cis-Bis[(4-nitro­phen­yl)cyanamido-κN 1]bis­(1,10-phenanthroline-κ2 N,N′)nickel(II) methanol monosolvate

In the title compound, [Ni(C7H4N3O2)2(C12H8N2)2]·CH3OH, the NiII atom is six-coordinated in a distorted N6 octa­hedral geometry and is chelated by two phenanthroline ligands and two phenyl­cyanamide groups which occupy cis positions. The (4-nitro­phen­yl)cyanamide anions act as monodentate ligands. There is one classical inter­molecular O—H⋯N hydrogen bond and several C—H⋯O hydrogen bonds are also observed

catena-Poly[[(dimethyl­formamide-κO)cobalt(II)]-bis­[μ-(4-nitro­phenyl)­cyanamido]-κ2 N 1:N 3;κ2 N 3:N 1]

In the title coordination polymer, [Co(C7H4N3O2)2(C3H7NO)]n, the CoII atom is five-coordinated in a distorted square-pyramidal CoON4 geometry with the O atom from a dimethyl­formamide mol­ecule in an equatorial position. The bridging phenyl­cyanamide anions generate an infinite chain propagating in [001]

catena-Poly[[(dimethyl­formamide-κO)copper(II)]-bis­(μ-4-nitro­phenyl­cyanamido-κ2 N 1:N 3)]

In the title compound, [Cu(C7H4N3O2)2(C3H7NO)], the CuII atom is five-coordinated in a distorted square-pyramidal geometry, with the N atoms in equatorial positions and the dimethyl­formamide O atom in an axial position. The dihedral angle between adjacent benzene rings is 70.33 (12)°

New cyclometalated ir(iii) complexes with ncn pincer and meso-phenylcyanamide bodipy ligands as efficient photodynamic therapy agents

A new class of cyclometalated iridium((III)) with NCN pincer and meso-phenylcyanamide BODIPY ligands of the formula [Ir(L)(PPY)(Pcyd-BODIPY)], 1, [Ir(L)(PIQ)(Pcyd-BODIPY)], 2, in which HL: 5-methoxy-1,3-bis (1-methyl-1H-benzo[d]imidazol-2-yl) benzene, Pcyd-BODIPY: 8-(4-phenylcyanamide) BODIPY, PPY: 2-phenylpyridine, PIQ: 1-phenylisoquinoline have been synthesized and studied for photodynamic therapy (PDT). The photophysical properties, DNA binding, DNA photocleavage, cellular uptake, thioredoxin reductase activity, reactive oxygen species (ROS) generation, and cellular apoptosis of the complexes have also been studied. Therefore, we present a conceivable biologically applicable PDT modality that develops persuasively designed photoactivatable Ir((III)) complexes

Supplier selection under uncertainty using Interval Compromise Programming

Now days one of the main strategies and policies of firms is purchasing parts from external suppliers. For decision making about selecting suppliers, are considered the different criteria. But because of changes of management levels and external suppliers strategies, could not determine input data precisely. Hence, considering supplier selection problem with regard to the uncertain criteria is necessary. In this paper, a combinatorial model from the well-known method of Compromise Programming (CP) and Interval Programming will be proposed that is called Interval Compromise Programming (ICP). The model can be used for optimizing multi-objective interval problems. For illustrating the proposed model, will be presented a supplier selection problem by considering the objectives of minimizing rejects and purchase cost and maximizing quality of purchased products, where are considered the input parameters as interval numbers. The obtained results compared to the ideal value of each objective can present a representation from situation of optimistic and pessimistic of the problem under uncertainty

Cytotoxicity and antimicrobial activity of triorganotin(IV) complexes of phenylcyanamide prepared by sonochemical synthesis

This article describes the synthesis and characterization of novel triorganotin(IV) complexes and their potential medicinal applications. Triorganotin(IV) complexes with formulas [(SnMe3)(2)(mu-bp)(H2O)(2)], 1, and [(SnMe3)(4-NO(2)pcyd)], 2, (Me: methyl, bpH(2): 4,4\u27-dicyanamidobiphenyl and 4-NO(2)pcyd: 4-nitrophenylcyanamide) have been synthesized via a sonochemical process and characterized using multinuclear NMR (H-1, C-13 and Sn-119), Mossbauer spectroscopy, elemental analysis, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Compounds 1 and 2 were evaluated for their DNA/protein binding with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA), respectively. The in vitro cytotoxicity of 1 and 2 was examined against A549, Du145, HeLa and MCF-7 cancer cell lines. For 1, a promising growth inhibitory effect against HeLa cells was observed that is slightly higher than that of cisplatin. Moreover, the antimicrobial activity of 1 and 2 against different strains of pathogenic bacteria and fungi were tested. The free radical scavenging ability (OH, NO) of 1 and 2 was assessed. (C) 2015 Elsevier B.V. All rights reserved.We are grateful for the financial support from the Department of Chemistry, Isfahan University Of Technology (IUT).2017-09-2

Copper(II), cobalt(II) and nickel(II) complexes of lapachol: synthesis, DNA interaction, and cytotoxicity

<p>Three novel copper(II), cobalt(II), and nickel(II) complexes of lapachol (Lap) containing 110-phenanthroline (phen) ligand, [M(Lap)₂(phen)] (M=Cu(II), <b>1</b>, Co(II), <b>2</b>, and Ni(II), <b>3</b>), have been synthesized and characterized using, elemental analysis and spectroscopic studies. Their interactions with calf thymus DNA (CT DNA) were investigated using viscosity, thermal denaturation, circular dichorism, fluorescence quenching, and electronic absorption spectroscopy. The DNA cleavage abilities of <b>1</b>–<b>3</b> have been studied, where cleavage activity of copper complex <b>1</b> is more than the complexes <b>2</b> and <b>3</b>. The <i>in vitro</i> cytotoxic potential of the complexes <b>1–3</b> against human cervical carcinoma (HeLa), human liver hepatocellular carcinoma (HepG-2), and human colorectal adenocarcinoma (HT-29) cells indicated their promising antitumor activity with quite low IC₅₀ values in the range of .15–2.41 μM, which are lower than those of cisplatin.</p