Layer Formation Studies in Selective Laser Melting of Steel Powders

This paper advances the findings of the selective laser melting (SLM) of tool steel and stainless steel powders. The distinguishing feature is the melting of single layers in deep powder beds by a continuous CO2 laser. First, effect of process parameters on the surface roughness for each material is investigated. Based on these results combined with visual observation of the solidified tracks, the question is then discussed as how the processability of various type of steels is changed. The results show that surface morphology of layers is affected strongly by scan spacing, thereby giving a lower average roughness at reduced scan spacing. The effect of scan speed is also remarkable. In addition, other roughness parameters such as the peak height and skewness are found to be useful tools for evaluation of laser melted surfaces.Mechanical Engineerin

Further Developments in Process Mapping and Modelling in Direct Metal Selective Laser Melting

This paper advances previous reported work on the mapping and modelling of single tracks and layers produced in powder beds of tool steel and stainless steel powders by a CO2 laser. For single tracks it reports on predicted and simulated track masses. It validates the simulations, including the use of absorption close to 1.0 when cylindrical tracks are formed. It also reports on melt pool temperature calculations and estimated melt pool dimensions which are used, in conjunction with bed physical properties, to explain why the single tracks form as either continuous with a crescent shape cross-section, continuous with an elliptical section, discontinuously irregularly broken, discontinuously balled or only partially melted as scan speeds and laser powers change. It then extends its scope, experimentally, to consider effects of scan spacing on single layer formation.Mechanical Engineerin

Strength of the DTM RapidSteel 1.0 Material

This paper reports the results of a study into the strength of the DTM RapidSteel 1.0 material. Elastic modulus and strength of the metal/copper composite material was investigated as a function of the distance from the point of copper infiltration, the furnace cycle duration, and the furnace type. The microstructure of the RapidSteel material was also examined in an attempt to understand the science behind the infiltration process. The results have implications for the design of tools to be made using the RapidTool process in situations where the tool will be used as a production tool, rather than a prototype tool.Mechanical Engineerin

Modelling Simple Feature Creation in Selective Laser Sintering

A two dimensional finite difference thermal sintering model has been created to describe the Selective Laser Sintering process(SLS). It includes thermal property variation with position and temperature, and especially adaptive meshing to refine information in regions of high temperature gradients. It has been used to predict density and temperature in both single and multi layer sintering operations, corresponding to experimental results. This paper will present comparisons of theory and experiment for the SLS of simple geometries such as blocks, steps, and cylinders.Mechanical Engineerin

Photon collection from a trapped ion--cavity system

We present the design and implementation of a trapped ion cavity QED system. A single ytterbium ion is confined by a micron-scale ion trap inside a 2 mm optical cavity. The ion is coherently pumped by near resonant laser light while the cavity output is monitored as a function of pump intensity and cavity detuning. We observe a Purcell enhancement of scattered light into the solid angle subtended by the optical cavity, as well as a three-peak structure arising from strongly driving the atom. This system can be integrated into existing atom{photon quantum network protocols and is a pathway towards an efficient atom{photon quantum interface

Exploring the Cosmic Evolution of Habitability with Galaxy Merger Trees

We combine inferred galaxy properties from a semi-analytic galaxy evolution model incorporating dark matter halo merger trees with new estimates of supernova and gamma ray burst rates as a function of metallicity from stellar population synthesis models incorporating binary interactions. We use these to explore the stellar mass fraction of galaxies irradiated by energetic astrophysical transients and its evolution over cosmic time, and thus the fraction which is potentially habitable by life like our own. We find that 18 per cent of the stellar mass in the Universe is likely to have been irradiated within the last 260 Myr, with GRBs dominating that fraction. We do not see a strong dependence of irradiated stellar mass fraction on stellar mass or richness of the galaxy environment. We consider a representative merger tree as a Local Group analogue, and find that there are galaxies at all masses which have retained a high habitable fraction (>40 per cent) over the last 6 Gyr, but also that there are galaxies at all masses where the merger history and associated star formation have rendered galaxies effectively uninhabitable. This illustrates the need to consider detailed merger trees when evaluating the cosmic evolution of habitability.Comment: 11 page, 10 figures. MNRAS accepted 13th Dec 2017. Updated to match accepted version, with additional discussion of metallicity effect

Estimating the functional form for the density dependence from life history data

Two contrasting approaches to the analysis of population dynamics are currently popular: demographic approaches where the associations between demographic rates and statistics summarizing the population dynamics are identified; and time series approaches where the associations between population dynamics, population density, and environmental covariates are investigated. In this paper, we develop an approach to combine these methods and apply it to detailed data from Soay sheep (Ovis aries). We examine how density dependence and climate contribute to fluctuations in population size via age- and sex-specific demographic rates, and how fluctuations in demographic structure influence population dynamics. Density dependence contributes most, followed by climatic variation, age structure fluctuations and interactions between density and climate. We then simplify the density-dependent, stochastic, age-structured demographic model and derive a new phenomenological time series which captures the dynamics better than previously selected functions. The simple method we develop has potential to provide substantial insight into the relative contributions of population and individual-level processes to the dynamics of populations in stochastic environments

Prevalence and characteristics of gastrointestinal infections in men who have sex with men diagnosed with rectal chlamydia infection in the UK: an 'unlinked anonymous' cross-sectional study.

INTRODUCTION: Gastrointestinal infections (GII) can cause serious ill health and morbidity. Although primarily transmitted through faecal contamination of food or water, transmission through sexual activity is well described, especially among men who have sex with men (MSM). METHODS: We investigated the prevalence of GIIs among a convenience sample of MSM who were consecutively diagnosed with rectal Chlamydia trachomatis (CT) at 12 UK genitourinary medicine clinics during 10 weeks in 2012. Residual rectal swabs were coded, anonymised and tested for Shigella, Campylobacter, Salmonella, shiga toxin-producing Escherichia coli and enteroaggregative E. coli (EAEC) using a real-time PCR. Results were linked to respective coded and anonymised clinical and demographic data. Associations were investigated using Fisher's exact tests. RESULTS: Of 444 specimens tested, overall GII prevalence was 8.6% (95% CI 6.3% to 11.6%): 1.8% (0.9% to 3.6%) tested positive for Shigella, 1.8% (0.9% to 3.6%) for Campylobacter and 5.2% (3.5% to 7.7%) for EAEC. No specimens tested positive for Salmonella or other diarrhoeagenic E. coli pathotypes. Among those with any GII, 14/30 were asymptomatic (2/7 with Shigella, 3/6 with Campylobacter and 9/17 with EAEC). Shigella prevalence was higher in MSM who were HIV-positive (4.7% (2.1% to 10.2%) vs 0.5%(0.1% to 3.2%) in HIV-negative MSM; p=0.01). CONCLUSIONS: In this small feasibility study, MSM with rectal CT appeared to be at appreciable risk of GII. Asymptomatic carriage may play a role in sexual transmission of GII

Expression of somatostatin receptors 2 and 5 in circulating tumour cells from patients with neuroendocrine tumours.

BACKGROUND: Neuroendocrine tumours (NET) overexpress somatostatin receptors (SSTR) that can be targeted for therapy. Somatostatin receptor expression is routinely measured by molecular imaging but the resolution is insufficient to define heterogeneity. We hypothesised that SSTR expression could be measured on circulating tumour cells (CTCs) and used to investigate heterogeneity of expression and track changes during therapy. METHODS: MCF-7 cells were transfected with SSTR2 or 5 and spiked into donor blood for analysis by CellSearch. Optimum anti-SSTR antibody concentration and exposure time were determined, and flow cytometry was used to evaluate assay sensitivity. For clinical evaluation, blood was analysed by CellSearch, and SSTR2/5 immunohistochemistry was performed on matched tissue samples. RESULTS: Flow cytometry confirmed CellSearch was sensitive and that detection of SSTR was unaffected by the presence of somatostatin analogue up to a concentration of 100 ng ml(-l). Thirty-one NET patients were recruited: grade; G1 (29%), G2 (45%), G3 (13%), primary site; midgut (58%), pancreatic (39%). Overall, 87% had SSTR-positive tumours according to somatostatin receptor scintigraphy or 68-Ga-DOTATE PET/CT. Circulating tumour cells were detected in 21 out of 31 patients (68%), of which 33% had evidence of heterogeneous expression of either SSTR2 (n=5) or SSTR5 (n=2). CONCLUSIONS: Somatostatin receptors 2 and 5 are detectable on CTCs from NET patients and may be a useful biomarker for evaluating SSTR-targeted therapies and this is being prospectively evaluated in the Phase IV CALMNET trial (NCT02075606)