Genotyping and allele frequency of <i>AURKA</i> single nucleotide polymorphism in oral cancer and normal controls.

<p>Genotyping and allele frequency of <i>AURKA</i> single nucleotide polymorphism in oral cancer and normal controls.</p

Frequencies of <i>AURKA</i> haplotypes in OSCC patients and control subjects.

<p>Frequencies of <i>AURKA</i> haplotypes in OSCC patients and control subjects.</p

Effects of STE on the MAPKs pathway and Akt signalings.

<p>Effects of STE on the MAPKs pathway and Akt signalings.</p

Effects of STE on the activity and protein level of MMP-2, MMP-9 and the protein level of the endogenous inhibitor TIMP-2 and TIMP-1.

<p>(A and B) HSC-3 cells were treated with STE (0-100 µg/mL) for 24 h and then subjected to gelatin zymography to analyze the activity of MMP-2 and MMP-9, respectively. (C) HSC-3 cells were treated with STE (0-100 µg/mL) for 24 h and then subjected to western blotting to analyze the protein levels of MMP-2, MMP-9, TIMP-1 and TIMP-2. (D) Quantitative results of MMP-2, MMP-9, TIMP-1 and TIMP-2 protein levels which were adjusted with β-actin protein level. The values represented the means ± SD of at least three independent experiments. *p < 0.05 as compared with the vehicle group.</p

Combined effect of betel quid chewing and <i>AURKA</i> haplotypes on OSCC development.

<p>Combined effect of betel quid chewing and <i>AURKA</i> haplotypes on OSCC development.</p

Effect of STE on cell migration and invasion in HSC-3 cells.

<p>(A) The cell migration and (B) cell invasion were measured using a Boyden chamber for 16h and 24 h with polycarbonate filters respectively. The migration and invasion abilities of HSC-3 cells were quantified by counting the number of cells that invaded to the underside of the porous polycarbonate as described in the <i>Materials and Methods</i> section. The values represented the means ± SD of at least three independent experiments. *p < 0.05 as compared with the vehicle group.</p

The distributions of demographical characteristics in 1200 controls and 876 male patients with oral cancer.

<p>The distributions of demographical characteristics in 1200 controls and 876 male patients with oral cancer.</p

Critical role of transcription factor in STE-induced transcriptional inhibition of MMP-2 and MMP-9 in HSC-3 cells.

<p>Critical role of transcription factor in STE-induced transcriptional inhibition of MMP-2 and MMP-9 in HSC-3 cells.</p

STE suppresses MMP-2 and MMP-9 expression at a transcriptional level.

<p>STE suppresses MMP-2 and MMP-9 expression at a transcriptional level.</p

Effect of <i>AURKA</i> rs2064863 polymorphism on clinical statuses in 786 male oral cancer.

<p>Effect of <i>AURKA</i> rs2064863 polymorphism on clinical statuses in 786 male oral cancer.</p