Measurements in eyes with central retinal vein occlusion at baseline and at 1 month and 6 months after initial treatment.

<p>Measurements in eyes with central retinal vein occlusion at baseline and at 1 month and 6 months after initial treatment.</p

Association between Age and Oxygen Saturation in Major Retinal Vessels Measured by Oxymap T1.

<p>Association between Age and Oxygen Saturation in Major Retinal Vessels Measured by Oxymap T1.</p

Retinal Oximetry in a Healthy Japanese Population

<div><p>Purpose</p><p>To establish the normative database of retinal oximetry using Oxymap T1 in a healthy Japanese population, and study the reproducibility of the measurements in Japanese.</p><p>Methods</p><p>We measured oxygen saturation in the major retinal vessels with Oxymap T1 in 252 eyes of 252 healthy Japanese subjects. Fundus images acquired using Oxymap T1 were processed using built-in Oxymap Analyzer software. Reproducibility of retinal oximetry was investigated using 20 eyes of 20 healthy subjects.</p><p>Results</p><p>The mean retinal oxygen saturation of 4 quadrants in healthy Japanese was 97.0 ± 6.9% in arteries and 52.8 ± 8.3% in veins. The mean arteriovenous difference in oxygen saturation was 44.2 ± 9.2%. Both arterial and venous oxygen saturation were significantly lower in the temporal side of the retina, especially in the temporal-inferior vessels. However, the arteriovenous difference in oxygen saturation was limited in the 4 quadrants. Interphotograph, intervisit, and interevaluator intraclass correlation coefficients were 0.936–0.979, 0.809–0.837, and 0.732–0.947, respectively. In the major retinal arteries, oxygen saturation increased with age (r = 0.18, p<0.01), at a rate of 0.67% per 10 years. However, venous oxygen saturation showed no correlation with age.</p><p>Conclusions</p><p>This study provides the normative database for the Japanese population. The arterial saturation value appears to be higher than other previous studies. Mean retinal oximetry in 4 quadrants with Oxymap T1 has high reproducibility.</p></div

Quantitative measurements of retinal morphologic changes associated with acute central retinal vein occlusion using optical coherence tomography.

<p>On the horizontal and vertical sections through the foveal center, the inner (blue arrows), outer (yellow arrows), and total (red arrows) retinal thickness was measured at 0.5 mm, 1.0 mm, and 1.5 mm from the center of the fovea towards both sides of the retina, respectively. The maximum thickness of the inner, outer, or total retina was determined as the largest of the 12 measurements (white dot). The total foveal thickness was defined as the distance between the vitreoretinal interface and the inner surface of the retinal pigment epithelium (black dot).</p

Oxygen Saturation in Major Retinal Vessels in a Healthy Japanese Population Measured by Oxymap T1.

<p>Oxygen Saturation in Major Retinal Vessels in a Healthy Japanese Population Measured by Oxymap T1.</p

Association between retinal oxygen saturation and age in healthy Japanese.

<p>(<b>A</b>) Mean oxygen saturation in major retinal arteries in 4 quadrants (r = 0.18, p<0.01). (<b>B</b>) Mean oxygen saturation in major retinal veins in 4 quadrants (r = -0.06). (<b>C</b>) Mean arteriovenous (A-V) difference in mean oxygen saturation in 4 quadrants (r = 0.19, p<0.01).</p

Baseline Characteristics of Eyes with Acute Branch Retinal Vein Occlusion.

<p>Baseline Characteristics of Eyes with Acute Branch Retinal Vein Occlusion.</p

Subgroup analysis of correlation between response to treatment and M-CHARTS scores in patients with ischemic CRVO and patients with non-ischemic CRVO.

<p>Subgroup analysis of correlation between response to treatment and M-CHARTS scores in patients with ischemic CRVO and patients with non-ischemic CRVO.</p

Fundus images at two different wavelengths of light obtained by Oxymap T1 and the oxygen saturation map analyzed by Oxymap Analyzer.

<p>(<b>A</b>, <b>B</b>) Oxymap T1 simultaneously captures 50° monochrome images centered at the optic disc at two different wavelengths of light (570 nm and 600 nm). (<b>A</b>) 570 nm is the reference isosbestic wavelength that is insensitive to oxygen concentration. (<b>B</b>) 600 nm is the oxygen-sensitive wavelength. (<b>C</b>) Oxymap Analyzer automatically calculates the oxygen saturation in each selected vessel and produces a color oxygen saturation map. Retinal vessels with higher oxygen saturation are indicated with red to orange color. Green to purple color indicates the retinal vessels with lower oxygen saturation. (<b>D</b>) For the analysis, vessel selection was performed disc-centered, 1.5-to 3-disc diameters area and 1 disc diameter away from the disc margin.</p

Correlations between the baseline and the posttreatment total foveal thickness (A), maximum outer retinal thickness (B), visual acuity (C), and M-CHARTS score (D) in eyes with acute branch retinal vein occlusion that were treated with an intravitreal injection of ranibizumab.

<p>One month after the initial treatment, the maximum outer retinal thickness and total foveal thickness and was significantly decreased (both p < 0.001). The visual acuity in logMAR was also significantly improved (p < 0.001). The improvement in the mean M-CHARTS score was not significant (p = 0.050), and 28 eyes still had metamorphopsia.</p