Case history : a magnetic and GPR prospection on a Roman rural villa in western Piedmont (Italy )

To explore an archaeological site in western Piedmont we proceed to a multimethod survey using fast methods and taking also into account the information achievable after a 2D or 3D data processing and/or rendering. This choice restricted the methodologies to magnetic and GPR prospecting. The non contact resistance imaging, in our opinion, still gives too smeared results even if indicative of resistivity anomalies. We selected the magnetic prospecting because of the remarkable size of some of the walls actually excavated even if, as we explain in the geological context, the probability of collecting a significant amount of noise was high

Il Giardino Segreto di Adriano Proposta di nuova musealizzazione dei luoghi e dei percorsi all'interno di Villa Adriana

Villa Adriana dal 1999 è entrata a far parte della Lista del Patrimonio Mondiale dell’UNESCO, riconosciuta quale mirabile sintesi della cultura greco-romana. La Villa, pur essendo stata oggetto di studi e disegni per molti secoli, continua a celare luoghi misteriosi e incompresi. L’area anche detta del Giardino Segreto di Adriano è sicuramente uno di questi luoghi, mai entrata a far parte del percorso di visita a causa della presenza di un campeggio realizzato negli anni cinquanta; oggi le archeologie romane e i ruderi del campeggio appaiono come oggetti abbandonati in un conflitto irrisolto. Il progetto propone di ridare forma a questo luogo, attraverso un percorso che presenta la successione degli spazi che componevano il Giardino, ricreando le scenografie ed il rapporto che esisteva fra loro

Reply to: "To close the stable door before the horse has bolted"

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Studying pyrolysis products of bottom-of-the-barrel fuel with Py-GCxGC- TOF/CSD/FID

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Facial dermatoses and use of protective mask during Covid-19 pandemic: A clinical and psychological evaluation in patients affected by moderate-severe atopic dermatitis under treatment with dupilumab

During the SARS-COV-2 pandemic, using face masks became mandatory in many countries. Although evidence suggests that masks can exacerbate several inflammatory skin diseases, few studies focus on their real impact on eczema localized to the face in atopic dermatitis (AD) patients. The aim of this study is to evaluate facial eczema prevalence during pandemic and its psychological impact in AD patients pre-assessed for systemic treatment and/or in therapy with dupilumab. This study includes 71 patients affected by moderate-severe AD, treated with dupilumab at SCDU of Dermatology in Novara, Italy. We calculated the number of subjects with facial involvement in pre- and post-pandemic periods and the related localization trend. We evaluated, in the two groups, clinical and psychological indicators recorded at each visit and the score modifications during the observational period. No statistically significant differences were observed in facial eczema prevalence, between pre- and post-pandemic periods (p = 0.7618) and in facial eczema remission among the two groups (p = 0.1903). In post-pandemic period, psychological scores were significantly lower (DLQI and HADS respectively with p < 0.0001 and p = 0.0025) and the reduction in EASI score during observational period was significantly greater (p = 0.0001). Our analysis revealed a potential protective effect of masks on face eczema, suggesting that they could enhance dupilumab efficacy. Face masks, covering sensitive areas, can positively contribute to mental distress in patients with facial eczema, and being associated with a lower allergic diseases incidence may sustain dupilumab in reducing AD severity

Pulmonary hypertension and chronic lung disease: where are we headed?

Pulmonary hypertension related to chronic lung disease, mainly represented by COPD and idiopathic pulmonary fibrosis, is associated with a worse outcome when compared with patients only affected by parenchymal lung disease. At present, no therapies are available to reverse or slow down the pathological process of this condition and most of the clinical trials conducted to date have had no clinically significant impact. Nevertheless, the importance of chronic lung diseases is always more widely recognised and, along with its increasing incidence, associated pulmonary hypertension is also expected to be growing in frequency and as a health burden worldwide. Therefore, it is desirable to develop useful and reliable tools to obtain an early diagnosis and to monitor and follow-up this condition, while new insights in the therapeutic approach are explored

Comorbidities in idiopathic pulmonary fibrosis: an underestimated issue

Idiopathic pulmonary fibrosis (IPF) is a progressive and fibrosing lung disease with a poor prognosis. Between 60% and 70% of IPF patients die of IPF; the remaining causes of death may be due to comorbidities occurring in this ageing population. Interest in the role played by comorbidities in IPF has increased in the past few years. The optimal clinical management of IPF is multifaceted and not only involves antifibrotic treatment, but also vaccinations, oxygen supplementation, evaluation of nutritional status as well as psychological support and patient education. Symptom management, pulmonary rehabilitation, palliative care and treatment of comorbidities represent further areas of clinical intervention. This review analyses the major comorbidities observed in IPF, focusing on those that have the greatest impact on mortality and quality of life (QoL). The identification and treatment of comorbidities may help to improve patients' health-related QoL (i.e. sleep apnoea and depression), while some comorbidities (i.e. lung cancer, cardiovascular diseases and pulmonary hypertension) influence survival. It has been outlined that gathering comorbidities data improves the prediction of survival beyond the clinical and physiological parameters of IPF