Association between adherence measures and viral load.

<p>Association between adherence measures and viral load.</p

Zambia Map No.

<p>Zambia Map No.</p

Factors associated with abandonment or non-initiation of treatment: Proximate residence, HIV status, and maternal education as predictors in a multivariable model.

<p>N = 162.</p

Predictors of the number of non-adherent days per quarter.

<p>IRR – Incidence rate ratio, all factors time updated except for sex.</p>a.<p> Overall p-value for age and sex.</p>b.<p> P-value for interaction between age and sex.</p

Factors Associated with Abandonment of Treatment (Unadjusted Analysis). Residence, HIV status and maternal education used in model.

<p>Factors Associated with Abandonment of Treatment (Unadjusted Analysis). Residence, HIV status and maternal education used in model.</p

Consort Diagram.

<p>Consort Diagram.</p

Cohort Characteristics for 162 children with cancer seen at the University Teaching Hospital, Lusaka, Zambia^*.

<p>*For selected sociodemographic characteristics, sample size is <162 due to missing data. P-values calculated by Kruskal-Wallis test for continuous variables (age, time of symptoms) or Chi-square/Fisher’s exact tests (categorical variables) as appropriate. P-values for all categorical comparisons compare children whose cancer treatment was active at the time of the study or was completed vs. children died during therapy vs. abandoned treatment.</p

Characteristics at ART initiation.

a.<p> Other statistics are indicated in the second column.</p>b.<p> UK 1990 growth reference; WHO 2007 reference only available to 10 years. For children to age 10, the average UK weight Z-score was 0.5 lower than the WHO reference and the average UK height Z-score was 0.1 higher than WHO reference.</p>c.<p> Missing data for one child.</p

Follow-up, summary of adherence measures and agreement between methods.

a.<p> Percentage of follow-up visits with no missed dose reported during previous month.</p>b.<p> Agreement between the last missed dose question and other methods should be interpreted separately (e.g. 90% adherent for the last missed dose means that no treatment was missed in nine periods out of ten, but does not indicate the level of non-adherence in those periods).</p

Agreement between measures (as shown by the difference between methods versus mean adherence value for each child).

<p>The Bland-Altman plots in this figure show pair wise agreement between adherence methods. Each plot indicates the difference between two methods on the vertical axis against the mean of the same methods on the horizontal axis. Data points above the zero line occur when the first method shows higher adherence than the second. On the horizontal axis, data points to the right indicate high adherence from both methods, in which case the maximum possible difference between them is shown by the angled lines.</p