Indigenous Peoples' lands are critical for safeguarding vertebrate diversity across the tropics

Indigenous Peoples are long-term custodians of their lands, but only recently are their contributions to conservation starting to be recognized in biodiversity policy and practice. Tropical forest loss and degradation are lower in Indigenous lands than unprotected areas, yet the role of Indigenous Peoples' Lands (IPL) in biodiversity conservation has not been properly assessed from regional to global scales. Using species distribution ranges of 11,872 tropical forest-dependent vertebrates to create area of habitat maps, we identified the overlap of these species ranges with IPL and then compared values inside and outside of IPL for species richness, extinction vulnerability, and range-size rarity. Of assessed vertebrates, at least 76.8% had range overlaps with IPL, on average overlapping ~25% of their ranges; at least 120 species were found only within IPL. Species richness within IPL was highest in South America, while IPL in Southeast Asia had highest extinction vulnerability, and IPL in Dominica and New Caledonia were important for range-size rarity. Most countries in the Americas had higher species richness within IPL than outside, whereas most countries in Asia had lower extinction vulnerability scores inside IPL and more countries in Africa and Asia had slightly higher range-size rarity in IPL. Our findings suggest that IPL provide critical support for tropical forest-dependent vertebrates, highlighting the need for greater inclusion of Indigenous Peoples in conservation target-setting and program implementation, and stronger upholding of Indigenous Peoples' rights in conservation policy

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Re/Constructing Luba Past

info:eu-repo/semantics/publishe

Fieldwork

Description and interpretation of the excavations conducted from 2001 to 2005 at the site of Mersa/Wadi Gawasis on the Egyptian Red Sea coast

Iron production in second millennium AD pastoralist contexts on the Laikipia Plateau, Kenya

Iron has played an important role within East African pastoralist societies for many hundreds of years, yet the means by which iron was produced or obtained by these communities has not been thoroughly documented. The bulk of our understanding is presently based on a limited number of ethnographic and artefact studies, which have tended to focus on the functional and symbolic nature of iron objects themselves. We argue that the research presented here provides the first opportunity to add to this narrow knowledge base by reconstructing the iron production technologies of pastoralist communities in Laikipia, Kenya, using an archaeometallurgical approach. Seven furnaces and one iron-production refuse area were excavated at two discrete workshop sites in Laikipia, central Kenya, that date to the second half of the second millennium AD. The recovered archaeometallurgical materials were analysed using optical microscopy, SEM-EDS and ED-XRF. These techniques revealed that the smelting technologies in question were complex and sophisticated and that they utilised titania-rich black sands and lime-rich charcoal. Whereas the technical approach and raw materials were found to be similar at both sites studied, there was striking stylistic variation in furnace design for no apparent functional reason, which might suggest nuanced differences in the socio-cultural affiliations of the smelters who worked at these sites. This paper explores some of the possible reasons for these differences. In particular, by integrating archaeological data with existing ethnographic and ethnohistoric research from the region, we discuss the technological choices of the smelters and what this might tell us about their identities, as well as considering how future research should best be targeted in order to develop a greater understanding of the organisation of production within pastoralist central Kenya