Statistical analysis of significance between fiscal years using Ryan’s multiple comparisons for the number of myringotomies performed before and after introduction of the free heptavalent pneumococcal conjugate vaccine.

<p>^# nominal level of significance.</p><p>Statistical analysis of significance between fiscal years using Ryan’s multiple comparisons for the number of myringotomies performed before and after introduction of the free heptavalent pneumococcal conjugate vaccine.</p

Comparison of clinical practice guidelines for the diagnosis and management of AOM in children in Japan in 2006, with revisions published in 2009 [11] and 2013 [12].

<p>The main difference between the first and second guidelines is the recommendation for duration of antimicrobial use. All guidelines recommend myringotomy for all AOM with severe otoscopic findings. The first and second guidelines recommend second myringotomy for all treatment-resistant AOM, and the third recommends myringotomy on a case-by case basis. Indications for myringotomy are the same in the first and second editions.</p><p>Comparison of clinical practice guidelines for the diagnosis and management of AOM in children in Japan in 2006, with revisions published in 2009 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137546#pone.0137546.ref011" target="_blank">11</a>] and 2013 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137546#pone.0137546.ref012" target="_blank">12</a>].</p

Rate of myringotomy for acute otitis media per 1,000 population-years in age groups, according to year.

<p>Public funding for PCV7 was introduced in January 2011.</p

Seasonal changes in rate of myringotomy for acute otitis media per 1,000 population according to year.

<p>Public funding for PCV7 was introduced in January 2011.</p

Rate of the number of reports per fixed point of influenza as ratio per 1 million population according to year from Hiroshima City Infectious Disease Surveillance Center.

<p>Public funding for PCV7 was introduced in January 2011.</p