TOP-INDUCED ELECTROWEAK BREAKING IN THE MINIMAL SUPERSYMMETRIC STANDARD MODEL

Severe constraints on parameters of the minimal supersymmetric standard model follow from a dynamical electroweak symmetry breaking mechanism dominated by top and stop loops. In particular, the lightest Higgs boson mass is expected to be smaller than 100 GeV.Comment: 10 pages, Latex, 6 Postcript Figure

Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites

Background: During epithelial-to-mesenchymal transition, cancer cells lose adhesion capacity gaining migratory properties. The role of the process on prognosis has been evaluated in 50 cases of laryngeal carcinoma. Methods: E-cadherin, N-cadherin, β-catenin, α-catenin, γ-catenin, caveolin-1, and vimentin immunohistochemical expression were evaluated using a double score based on staining intensity and cellular localization. Results: Cytoplasmic E-cadherin and α/γ catenin staining were associated with a decrease in survival, cytoplasmic β-catenin was associated with advanced stage, and N-cadherin and vimentin expression were associated with poor differentiation and tumor relapse. On the basis of cancer cells, epithelial or mesenchymal morphological and immunophenotypic similarity we identified 4 main subgroups correlated with a transition to a more undifferentiated phenotype, which have a different pattern of relapse and survival. Conclusion: The negative prognostic role of epithelial-to-mesenchymal transition has been confirmed and a predictive role in glottic tumors has been suggested, leading us to propose epithelial-to-mesenchymal transition as an additional adverse feature in laryngeal carcinoma

Top Quark Production in Extended Bess Model

We study top production at Tevatron collider in the extended BESS model, which is an effective lagrangian parametrization of a dynamical symmetry breaking of the electroweak symmetry. The existence of a colored octet of gauge vector bosons can increase top production at a rate still consistent with recent experimental data and lead to distorsions in the transverse momentum spectrum of the top.Comment: 13 pages, LaTeX, 4 figure

KMT2C modulates migration and invasion processes in osteosarcoma cell lines

In this study we investigated the role of KMT2C (a chromatin-modifying and remodelling protein) in osteosarcoma progression through cell migration and invasion assays in osteosarcoma primary and metastatic cell lines. Wound healing and transwell assays were used to detect changes of cell migration and matrigel assay was used to evaluate changes of cell invasion in primary and metastatic osteosarcoma cell lines after KMT2C siRNA transfection. We found that primary osteosarcoma cell lines showed the highest capacity of migration before mRNA KMT2C silencing and the highest capacity of invasion after mRNA KMT2C silencing; on the contrary, osteosarcoma metastatic cell line showed the highest capacity of migration after mRNA KMT2C silencing and the highest capacity of invasion before mRNA KMT2C silencing. Our study supports data in favour of selective enhancer changes, KMT2C-mediated, in metastatic osteosarcoma probably due to the different microenvironment between primary and metastatic sites

Pseudo Goldstones at Future Colliders from the Extended Bess Model

We consider the production of the lightest pseudo-Goldstone bosons at future colliders through the vector resonances predicted by the extended BESS model, which consists of an effective lagrangian parametrization with dynamical symmetry breaking, describing scalar, vector and axial-vector bound states in a rather general framework. We find that the detection of pseudo-Goldstone pairs at LHC requires a careful evaluation of backgrounds. For e+e- collisions in the TeV range the backgrounds can be easily reduced and the detection of pseudo-Goldstone pairs is generally easier.Comment: 17 pages and 12 figures (included as a uuencoded tar file), LaTeX (style article), UGVA-DPT 1994/03-84

An NLO calculation of the electroproduction of large-E_\bot hadrons

We present a Next-to-Leading Order calculation of the cross section for the leptoproduction of large-$E_{\bot}$ hadrons and we compare our predictions with H1 data on the forward production of $\pi^0$. We find large higher order corrections and an important sensitivity to the renormalization and factorization scales. These large corrections are shown to arise in part from BFKL-like diagrams at the lowest order.Comment: 24 pages, plain LaTeX2e, 10 figure