Relationship between Drainage Basin Characteristics and Riverine Landscape on an Alluvial Fan

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Genetic adaptive mechanisms mediating response and tolerance to acetic acid stress in the human pathogen Candida glabrata: role of the CgHaa1-dependent signaling pathway

The increased resilience of Candida glabrata to azoles and the continuous emergence of strains resistant to other antifungals demands the development of new therapeutic approaches focused on non-conventional biological targets. Genes contributing to increase C. glabrata competitiveness in the different infection sites are an interesting and unexplored cohort of therapeutic targets. To thrive in the vaginal tract and avoid exclusion C. glabrata cells have evolved dedicated responses rendering them capable of tolerating multiple environmental challenges, including the presence of acetic and lactic acids produced by the commensal microbiota. In this work a cohort of vaginal clinical isolates were phenotyped for their tolerance to acetic acid stress at a low pH as well as for several traits that are known to influence sensitivity to this organic acid, including the structure of the cell envelope and the ability to consume the acid in the presence of glucose. The role played by the ORF CAGL0L09339g, an homologue of the ScHaa1, a critical regulator of acetic acid resistance in S. cerevisiae[1], in C. glabrata response and tolerance to acetic acid stress at pH 4 was also scrutinized using a transcriptomic analysis. The role of CgHaa1 as well as of several of its target genes in mediating virulence of C. glabrata against epithelial vaginal cells was also studied.Funding received by the Institute for Bioengineering and Biosciences from the Portuguese Foundation for Science and Technology (FCT) (UID/BIO/04565/2013) and from Programa Operacional Regional de Lisboa 2020 (project no. 007317) is acknowledged. FCT is also acknowledged for funding the Centre of Biological Engineering through contracts FCOMP-01-0124-FEDER- 020243 and PTDC/EBB-EBI/120495/2010info:eu-repo/semantics/publishedVersio

Recreational Spaces for the Visually-Handicapped Part 2: Evaluation of Shops on a Guided Bus Tour

It is important to create and modify the environments in which the visually-handicapped can go shopping easily and enjoyably. This study is based on "taking part in a guided bus tour", and we investigate whether they can indeed enjoy shopping in the facilities visited. The guided bus tour takes one whole day, during which they visit five facilities -an aquarium, a multi-purpose dome, a castle, a water bus and a sky observation deck. All these facilities have some shops, except for the water bus.ARCHITECTURE, 50th anniversary editio

Walking Environments for the Visually-Handicapped : Recognition of Spaces in a Geometric Model Laboratory

In daily life it is not safe for visually-handicapped people to walk alone and often they have accidents or lose their way. In order to improve walking environments, it is important to show clearly how visually-handicapped people recognize spaces and their position in spaces, and what the clues to recognition are. In this study, in order to clarify the characteristics of search behavior, experiments are carried out in 12 kinds of model spaces of geometric plan. The behavior of the visually-handicapped is analyzed by walking locus, and the recognition of spaces, by sketch map and interview

Recreational Spaces for the Visually-Handicapped : Taking Part in a Guided Bus Tour

It is important that visually-handicapped people can adapt themselves to contemporary society, operate freely and enjoy leisure as much as normal-sighted people can. This is a case study on enjoying leisure and recreational spaces for the visually-handicapped. The visually-handicapped take part in a guided bus tour, and we investigate whether they can enjoy the bus ride and the facilities visited. The guided bus tour takes one whole day during which they visit five facilities-an aquarium, a multi-purpose dome, a castle, a water bus and a sky observation deck

Estimativa da massa e volume de frutos de café usando métodos não destrutivos.

A avaliação do crescimento dos frutos do café é, normalmente, feita por coleta do fruto, inviabilizando a avaliação continua do mesmo fruto durante toda sua maturação. O objetivo deste trabalho foi estabelecer métodos não destrutivos, baseados em modelos de regressão, para estimar massas seca e fresca e volume de frutos de café a partir de medidas dos comprimentos longitudinal e transversal do fruto. O estudo foi conduzido em cafezal da cultivar IAPAR 59, sem irrigação, instalado na Estação Experimental do IAPAR em Londrina, PR. Foram tomadas as medidas de maior diâmetro longitudinal (comprimento), maior e menor diâmetro transversal (largura), volume, massa fresca e massa seca de frutos em diferentes estádios de desenvolvimento, e analisadas as correlações entre elas. Concluiu-se que as massas fresca e seca e o volume dos frutos podem ser estimados de forma eficiente e não destrutiva a partir de medidas de comprimento e largura