Anthropometric and kinematic data.

<p>Anthropometric and kinematic data.</p

Modulation of the spectral power during the gait cycle.

<p>Event related synchronization (ERS) and desynchronization (ERD) in low <i>β-</i> (top) high <i>β-</i> (middle) and <i>γ</i>-frequency band (bottom). Subthalamic power changes of the phases of gait are shown as the average relative change of the whole stride of all subjects. Shaded areas represent the confidence intervals (5–95%) of the group mean. We analyzed the power changes of STN–and STN+ during the gait cycle of the contralateral foot (but they could be also referred to the matched gait phases of the ipsilateral one). Stance is the period during which the foot is on the ground (dark and light orange bars). The stance phase includes a period of bilateral foot contact with the floor (double-support phases [dark orange bars]), and a period of unilateral foot contact (single-support phase [light orange bar]). The swing phase (light green and dark green bars) is the interval in which the foot is lifted from the floor. Thanks to the velocity peak (VP) of the marker placed on the lateral malleolus, we identified an acceleration (light green) a deceleration (dark green) sub-phase of the swing phase. HS = heel strike; TO = toe off; VP = velocity peak; lower case subscript indicates the foot contralateral _(contra) or ipsilateral _(ipsi) to STN–or STN+.</p

Inter-hemispheric coherence.

<p>Inter-hemispheric coherence (Coh, top panel), phase locking value (PLV, bottom left plot) and amplitude cross-correlation (CC, bottom right plot) during resting state (blue line), upright standing (pink line) and walking (green line). Statistical significance (red bar, paired Wilcoxon test, <i>p</i><0.05 uncorrected) was reached for the PLV selectively in the <i>β</i>-frequency band between resting state and walking. Shaded areas represent the confidence intervals (5–95%) of the group mean.</p

Non-displaceable binding potentials of dopamine reuptake transporters.

<p>Non-displaceable binding potentials of dopamine reuptake transporters.</p

Spectral profiles (single subject) during resting, upright standing and gait.

<p>Single subject spectral power of the STN local field potential during resting (blue line), standing (pink line) and gait for the two hemispheres, with less (–) and more (+) striatal dopamine innervation. Axial slices are left-right flipped to match the corresponding STN. The peak at 32 Hz is a known artefact of the Activa PC+S^® system tied to clock settings or due to a triggered check of the battery status. SPECT scans (central column) show striatal dopaminergic loss as percentage decline with respect to healthy subjects (calculated from BP_ND of DAT, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0198691#pone.0198691.t003" target="_blank">Table 3</a>).</p

Spectral profiles (average) during resting, upright standing, and gait.

<p>Average spectral power of the STN local field potential during resting (blue line), standing (pink line) and gait (green line) for the two hemispheres, with less (–) and more (+) striatal dopamine innervation. Results are corrected for the nominal noise floor level of the device (150nV/rtHz, [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0198691#pone.0198691.ref032" target="_blank">32</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0198691#pone.0198691.ref033" target="_blank">33</a>]), all values above 0dB/Hz are reliable. Shaded areas represent the confidence intervals (5–95%) of the group mean. The peak at 32 Hz is a known artefact of the Activa PC+S^® system tied to clock settings or due to a triggered check of the battery status.</p

Clinical data.

<p>Clinical data.</p