A six-phase transverse-flux-reversal linear machine for low-speed reciprocating power generation

In this paper, a 6-phase permanent-magnet flux-reversal linear machine for low-speed reciprocating power generation is presented. By increasing the phase number, the phase current is reduced for the same rated power which results in a lower ohmic loss. In addition, the thrust force ripple can be reduced accordingly. By borrowing the transverse-flux concept, the electric loading and the magnetic loading is decoupled and the thrust density can be improved accordingly. The stator of the proposed machine adopts the modular design, and each phase is magnetically decoupled with each other which gives more flexibility and controllability of the generator. Based on the same topology, the proposed machine can be extended to a machine with an arbitrary number of phase to suit different applications.published_or_final_versio

A transverse flux permanent magnet linear generator for hybrid electric vehicles

Article: TD-007358This paper presents a transverse flux permanent magnet (TFPM) linear generator for the free-piston generation application, which not only possessing the merits of the existing TFPM machine, but also providing a simple structure which is essential for power generation with maintenance-free operation. Also, the machine configuration is optimized such that the induced voltage is maximized while the cogging force is minimized. Hence, a 2-phase linear TFPM is resulted, which is well supported by performance analysis.published_or_final_versio

A low-speed linear harmonic generator for grid-tied and stand-alone operation using hybrid excitation topology

Paper no. BP-09Since intermediate mechanical conversion mechanisms for speed, torque and motion conversion can be entirely eliminated, the direct-drive wave power generation attracts more and more attention [1]. Among various proposed generators, the permanent-magnet (PM) vernier generator is considered as a viable solution for the wave energy harvesting. This generator can efficiently harness this low-speed and high-power energy source via a so-called vernier effect by utilizing the effective harmonic magnetic field [2]. However, since only PMs are engaged for field excitation and the harmonic magnetic field is adopted, it is incapable to provide a flexible voltage control and power factor improvement. Moreover, the voltage regulation is incredible high. The purpose of this paper is to design a linear harmonic generator for producing electricity in a wave farm. Except for the PM excitation, the proposed generator is equipped with a set of DC field winding for the hybrid excitation. With this merit, the proposed generator exhibits a satisfactory performance for voltage regulation and power factor improvement which is desirable for both grid-tied and stand-alone operation [3]. © 2015 IEEE.published_or_final_versio

The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) regulates the chemo-sensitivity of liver cancer cells

Poster Session 6 - New Drug Targets: no. P6.04BACKGROUND: The centrosomal protein, TAX1 binding protein 2 (TAX1BP2) was first identified as a cellular interacting partner of HTLV-I virus oncoprotein, TAX1. Further investigation has shown that TAX1BP2 was targeted by TAX1 to induce supernumerary centrosome in TAX1-expressing cells. Recently, TAX1BP2 was found to be frequently underexpressed in hepatocellular carcinoma (HCC) and underexpression of TAX1BP2 suppressed the activation of tumor suppressor p53 in a p38 MAPK dependent manner, suggesting that TAX1BP2 is a putative tumor suppressor in HCC. Here we provide ...published_or_final_versio

Design of a high-speed superconducting bearingless machine for flywheel energy storage systems

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Wireless power transfer and fault diagnosis of high-voltage power line via robotic bird

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PAK4 phosphorylates p53 at serine 215 to promote liver cancer metastasis

PAK4 kinase contributes to signaling pathways controlling cancer cell transformation, invasion and survival, but its clinicopathological impact has begun to emerge only recently. Here we report that PAK4 overexpression in hepatocellular carcinoma (HCC) conveys aggressive metastatic properties. A novel nuclear splice isoform of PAK4 lacking exon 2 sequences was isolated as part of our studies. By stably overexpressing or silencing PAK4 in HCC cells we showed that it was critical for their migration. Mechanistic investigations in this setting revealed that PAK4 directly phosphorylated p53 at S215, which not only attenuated transcriptional transactivation activity but also inhibited p53-mediated suppression of HCC cell invasion. Taken together, our results showed how PAK4 overexpression in HCC promotes metastatic invasion by regulating p53 phosphorylation.postprin

CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells

CDK5 regulatory subunit associated protein 3 (CDK5RAP3) is a novel activator of PAK4 and processes important pro-metastatic function in hepatocarcinogenesis. However, it remains unclear if there are other mechanisms by which CDK5RAP3 promotes HCC metastasis. Here, we showed that in CDK5RAP3 stable knockdown SMMC-7721 HCC cells, p14(ARF) tumor suppressor was upregulated at protein and mRNA levels, and ectopic expression of CDK5RAP3 was found to repress the transcription of p14(ARF). Using chromatin immunoprecipitation assay, we demonstrated that CDK5RAP3 bound to p14(ARF) promoter in vivo. Furthermore, knockdown of p14(ARF) in CDK5RAP3 stable knockdown HCC cells reversed the suppression of HCC cell invasiveness mediated by knockdown of CDK5RAP3. Taken together, our findings provide the new evidence that overexpression of CDK5RAP3 promotes HCC metastasis via downregulation of p14(ARF).published_or_final_versio

IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-kB activation

Hepatocellular carcinoma (HCC) is one of the major malignancies worldwide and is associated with poor prognosis due to the high incidences of metastasis and tumor recurrence. Our previous study showed that overexpression of p21-activated protein kinase 1 (PAK1) is frequently observed in HCC and is associated with a more aggressive tumor behavior, suggesting that PAK1 is a potential therapeutic target in HCC. In the current study, an allosteric small molecule PAK1 inhibitor, IPA-3, was evaluated for the potential in suppressing hepatocarcinogenesis. Consistent with other reports, inhibition of PAK1 activity was observed in several human HCC cell lines treated with various dosages of IPA-3. Using cell proliferation, colony formation and BrdU incorporation assays, we demonstrated that IPA-3 treatment significantly inhibited the growth of HCC cells. The mechanisms through which IPA-3 treatment suppresses HCC cell growth are enhancement of apoptosis and blockage of activation of NF-κB. Furthermore, our data suggested that IPA-3 not only inhibits the HCC cell growth, but also suppresses the metastatic potential of HCC cells. Nude mouse xenograft assay demonstrated that IPA-3 treatment significantly reduced the tumor growth rate and decreased tumor volume, indicating that IPA-3 can suppress the in vivo tumor growth of HCC cells. Taken together, our demonstration of the potential preclinical efficacy of IPA-3 in HCC provides the rationale for cancer therapy.published_or_final_versio