3 research outputs found
Chiral sulfoxides in the enantioselective allylation of aldehydes with allyltrichlorosilane: a kinetic study
The mechanism of the allylation of aldehydes in the presence of allyltrichlorosilane employing the
commercially available (R)-methyl p-tolyl sulfoxide as a Lewis base has been investigated. The combination
of kinetic measurements, conductivity analysis and quantum chemical calculations indicates that the reaction
proceeds through a dissociative pathway in which an octahedral cationic complex with two sulfoxides is
involved. The lack of turnover is ascribed to the formation of neutral sulfurane derivatives
Combined electrochemical/chemical methods for the synthesis and the molecular diversifying of isoindolinone-based heterocyclic scaffolds
By means of C–H acids activation on Pt-cathode,
an electrochemically initiated strategy aimed to developing
a diversity-oriented synthesis based on the isoindolinone
nucleus has been established. Conveniently, the achievement
of a small library of new heterocycle-fused isoindolinone
compounds with potential interest for drug design was carried
out by using tandem reactions and one-pot sequential
processes
Organocatalysts and sequential asymmetric cascade reactions in the synthesis of functionalized isoindolinones and benzoindolizidinones
In this article we have disclosed a combination of versatile methodologies for the asymmetric synthesis and
manipulation of isoindolinones and fused benzo-indolizidinones. On one hand, two consecutive
asymmetric cascade reactions allow the synthesis of isoindolinones and fused benzo-indolizidinones,
with the stereoselective construction of up to three stereocenters. On the other hand the study of the
heterochiral crystallization and the easy functionalization of the obtained molecular platforms render the
chemistry of these heterocyclic compounds particularly useful