Idiopathic granulomatous mastitis associated with risperidone-induced hyperprolactinemia

Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease. The etiology and treatment options of IGM remain controversial. Previous case reports have suggested that hyperprolactinemia may be associated with IGM. In the present report, we describe the first case of IGM associated with risperidone-induced hyperprolactinemia

Combining Coauthorship Network and Content for Literature Recommendation

This paper studies literature recommendation approaches using both content features and coauthorship relations of articles in literature databases. Most literature databases allow data access (via site subscription) without having to identify users, and thus task-focused recommendation is more appropriate in this context. Previous work mostly utilizes content and usage log for making task-focused recommendation. More recent works start to incorporate coauthorship network for recommendation and found it beneficial when the specified articles preferred by authors are similar in their content. However, it was also found that recommendation based on content features achieves better performance under other circumstances. Therefore, in this work we propose to incorporate both content and coauthorship network in making task-focused recommendation. Three hybrid methods, namely switching, proportional, and fusion are developed and compared. Our experimental results show that in general the proposed hybrid approach achieves better performance than approaches that utilize only one source of knowledge. In particular, the fusion method tends to have higher recommendation accuracy for articles of higher ranks. Besides, the content-based approach is more likely to recommend articles of low fidelity, whereas the coauthorship network-based approach has the least chance

Synergism of Rana catesbeiana ribonuclease and IFN-γ triggers distinct death machineries in different human cancer cells

AbstractRana catesbeiana ribonuclease (RC-RNase) possesses tumor-specific cytotoxicity, which can be synergized by IFN-γ. However, it is unclear how RC-RNase and RC-RNase/IFN-γ induce cell death. In this study, we use substrate cleavage assays to systematically investigate RC-RNase- and RC-RNase/IFN-γ-induced caspase activation in HL-60, MCF-7, and SK-Hep-1 cells. We find that RC-RNase and RC-RNase/IFN-γ induce mitochondria-mediated caspase activation in HL-60 and MCF-7 cells but not in SK-Hep-1 cells, although death of SK-Hep-1 cells is closely related to mitochondrial disruptions. Our findings provide evidence that RC-RNase and RC-RNase/IFN-γ can kill different cancer cells by distinct mechanisms. Compared with onconase, RC-RNase seems to harbor a more specific anti-cancer activity

Integrin-mediated membrane blebbing is dependent on the NHE1 and NCX1 activities.

Integrin-mediated signal transduction and membrane blebbing have been well studied to modulate cell adhesion, spreading and migration^1-6^. However, the relationship between membrane blebbing and integrin signaling has not been explored. Here we show that integrin-ligand interaction induces membrane blebbing and membrane permeability change. We found that sodium-proton exchanger 1 (NHE1) and sodium-calcium exchanger 1 (NCX1) are located in the membrane blebbing sites and inhibition of NHE1 disrupts membrane blebbing and decreases membrane permeability change. However, inhibition of NCX1 enhances cell blebbing to cause cell swelling which is correlated with an intracellular sodium accumulation induced by NHE17. These data suggest that sodium influx induced by NHE1 is a driving force for membrane blebbing growth, while sodium efflux induced by NCX1 in a reverse mode causes membrane blebbing retraction. Together, these data reveal a novel function of NHE1 and NCX1 in membrane permeability change and blebbing and provide the link for integrin signaling and membrane blebbing