The colours of comfort:From thermal sensation to person-centric thermal zones for adaptive building strategies

Thermal comfort research has been traditionally based on cross-sectional studies and spatial aggregation of individual surveys at building level. This research design is susceptible to compositional effects and may lead to error in identifying predictors to thermal comfort indices, in particular in relation to adaptive mechanisms. A relationship between comfort and different predictors can be true at an individual level but not evident at the building level. In addition, cross-sectional studies overlook temporal changes in individual thermal perception due to contextual factors. To address these limitations, this study applied a longitudinal research design over 8 to 21 months in eight buildings located in six countries around the world. The dataset comprises of 5,567 individual thermal comfort surveys from 258 participants. The analysis aggregated survey responses at participant level and clustered participants according to their thermal sensation votes (TSV). Four TSV clusters were introduced, representing four different thermal sensation traits. Further analysis reviewed the probability of cluster membership in relation to demographic characteristics and behavioural adaptation. Finally, the analysis at individual level enabled the introduction of a new metric, the thermal zone (Zt), which in this study ranges from 21.5°C to 26.6°C. The thermal sensation traits and person-centric thermal zone (Zt) are a first step into the development of new metrics incorporating individual perceived comfort into dynamic building controls for adaptive buildings

Non-Targeted Metabolomics Investigation of a Sub-Chronic Variable Stress Model Unveils Sex-Dependent Metabolic Differences Induced by Stress

Depression is twice as prevalent in women as in men, however, most preclinical studies of depression have used male rodent models. This study aimed to examine how stress affects metabolic profiles depending on sex using a rodent depression model: sub-chronic variable stress (SCVS). The SCVS model of male and female mice was established in discovery and validation sets. The stress-induced behavioral phenotypic changes were similar in both sexes, however, the metabolic profiles of female plasma and brain became substantially different after stress, whereas those of males did not. Four stress-differential plasma metabolites—β-hydroxybutyric acid (BHB), L-serine, glycerol, and myo-inositol—could yield biomarker panels with excellent performance to discern the stressed individuals only for females. Disturbances in BHB, glucose, 1,5-anhydrosorbitol, lactic acid, and several fatty acids in the plasma of stressed females implied a systemic metabolic shift to β-oxidation in females. The plasma levels of BHB and corticosterone only in stressed females were observed not only in SCVS but also in an acute stress model. These results collectively suggest a sex difference in the metabolic responses by stress, possibly involving the energy metabolism shift to β-oxidation and the HPA axis dysregulation in females