UNC health system hospitals that participated in the CCP EAP and EUA.

(TIFF)</p

CCP recipient and non-recipient characteristics.

CCP recipient and non-recipient characteristics.</p

CCP recipient characteristics.

CCP recipient characteristics.</p

Comparisons of recipient factors of time from admission to CCP infusion of EAP participants at UNCMC.

(A) those that were consented in English vs those that required use of a Spanish interpreter, (B) sex, (C) race, (D) ethnicity, (E) age, and (F) blood type. Medians are reported. P values obtained via a non-parametric Mann-Whitney U test. (TIF)</p

Proportions and cumulative titered units collected and transfused during the EAP era at UNCMC.

(A) Monthly proportions of low (gray) versus standard (blue) versus high (black) titered units collected. Percentages at tops of bars are cumulative proportions of standard + high titered units. (B) Monthly proportions of low (gray) versus standard (blue) versus high (black) titered units transfused. Percentages at tops of bars are cumulative proportions of standard + high titered units. (C) Cumulative total units collected and transfused over time, cumulative units with titers ≥1:160 collected and transfused over time, cumulative national supplier units transfused over time.</p

CCP administration process schematic.

Steps, eligibility criteria, and personnel involved in administering COVID-19 Convalescent Plasma (CCP) in the inpatient setting at The University of North Carolina Medical Center (UNCMC). The major process events of admission, enrollment, and infusion depicted in Fig 1 are scaled proportionally to the median time intervals spent on these activities at UNCMC. EAP = expanded access program, PCR = polymerase chain reaction, RCT = randomized controlled trial, GI = gastrointestinal, ICU = intensive care unit, ID = infectious diseases, MD = medical doctor, APP = advanced practice provider, RN = registered nurse, NP = nurse practitioner, QC = quality control.</p

Time from admission to CCP infusion of EAP and EUA recipients at UNCMC and affiliates.

Medians are reported. P values obtained via a non-parametric Mann-Whitney U test. (TIF)</p

Time to CCP infusion comparisons.

(A) Time from admission to CCP infusion of recipients in the UNCMC EAP (blue circles) versus affiliates EAP (black squares) versus affiliates EUA (grey inverted triangles). (B) Time from admission to enrollment, enrollment to CCP infusion and admission to CCP infusion for recipients in the UNCMC EAP comparing those that received CCP units from the UNCMC Blood Donation Center (dark blue open circles) versus a national vendor (light blue open squares). (C) Time from admission to CCP infusion for type of EAP consent obtained at UNCMC (participant consent in light blue circles, LAR consent in dark blue circles, 2MD in open squares). (D) During the CCP EAP era at UNCMC, first comparison is time from admission to remdesivir for all who received remdesivir (dark blue open circles) versus time from admission to CCP infusion of EAP participants (middle blue circles); second comparison is time from admission to remdesivir for all who received remdesivir and CCP (light blue open squares) versus those who received only remdesivir (black open triangles). (E) During the CCP EAP era at UNCMC, time from admission to remdesivir: first comparison is between those that received remdesivir in the ICU (middle blue circles) versus non-ICU (dark blue squares); second comparison is between those that received remdesivir and CCP (middle blue open circles) versus only remdesivir in the non-ICU (dark blue open squares); third comparison is between those that received remdesivir and CCP (middle blue circles) versus only remdesivir in the ICU (dark blue squares). Medians are reported. P values obtained via a non-parametric Mann-Whitney U test.</p

Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) constructs.

Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) constructs.</p

Time to CCP infusion comparisons.

(A). Time from admission to enrollment, enrollment to CCP infusion and admission to CCP infusion via the EAP at UNCMC in the ICU (blue open circles) versus the non-ICU (black open squares). (B) Time from admission to CCP infusion via the EAP at UNCMC for those admitted during the day shift (7am-7pm) (middle blue open squares) versus the night shift (7pm-7am) (dark blue squares). Medians are reported. P values obtained via a non-parametric Mann-Whitney U test.</p