FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISINTEGRATING TABLETS OF CINITAPRIDE HYDROGEN TARTARATE BY USING DIRECT COMPRESSION TECHNIQUE

Objective: In the present study, efforts were taken to develop fast disintegrating tablets of Cinitapride hydrogen tartrate, is a gastro-prokinetic agent and antiulcer agent with an objective to achieve rapid disintegration, and further improving the bioavailability of the drug. Also, to resolve the swallowing problems (Dysphasia) in pediatric, geriatric patients by rapid disintegration in saliva and improve the patient compliance.Methods: Fast disintegrating tablets were prepared by direct compression method using superdisintegrants like crospovidone (CP), croscarmellose sodium (CCS), sodium starch glycolate (SSG) and combination of super-disintegrants in different concentrations. The prepared formulations were evaluated for the pre-compression parameters like bulk density, tapped density, Carr's compressibility, Hausner's ratio and angle of repose. The prepared batches of fast disintegrating tablets of Cinitapride hydrogen tartarate were evaluated for hardness, weight variation, thickness, friability, drug content, disintegration time, wetting time, water absorption ratio, and in vitro dissolution profile.Results: Bulk density and tapped density were found in the range of 0.412–0.432 g/cc and 0.507–0.528 g/cc respectively. In all formulations, tablet weight and thickness were within mean±9.5% and mean±5% respectively. Wetting time values lie between 19.76 to 39.53 sec. Water absorption ratio ranged from 57.30 to 78.82 %. The in vitro disintegration time for all the 12 formulations varied from 17.43 to 38.61 seconds. Formulation F8 which contained crosspovidone have recorded drug release 96.94±0.47% at the end of 30 min.Conclusion: The formulation containing crospovidone (F8) showed better performance in terms of disintegration time and drug release when compared to other formulations

Hybrid Broadcast Encryption and Group Key Agreement Protocol with Precise Cipher Texts

In cryptographic system so as to manage the group of members, the group key management protocol is used and it also should provide the security to the group of members which means the communication among the members will be done in secure manner. Broadcast Encryption (BCE) provides a key it arise common for all the members in the group during the encryption and all the associated members can decipher the message with the same mutual key but cannot stop decrypt the message by individuals. Broadcast encipher algorithm sends a secure transmit note to the entire members with the distributed key to decrypt the message with trusted third party. The conventional BE scheme fully relies on third party reliable key generator server machine, the responsibility of the third party server is to generating the undisclosed deciphering keys for the entire collection members and the group members are responsible for decrypt the messages which are encrypted under a common encrypted key. The purpose of Group Key Accord (GKAP) protocol is for negotiate all the assembly members and designing a familiar encryption key through the network. With the GKAP the group members are responsible for generating universal encipher key and it permits simply the group people to decrypt the cipher text which is encrypted by group members by using the shared encryption key but this GKA protocol it is not possible to exclude any members from the group to decrypt the cipher text shared under the common encryption key. In this paper we will combine these two techniques to produce a novel approach called as the Hybrid Broadcast Encryption (HBCE). In this innovative primeval all the cluster of participants agree and produces a widespread encipher key but though each individual having their own decipher key, So that the sender by looking the encryption key he will bound the deciphering to limited members for his abundance

NOVEL SUBCUTANEOUS SUSTAINED RELEASE NANOPARTICLES ENCAPSULATING LOW MOLECULAR WEIGHT HEPARIN (LMWH): PREPARATION, CHARACTERIZATION AND EVALUATION

Objective: The objective of the current research work was to prepare and evaluate novel subcutaneous sustained release polymeric nanoparticles for low molecular weight heparin (LMWH).Methods: In this study, we prepared subcutaneously administered polymeric nanoparticles encapsulating LMWH using different grades of polycaprolactons (PCL) (14k, 45k, 80k) and 0.1% Polyvinyl alcohol (PVA) solution as surfactant by employing water–in-oil in-water (w/o/w) emulsion and evaporation method. The formulated nanoparticles were evaluated for size, shape, zeta potential, in vitro drug release, and in vivo biological activity (anti factor Xa activity) using standard kit, antithrombotic activity in thrombosis induced rat model. Drug and polymer interactions in the nanoparticles were evaluated using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD).Results: Scanning electron microscopic (SEM) studies on the nanoparticles confirmed the formation of spherical particles with smooth surface. The size of the formed nanoparticles were about 415-495 nm. The % entrapment of nanoparticles was found to be between 69-81%. Nanoparticles showed slow and sustained pattern of release for about 59-65 % in 48 h. Optimized nanoparticles exhibited excellent improvement in pharmacokinetic parameters and showed good antithrombotic activity, Activated partial thromboplastin time (aPTT) activity when compared to free drug. FTIR studies indicated that there was no loss in chemical integrity of the drug upon fabrication into nanoparticles. XRD results demonstrated that the drug changed its physical form in the formulation.Conclusion: The results of this study revealed that subcutaneous nanoparticles were excellent candidates for sustained drug delivery of LMWH to avoid repeated subcutaneous administration.Keywords: Low molecular weight heparin, Subcutaneous, Stability, Polycaprolactone, Venous thrombosis, Activated partial thromboplastin timeÂ

DESIGN, DEVELOPMENT AND IN VITRO EVALUATION OF COMBINED FLOATING-BIOADHESIVE DRUG DELIVERY SYSTEMS OF ATENOLOL

Objective: A combination of the Floating-Bioadhesive system will overcome the drawbacks of floating & bioadhesive systems if used alone and will have a significant effect on improving the therapeutic effect of the drug involved. The present study involves the formulation and in vitro evaluation of atenolol floating-Bioadhesive tablet for prolonged residence in the stomach for the treatment of hypertension.Methods: The tablets were prepared by direct compression method using directly compressible polymers such as, Hydroxy Propyl Methyl Cellulose (HPMC) K15M, Guar gum, Carbopol, and sodium alginate. The tablets were evaluated for buoyancy test, mucoadhesion force, swelling study, drug content, ex-vivo mucoadhesion strength and in-vitro release profile. Sodium bicarbonate was used for producing the effervescent base for the buoyancy of tablets.Results: Formulation F9 contains polymer sodium alginate which has shown highest percentage cumulative drug release up to 99.12%. No significant change was observed in physical appearance, drug content, float ability or in vitro dissolution pattern after storage at 45 °C/75% RH for three months.Conclusion: In this present research work it was concluded that the cumulative drug release increased when the viscosity and concentration of the polymer was increased. The swelling properties were increased with increasing polymer concentration and contributed to the drug release from the tablet matrix.Â

EVALUATION FOR NEPHROPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF ALLIUM CEPA LINN. IN GENTAMICIN-INDUCED NEPHROTOXICITY IN RATS

ABSTRACTObjective: Kidney diseases are a major problem of worldwide proportions, and renal damage is very common since kidney has the capacity to excretetoxic substances. This study aimed to evaluate the protective effect of the ethanolic extract of Allium cepa Linn. (EEAC) plant leaves against gentamicininducednephrotoxicity in rats.Methods: Nephroprotective activity was estimated by inducing gentamicin (100 mg/kg) to all the groups of animals; acute kidney dysfunction is anevidenced by significant elevation of serum creatinine, total protein and decreased body weight with multiple histological damages.Results: Treatment with the A. cepa Linn. has shown significant (p<0.01 and p<0.001) dose-dependent improvement in the body weight at the doseof 200 and 400 mg/kg and also shown significant improvement by protecting the kidney from the oxidative stress. It is also identified that treatmentwith A. cepa significantly lowered the level of serum creatinine, total protein when compared with the toxic group.Conclusion: Nephroprotective activity of EEAC treatment was found compared with the standard group (Vitamin E – 250 mg/kg) and control groupagainst the toxic control group animals in parameters including serum creatinine, total protein, kidney weights, and body weights. The histopathologicalstudies were also evinced the protective effect of EEAC.Keywords: Nephroprotective activity, Gentamicin, Nephrotoxicity, Allium cepa Linn

Evaluation of anti ulcer activity of ethanolic root extract of Beta vulgaris in rats

Background: Beta vulgaris (chenopodiacea) is a plant reported for its variety of ethnic medicinal uses. Hence we have planned to screen anti ulcer activity of root of the plant with the alcoholic extract. Root powders successively extracted with alcohol and were subjected for phytochemical screening to identify different phytoconstituents.Methods: Anti ulcer activity was evaluated in various animal models like pylorus ligation and ethanol induced ulcer models in rats.Results: Preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, carbohydrates, saponins, polyphenols. No mortality was observed with root extract up to maximum dose level of 4g/kg. Further alcoholic extract of 200 and 400mg/ kg / p.o significantly (p˂0.01) reduced the ulcer score, ulcer number, ulcer index, free acidity and total acidity in pylorus ligation and ethanol induced ulcer models in rats.Conclusions: The present study revealed that the root extract of Beta vulgaris has antiulcer activity

SYNTHESIS OF PRODRUGS OF MEFENAMIC ACID AND THEIR IN VIVO EVALUATION

Objective: The purpose of the study was to synthesize prodrugs of mefenamic acid, to be used as Anti inflammatory drug with fewer adverse effects. Methods: The drug was covalently bonded to PEG 1500 (polyethylene glycol) and PEG 6000 as such and with a linker glycine. The prodrugs were characterized by FT-I.R and N.M.R. For the drug release studies, all the prodrugs were subjected to pH 1.2 and pH 7.2. For the anti inflammatory activity, Carrageenan induced rat paw edema method was followed and for Ulcer protecting activity, Pylorus ligation method was used, the prodrugs were administered to male Sprague-Dawley rats. Results: The results suggested that the prodrugs of mefenamic acid, the drug release was higher at pH 7.2 than at pH 1.2. The result obtained for anti inflammatory activity was comparable to the standard drug of mefenamic acid. For ulcers, the prodrugs were found to possess Ulcer curing property higher than the standard drug. Conclusion: The prodrugs thus synthesized possess anti inflammatory activity as well as good ulcer protecting activity, can be used instead of standard drug

Addressing the IoT Schemes for Securing the Modern Healthcare Systems with Block chain Neural Networks

This paper provides a wide-range of literature review of various IOT with AI based enabling wearable technologies and protocols used for medical (IoT) with a taught of examining the present and future smart health care technologies. Despite recent advances in medical systems, biomedical hardware, the growth of IoT in medicine continues to advance in terms of biomedical hardware, monitoring figures like cancer patient data disease indicators, temperature levels, oxygen levels, and glucose levels. In the near future, medical IoT is expected to replace the old traditional healthcare systems to smart Ai-IoT based healthcare systems. In our paper we provided a theoretical approach of the most relevant protocols and wearable technologies used for the IoT health care medical systems. We also provided a proposed smart AI based intelligent IoT frameworks for hospital systems settings

ANN and RSM based Modeling of Moringa Stenopetala Seed Oil Extraction: Process Optimization and Oil Characterization

Moringa Stenopetala is a plant species that is endemic to the southern region of Ethiopia. It is primarily cultivated for its nutritional value and is considered an important food source. The present research aimed to analyse the physicochemical properties of Moringa Stenopetala seed oil (MSO) obtained through solvent extraction method utilising hexane as the solvent. The collection of seeds was conducted in Adama, which is situated in the East Shawa zone of Oromia, Ethiopia. Prior to the extraction procedure, the seeds' average moisture content, crude ash, fibre, protein, and oil content were analysed and found to be 6.27%, 7.8%, 2.7%, 26.5%, and 43.2%, respectively. Using the Response Surface Method (RSM) and Artificial Neural Network (ANN), the extraction process was modeled. The study utilised numerical solutions to determine the optimal process parameters for maximising oil yield during extraction. The results indicated that a particle size of 0.85mm, a temperature of 85°C, and an extraction time of 4.75 hours were the most effective parameters. Furthermore, an investigation was conducted on the physical and chemical properties of the oil obtained under optimised conditions

Obesity: An overview on its current perspectives and treatment options

Obesity is a multi-factorial disorder, which is often associated with many other significant diseases such as diabetes, hypertension and other cardiovascular diseases, osteoarthritis and certain cancers. The management of obesity will therefore require a comprehensive range of strategies focussing on those with existing weight problems and also on those at high risk of developing obesity. Hence, prevention of obesity during childhood should be considered a priority, as there is a risk of persistence to adulthood. This article highlights various preventive aspects and treatment procedures of obesity with special emphasis on the latest research manifolds