3,786 research outputs found
Development of EHD Ion-Drag Micropump for Microscale Electronics Cooling Systems
In this investigation, the numerical simulation of electrohydrodynamic (EHD)
ion-drag micropumps with micropillar electrode geometries have been performed.
The effect of micropillar height and electrode spacing on the performance of
the micropumps was investigated. The performance of the EHD micropump improved
with increased applied voltage and decreased electrode spacing. The optimum
micropillar height for the micropump with electrode spacing of 40m and
channel height of 100m at 200V was 40m, where a maximum mass flow
rate of 0.18g/min was predicted. Compared to that of planar electrodes, the 3D
micropillar electrode geometry enhanced the overall performance of the EHD
micropumps.Comment: Submitted on behalf of TIMA Editions
(http://irevues.inist.fr/tima-editions
Disorder in DNA-Linked Gold Nanoparticle Assemblies
We report experimental observations on the effect of disorder on the phase
behavior of DNA-linked nanoparticle assemblies. Variation in DNA linker lengths
results in different melting temperatures of the DNA-linked nanoparticle
assemblies. We observed an unusual trend of a non-monotonic ``zigzag'' pattern
in the melting temperature as a function of DNAlinker length. Linker DNA
resulting in unequal DNA duplex lengths introduces disorder and lowers the
melting temperature of the nanoparticle system. Comparison with free DNA
thermodynamics shows that such an anomalous zigzag pattern does not exist for
free DNA duplex melting, which suggests that the disorder introduced by unequal
DNA duplex lengths results in this unusual collective behavior of DNA-linked
nanoparticle assemblies.Comment: 4 pages, 4 figures, Phys.Rev.Lett. (2005), to appea
Microscopic Description of Band Structure at Very Extended Shapes in the A ~ 110 Mass Region
Recent experiments have confirmed the existence of rotational bands in the A
\~ 110 mass region with very extended shapes lying between super- and
hyper-deformation. Using the projected shell model, we make a first attempt to
describe quantitatively such a band structure in 108Cd. Excellent agreement is
achieved in the dynamic moment of inertia J(2) calculation. This allows us to
suggest the spin values for the energy levels, which are experimentally
unknown. It is found that at this large deformation, the sharply down-sloping
orbitals in the proton i_{13/2} subshell are responsible for the irregularity
in the experimental J(2), and the wave functions of the observed states have a
dominant component of two-quasiparticles from these orbitals. Measurement of
transition quadrupole moments and g-factors will test these findings, and thus
can provide a deeper understanding of the band structure at very extended
shapes.Comment: 4 pages, 3 eps figures, final version accepted by Phys. Rev. C as a
Rapid Communicatio
Real-time Loss Estimation for Instrumented Buildings
Motivation. A growing number of buildings have been instrumented to measure and record
earthquake motions and to transmit these records to seismic-network data centers to be archived and
disseminated for research purposes. At the same time, sensors are growing smaller, less expensive to
install, and capable of sensing and transmitting other environmental parameters in addition to
acceleration. Finally, recently developed performance-based earthquake engineering methodologies
employ structural-response information to estimate probabilistic repair costs, repair durations, and
other metrics of seismic performance. The opportunity presents itself therefore to combine these
developments into the capability to estimate automatically in near-real-time the probabilistic seismic
performance of an instrumented building, shortly after the cessation of strong motion. We refer to
this opportunity as (near-) real-time loss estimation (RTLE).
Methodology. This report presents a methodology for RTLE for instrumented buildings. Seismic
performance is to be measured in terms of probabilistic repair cost, precise location of likely physical
damage, operability, and life-safety. The methodology uses the instrument recordings and a Bayesian
state-estimation algorithm called a particle filter to estimate the probabilistic structural response of
the system, in terms of member forces and deformations. The structural response estimate is then
used as input to component fragility functions to estimate the probabilistic damage state of structural
and nonstructural components. The probabilistic damage state can be used to direct structural
engineers to likely locations of physical damage, even if they are concealed behind architectural
finishes. The damage state is used with construction cost-estimation principles to estimate
probabilistic repair cost. It is also used as input to a quantified, fuzzy-set version of the FEMA-356
performance-level descriptions to estimate probabilistic safety and operability levels.
CUREE demonstration building. The procedure for estimating damage locations, repair costs, and
post-earthquake safety and operability is illustrated in parallel demonstrations by CUREE and
Kajima research teams. The CUREE demonstration is performed using a real 1960s-era, 7-story, nonductile
reinforced-concrete moment-frame building located in Van Nuys, California. The building is
instrumented with 16 channels at five levels: ground level, floors 2, 3, 6, and the roof. We used the
records obtained after the 1994 Northridge earthquake to hindcast performance in that earthquake.
The building is analyzed in its condition prior to the 1994 Northridge Earthquake. It is found that,
while hindcasting of the overall system performance level was excellent, prediction of detailed damage
locations was poor, implying that either actual conditions differed substantially from those shown on
the structural drawings, or inappropriate fragility functions were employed, or both. We also found
that Bayesian updating of the structural model using observed structural response above the base of
the building adds little information to the performance prediction. The reason is probably that
Real-Time Loss Estimation for Instrumented Buildings
ii
structural uncertainties have only secondary effect on performance uncertainty, compared with the
uncertainty in assembly damageability as quantified by their fragility functions. The implication is
that real-time loss estimation is not sensitive to structural uncertainties (saving costly multiple
simulations of structural response), and that real-time loss estimation does not benefit significantly
from installing measuring instruments other than those at the base of the building.
Kajima demonstration building. The Kajima demonstration is performed using a real 1960s-era
office building in Kobe, Japan. The building, a 7-story reinforced-concrete shearwall building, was not
instrumented in the 1995 Kobe earthquake, so instrument recordings are simulated. The building is
analyzed in its condition prior to the earthquake. It is found that, while hindcasting of the overall
repair cost was excellent, prediction of detailed damage locations was poor, again implying either that
as-built conditions differ substantially from those shown on structural drawings, or that
inappropriate fragility functions were used, or both. We find that the parameters of the detailed
particle filter needed significant tuning, which would be impractical in actual application. Work is
needed to prescribe values of these parameters in general.
Opportunities for implementation and further research. Because much of the cost of applying
this RTLE algorithm results from the cost of instrumentation and the effort of setting up a structural
model, the readiest application would be to instrumented buildings whose structural models are
already available, and to apply the methodology to important facilities. It would be useful to study
under what conditions RTLE would be economically justified. Two other interesting possibilities for
further study are (1) to update performance using readily observable damage; and (2) to quantify the
value of information for expensive inspections, e.g., if one inspects a connection with a modeled 50%
failure probability and finds that the connect is undamaged, is it necessary to examine one with 10%
failure probability
Human parathyroid hormone fragment stimulates the de novo synthesis of prostaglandin endoperoxide synthase in chick calvaria
The human parathyroid hormone N-terminal fragment [hPTH-(1–34)] increases the conversion of exogenous unsaturated fatty acids to prostaglandins (PGs) in calvarial homogenates. Enzyme activities were completely blocked by indomethacin (5 × 10−7 M), a PG synthase inhibitor, and actinomycin D (5 μM), an inhibitor of transcription, by binding to DNA. In addition, a potent inhibitor of protein synthesis, cycloheximide (10 μM), totally inhibited the stimulating effect of hPTH-(1–34) on prostaglandin endoperoxide synthase (PG synthase, EC 1.14.99.1). The stimulatory effect of hPTH-(1–34) on PG synthase was also reduced by the addition of stannous chloride. However, epidermal growth factor (EGF), platelet-derived activating factor (PDGF), and ionophore A23187 did not show the same stimulating effect as hPTH-(1–34) on PG synthase in calvaria. The results further demonstrated that PG synthase is a membrane-bound enzyme in chick calvaria. In this communication, evidence is presented that hPTH-(1–34) stimulates the de novo synthesis of PG synthase as demonstrated by the increased activity in calvarial homogenates and microsomes
A Systematic Framework to Derive N-glycan Biosynthesis Process and the Automated Construction of Glycosylation Networks
published_or_final_versio
Probability Density Function of Longitudinal Velocity Increment in Homogeneous Turbulence
Two conditional averages for the longitudinal velocity increment u_r of the
simulated turbulence are calculated: h(u_r) is the average of the increment of
the longitudinal Laplacian velocity field with u_r fixed, while g(u_r) is the
corresponding one of the square of the difference of the gradient of the
velocity field. Based on the physical argument, we suggest the formulae for h
and g, which are quite satisfactorily fitted to the 512^3 DNS data. The
predicted PDF is characterized as
(1) the Gaussian distribution for the small amplitudes,
(2) the exponential distribution for the large ones, and (3) a prefactor
before the exponential function for the intermediate ones.Comment: 4 pages, 4 figures, using RevTeX3.
Passive Scalar: Scaling Exponents and Realizability
An isotropic passive scalar field advected by a rapidly-varying velocity
field is studied. The tail of the probability distribution for
the difference in across an inertial-range distance is found
to be Gaussian. Scaling exponents of moments of increase as
or faster at large order , if a mean dissipation conditioned on is
a nondecreasing function of . The computed numerically
under the so-called linear ansatz is found to be realizable. Some classes of
gentle modifications of the linear ansatz are not realizable.Comment: Substantially revised to conform with published version. Revtex (4
pages) with 2 postscript figures. Send email to [email protected]
High-Order Contamination in the Tail of Gravitational Collapse
It is well known that the late-time behaviour of gravitational collapse is
{\it dominated} by an inverse power-law decaying tail. We calculate {\it
higher-order corrections} to this power-law behaviour in a spherically
symmetric gravitational collapse. The dominant ``contamination'' is shown to
die off at late times as . This decay rate is much {\it
slower} than has been considered so far. It implies, for instance, that an
`exact' (numerical) determination of the power index to within
requires extremely long integration times of order . We show that the
leading order fingerprint of the black-hole electric {\it charge} is of order
.Comment: 12 pages, 2 figure
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