MOESM1 of Passive targeting of thermosensitive diblock copolymer micelles to the lungs: synthesis and characterization of poly(N-isopropylacrylamide)-block-poly(Îľ-caprolactone)

Additional file 1. Physicochemical characterization of PNiPAAm-b-PCL micelles and the carboplatin accumulation (Îźg/mg) in organs after intravenous administration of solution vehicle and PNiPAAm8-b-PCL20 micelles

Additional file 2: Figure S2. of Epidermal growth factor receptor inhibitor with fluorouracil, leucovorin, and irinotecan as an alternative treatment for advanced upper tract urothelial carcinoma: a case report

Electropherogram of the telomerase reverse transcriptase (TERT) promoter region. (TIF 3855 kb

Additional file 3: Figure S3. of Epidermal growth factor receptor inhibitor with fluorouracil, leucovorin, and irinotecan as an alternative treatment for advanced upper tract urothelial carcinoma: a case report

Electropherogram of exon 2 of the KRAS gene. (TIF 3851 kb

Additional file 1: Figure S1. of Epidermal growth factor receptor inhibitor with fluorouracil, leucovorin, and irinotecan as an alternative treatment for advanced upper tract urothelial carcinoma: a case report

(A) Photomicrograph of the rectum showed the presence of neoplastic cells resembling adenocarcinoma (arrow). (B) Microscopic features of renal pelvis revealed infiltrating urothelial carcinoma, high grade (arrow). (C) Microscopic features of ureter revealed infiltrating urothelial carcinoma, high grade (arrow). (D) Microscopic features of bladder revealed infiltrating urothelial carcinoma, high grade (arrow). A–D show hematoxylin and eosin stain, magnification ×200. (TIF 2307 kb

Kaplan-Meier estimates of 5-year outcome in the segmental mandibulectomy patients stratified by level IV/V metastases, extracapsular spread status and tumor depth of ≥15 mm, (a) local control, (b) neck control, (c) distant metastases, (d) disease-free survival, (e) disease-specific survival, (f) overall survival.

<p>Kaplan-Meier estimates of 5-year outcome in the segmental mandibulectomy patients stratified by level IV/V metastases, extracapsular spread status and tumor depth of ≥15 mm, (a) local control, (b) neck control, (c) distant metastases, (d) disease-free survival, (e) disease-specific survival, (f) overall survival.</p

Multivariate analysis of 5-year outcomes in patients treated by segmental mandibulectomy (n = 310).

<p>HR: hazard ratio; CI: confidence interval; ns: not significant.</p>a<p>All of the factors identified in univariate analysis were entered into the multivariate analyses; only significant factors were listed in this table.</p

The clinicopathological characteristics of OSCC patients treated by segmental mandibulectomy.

<p>S, surgery; RT, radiotherapy; CCRT, concurrent chemoradiotherapy.</p>a<p>Unavailable data: pN status (n = 1), margin (n = 3), perineural invasion (n = 1), vascular invasion (n = 1), lymphatic invasion (n = 1).</p>b<p>Patient who did not receive neck dissection (n = 1) was classified as pN0.</p>c<p>Optimal cut-off value for disease-free survival.</p>d<p>Tumor depth was defined as the measured thickness from the surface of the normal mucosa to the deepest portion of the tumor.</p

Treatment decision tree for fibular reconstruction.

<p>Treatment decision tree for fibular reconstruction.</p

Stepwise multiple regression for determinants of QTc dispersion in type 2 diabetic patients.

<p>*Multiple linear regressions using stepwise selection was performed with a default entry significance level of 0.15 and an exit significance level of 0.15. eGFR, estimated glomerular filtration rate</p><p>Stepwise multiple regression for determinants of QTc dispersion in type 2 diabetic patients.</p

Baseline characteristics of study participants.

<p>*Smoking status was classified as “never smokers”, “ex-smokers”, “current smokers with less than 10 cigarettes daily”, and “current smokers with more than 10 cigarettes daily” and are coded as ordinal variables.</p><p>**Alcohol use was classified as “less than 2–3 times annually”, “2–3 times monthly” “2–3times weekly”, and “more than 3 times weekly” using questionnaires and are coded as ordinal variables.</p><p>SI-QTc, smoothness index of QTc; HbA1c, hemoglobin A1c; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; ACR, albumin-creatinine ratio; eGFR, estimated glomerular filtration rate; ARB: angiogtensin II receptor blocker; ACE, angiotensin converting enzyme</p><p>Baseline characteristics of study participants.</p