A] strong positive beta-3-tubulin expression versus absence cores B) 2+ beta-3-tubulin expression.

<p>A] strong positive beta-3-tubulin expression versus absence cores B) 2+ beta-3-tubulin expression.</p

Univariate analysis for Event Free Survival (EFS).

<p>vs: versus; G: grade; IHC: immunohistochemistry.</p><p>Univariate analysis for Event Free Survival (EFS).</p

Outcome results according to tumor size and nodal involvement.

<p>DFS: disease free survival; OS: overall survival; yrs: years; n.e.: not evaluable (too few patients).</p><p>Outcome results according to tumor size and nodal involvement.</p

Unudjested Kaplan-Meier curves for Event-free Survival (A) and Overall Survival (B) according to beta-3-tubulin.

<p>Unudjested Kaplan-Meier curves for Event-free Survival (A) and Overall Survival (B) according to beta-3-tubulin.</p

Unudjested Kaplan-Meier curves for Event-free Survival (A) and Overall Survival (B) according to the combination of c-Myc and beta-3-tubulin.

<p>Unudjested Kaplan-Meier curves for Event-free Survival (A) and Overall Survival (B) according to the combination of c-Myc and beta-3-tubulin.</p

Patients’ characteristics, according to clinicopathological and molecular variables.

<p>G: grade; TUR: trans-urethral resection; IHC: immunohistochemistry. Among 46 cancer, 36 showed urothelial, 2 squamous, 2 sarcomatoid, 2 micropapillary, 1 squamo-glandular, 1 small cell, 1 nested, 1 plasmocytoid differentiation.</p><p>Patients’ characteristics, according to clinicopathological and molecular variables.</p

Univariate analysis for Overall Survival (OS).

<p>vs: versus; G: grade; IHC: immunohistochemistry.</p><p>Univariate analysis for Overall Survival (OS).</p

A] c-Myc iperexpression (2+); B] absence of expression of c-Myc.

<p>A] c-Myc iperexpression (2+); B] absence of expression of c-Myc.</p

Association between the presence of CTCs before starting a new line of chemotherapy and response to treatment.

<p>Higher response rate is observed in CTC-negative patients at baseline (A). Dynamic variation of CTCs numbers before and after treatment in patients (n = 10) with at least two determinations and at least one CTC at any time point. CTCs changes did not correlate with tumor response (B).</p

Kaplan-Meier estimates of overall survival according to a combined risk factors model with Argiris factors and CTCs.

<p>Continuous line indicates absence of both risk factors; small dotted line indicates the presence of only one of the two risk factors; large dotted line indicates the presence of both risk factors.</p