i.e. modified BAT algorithm is proposed to solve optimal power flow problem in the presence of IPFC including system constraints and device limits. The proposed methodology has been tested on standard test systems

Available transfer capability evaluation and enhancement using various FACTS controllers: Special focus on system security

Nowadays, because of the deregulation of the power industry the continuous increase of the load increases the necessity of calculation of available transfer capability (ATC) of a system to analyze the system security. With this calculation, the scheduling of generator can be decided to decrease the system severity. Further, constructing new transmission lines, new substations are very cost effective to meet the increasing load and to increase the transfer capability. Hence, an alternative way to increase the transfer capability is use of flexible ac transmission system (FACTS) controllers. In this paper, SSSC, STACOM and UPFC are considered to show the effect of these controllers in enhancing system ATC. For this, a novel current based modeling and optimal location strategy of these controllers are presented. The proposed methodology is tested on standard IEEE-30 bus and IEEE-57 bus test systems with supporting numerical and graphical results

Analyzing the effect of dynamic loads on economic dispatch in the presence of interline power flow controller using modified BAT algorithm

Now a day, non-uniform increase of demand on a power system turns the research toward the dynamic analysis. In this paper, to perform dynamic analysis and to solve economic load dispatch problem using optimal power flow (OPF), four realistic load levels are considered. Further, the effectiveness of the objective has been enhanced in the presence of interline power flow controller (IPFC). An optimal location identification methodology for IPFC based on line stability index (LSI) is also presented. The effect of ramp-rate limits on generations and the effect of dynamic loads on generation fuel cost and transmission losses are also analyzed on standard IEEE-30 bus and real time 23 bus test systems with supporting validations, numerical and graphical results

Combining cycloisomerization with trienamine catalysis: a regiochemically flexible enantio- and diastereoselective synthesis of hexahydroindoles

The synthesis of polysubstituted hexahydroindoles through trienamine-organocatalyzed cycloadditions of pyrrolidinyl dienals, prepared by palladium-catalyzed cycloisomerization, is reported. The cycloadditions of this novel class of dienals proceed with excellent levels of enantio- and diastereoselectivity, with the regioselectivity of cycloaddition with respect to the tethering ring readily tuned through design of the cycloisomerization substrate. This work culminates in the first examples of double-stereodifferentiating trienamine catalysis, where catalyst stereocontrol dominates facial selectivity in the cycloaddition, affording azacyclic products that are specifically functionalized at every position