An Efficient and Epimerization Free Synthesis of C-Terminal Arylamides Derived from α-Amino Acids and Peptide Acids via T3p Activation

A high yield and rapid synthesis of enantiomerically pure N α -protected amino/peptide acid arylamides using n-propylphosphonic anhydride (T3P) in presence of N-methylmorpholine is described. The generality of the reaction has been studied for various N α -protected amino acids with diverse range of aromatic amines and coumarin derivatives

Synthesis of <i style="mso-bidi-font-style:normal">N^α</i>-Z protected amino alkyl triazole acids and their application to neo-glycopeptides synthesis

858-864The synthesis of triazole linked glycopeptides employing 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) mediated coupling of Z-protected triazole acids with glycosyl amines and amino acid esters is described. The coupling proceeded smoothly at room temperature and the products are obtained in good yields. Z-Protected triazole acids have been synthesized via click chemistry protocol through the cycloaddition of Z-protected alkyl azides with propiolic acid