2,737 research outputs found

    Precision searches in dijets at the HL-LHC and HE-LHC

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    This paper explores the physics reach of the High-Luminosity Large Hadron Collider (HL-LHC) for searches of new particles decaying to two jets. We discuss inclusive searches in dijets and b-jets, as well as searches in semi-inclusive events by requiring an additional lepton that increases sensitivity to different aspects of the underlying processes. We discuss the expected exclusion limits for generic models predicting new massive particles that result in resonant structures in the dijet mass. Prospects of the Higher-Energy LHC (HE-LHC) collider are also discussed. The study is based on the Pythia8 Monte Carlo generator using representative event statistics for the HL-LHC and HE-LHC running conditions. The event samples were created using supercomputers at NERSC.Comment: 27 pages, 19 figure

    Conflicting interests in the pathogen-host tug of war : fungal micronutrient scavenging versus mammalian nutritional immunity

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    Funding: The authors are supported by the European Research Council (STRIFE project funded on grant number ERC-2009-AdG-249793, http://erc.europa.eu). AJPB is also supported by the Wellcome Trust (grant numbers 080088, 097377, www.wellcome.ac.uk) and the UK Biotechnology and Biological Sciences Research Council (grant number BB/F00513X/1, www.bbsrc.ac.uk). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

    A closer look at ARSA activity in a patient with metachromatic leukodystrophy.

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    Metachromatic leukodystrophy (MLD) is an autosomal recessive lysosomal storage disease mainly caused by a deficiency of arylsulfatase A activity. The typical clinical course of patients with the late infantile form includes a regression in motor skills with progression to dysphagia, seizures, hypotonia and death. We present a case of a 4-year-old female with rapidly progressive developmental regression with loss of motor milestones, spasticity and dysphagia. MRI showed volume loss and markedly abnormal deep white matter. Enzymatic testing in one laboratory showed arylsulfatase A activity in their normal range. However, extraction of urine showed a large increase in sulfatide excretion in a second laboratory. Measurement of arylsulfatase A in that laboratory showed a partial decrease in arylsulfatase A activity measured under typical conditions (about 37% of the normal mean). When the concentration of substrate in the assay was lowered to one quarter of that normally used, this individual had activity \u3c10% of controls. The patient was found to be homozygous for an unusual missense mutation in the arylsulfatase A gene confirming the diagnosis of MLD. This case illustrates the importance of careful biochemical and molecular testing for MLD if there is suspicion of this diagnosis

    Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections

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    This work was supported by the European Research Council (http://erc.europa.eu/: STRIFE Advanced Grant ERC-2009-AdG-249793). A.J.P.B. was also supported by the UK Biotechnology and Biological Research Council (www.bbsrc.ac.uk: Research Grants BB/F00513X/1, BB/K017365/1), the UK Medical Research Council (www.mrc.ac.uk: Programme Grant MR/M026663/1; Centre Grant MR/ N006364/1), and the Wellcome Trust (www.wellcome.ac.uk: Strategic Award 097377)Peer reviewedPublisher PD

    Sense Yo Soles

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    The Sense Yo Soles project is a system that is embedded into a shoe insert; the plantar pressure distribution is measured by calculating the ratio of pressure on 6 individual pressure sensors located on the lateral, medial, and heel areas of both the left and right foot to the total pressure distributed across both feet. The alpha prototype created by our client and her Biomedical Engineering senior project team at San Jose State University, measured and analyzed data using the above method while connected to power and a computer. In CPE 350, we made the system stand alone and wireless allowing for the product to be more usable, and reduced the overall cost of the system. We achieved 2 this by using an ATtiny84 microcontroller to control these peripherals and to send data wirelessly using Bluetooth to an external device for processing. In CPE 450, we ported the Java application to an Android application, implemented sleep cycles with interrupts for power management, and implemented a dual sensor communication, allowing 2 sensors to send data to a single Android device. Our main goals for CPE 461/462 were to use Bluetooth Low Energy for power management, to display standing and stride data in a user friendly way on an iOS application, and to package hardware into the insole

    New Clox Systems for rapid and efficient gene disruption in Candida albicans

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    Acknowledgements: We are grateful to Janet Quinn, Lila Kastora, Joanna Potrykus, Michelle Leach, and others for sharing their experiences with the Clox cassettes. We thank Julia Kohler for her kind gift of the NAT1-flipper plasmid pJK863, Claudia Jacob for her advice with In-fusion cloning, and our colleagues in the Aberdeen Fungal Group for numerous stimulating discussions. Data Availability: The authors confirm that all data underlying the findings are fully available without restriction. The sequences of all Clox cassettes are available in GenBank: URA3-Clox (loxP-URA3-MET3p-cre-loxP): GenBank accession number KC999858. NAT1-Clox (loxP-NAT1-MET3p-cre-loxP): GenBank accession number KC999859. LAL (loxP-ARG4-loxP): GenBank accession number DQ015897. LHL (loxP-HIS1-loxP): GenBank accession number DQ015898. LUL (loxP-URA3-loxP): GenBank accession number DQ015899. Funding: This work was supported by the Wellcome Trust (www.wellcome.ac.uk): S.S., F.C.O., N.A.R.G., A.J.P.B. (080088); N.A.R.G., A.J.P.B. (097377). The authors also received support from the European Research Council [http://erc.europa.eu/]: DSC. ERB, AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The European Commission also provided funding [http://ec.europa.eu/research/fp7]: I.B., A.J.P.B. (FINSysB MC-ITN; PITN-GA-2008-214004). Also the UK Biotechnology and Biological Research Council provided support [www.bbsrc.ac.uk]: N.A.R.G., A.J.P.B. (Research Grant; BB/F00513X/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

    Nine Things Genomics Can Tell Us About Candida auris

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    FUNDING RF was supported by MRC grant MR/N006364/2 and a Wellcome Trust Seed Award (215239/Z/19/Z). ACKNOWLEDGMENTS We would like to give thanks to Carolina Coelho for helpful discussions and assistance with Figure 1 and Jose Muñoz for valuable feedback on the manuscript.Peer reviewedPublisher PD

    Defining soil type and habitat characteristics of the Arctomecon Californica

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    A. californica can be considered a rare endemic species, which is believed to be restricted by unique soil relationships. These relationships make the species vulnerable to anthropogenic habitat disturbance. Although A. californica is listed as critically endangered by the state of Nevada, further research is needed before the species can be listed as federally endangered or threatened. This study used primary observational data and secondary GIS compatible data to characterize A. californica habitat. Representative sampling techniques were used to select observations from derived soil types. Although a majority of A. californica populations were found to occur in gypsic soil types, 34.6% were found to occur in limestone soils. This result contradicts previous research, which has characterized A. californica as a gypsic obligate species. Primary observations were analyzed using the full dataset of 2,575 observations. Cryptogam cover, aspect and elevation were all found to be significantly related to A. californica relative abundance. It was also discovered that 96% of A. californica populations occur at elevations close to 600 meters. This study needs to be reinforced by on the ground field research and its main goal is to provide future studies with a foundation for further research
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